Results 51 to 60 of about 1,124 (207)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Fluoride detoxification in tea plants depends on aluminum and localization in the epidermis
Plant PhysiologyAbstract Tea (Camellia sinensis) is a hyperaccumulator of both aluminum (Al) and fluorine (F). While the formation of Al-F complexes has been proposed as a key mechanism for F detoxification and accumulation in tea, excessive Al and especially fluoride (F−) pose health risks to humans. In this study, we tested the hypothesis that Al3+
Chenyu Zhang +10 more
openaire +4 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Why plants make puzzle cells, and how their shape emerges
eLife, 2018 The shape and function of plant cells are often highly interdependent. The puzzle-shaped cells that appear in the epidermis of many plants are a striking example of a complex cell shape, however their functional benefit has remained elusive.
Aleksandra Sapala +14 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Analysis of Calcium Spiking in Plant Root Epidermis through CWC Modeling
Electronic Notes in Theoretical Computer Science, 2011 AbstractThe purpose of this study is to explore the possibility to mimic, in silico, biological experiments. From the formulation of a biological model using a formal calculus, the corresponding stochastic simulations are statistically compared with measured experimental data in terms of its qualitative behavior.
Eva Sciacca +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Вавиловский журнал генетики и селекции, 2018 The leaf epidermis of a monocotyledonous plant is a widely used model system for studying the differentiation of plant cells, as it contains readily observable specialized cells.
U. S. Zubairova, A. V. Doroshkov
doaj +1 more source