Results 61 to 70 of about 458,576 (332)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Anti-quorum Sensing and Antimicrobial Effect of Mediterranean Plant Essential Oils Against Phytopathogenic Bacteria

Frontiers in Microbiology, 2019
Essential oils (EOs) are one of the most interesting natural products extracted from different aromatic plants. For centuries, EOs have been considered an essential part of the traditional pharmacopeia.
I. Camele, H. S. Elshafie, L. Caputo, V. De Feo   +3 more
semanticscholar   +1 more source

Influence of extraction methods on the composition of essential oils of Achillea millefolium L. from Lithuania [PDF]

, 2014
In this study, flowering aerial parts of Achillea millefolium were used as a matrix for supercritical CO2 extraction (SFE) of volatile oil. The collected extracts were analyzed by GC-FID and GC-MS methods and their composition were compared with that of ...
Bagdonaite, E., Falconieri, D, Marzouki, H, PIRAS, ALESSANDRA, PORCEDDA, SILVIA   +4 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Chemical Composition of Essential Oils and Local Knowledge of Myrica gale in Lithuania

Plants, 2023
Myrica gale L. (Myricaceae) is an essential oil-bearing plant that is rare in Lithuania and naturally grows only in the western part of the country.
Kristina Ložienė, Viktorija Maskolaitytė, Juozas Labokas, Jurga Būdienė, Vaida Vaičiulytė   +4 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Antiviral Activity of Selected Lamiaceae Essential Oils and Their Monoterpenes Against SARS-Cov-2

Frontiers in Pharmacology, 2022
This study presents the very first report on the in vitro antiviral activity of selected essential oils of Lamiaceae plant species and their monoterpenes against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Sanja Ćavar Zeljković, Sanja Ćavar Zeljković, Ermin Schadich, Petr Džubák, Petr Džubák, Marián Hajdúch, Marián Hajdúch, Petr Tarkowski, Petr Tarkowski   +8 more
doaj   +1 more source

Subcritical water extraction of essential oils and plant oils

Sustainable Chemistry and Pharmacy, 2023
Subcritical water extraction is a green technology with interesting advantages in relation to the possibility of processing fresh raw materials to sustainably obtain natural valuable products. The potential of this technology for the aqueous extraction of lipophilic fractions from plant biomass is well known and has recently attracted renewed interest.
Beatriz Díaz-Reinoso, Sandra Rivas, Jorge Rivas, Herminia Domínguez   +3 more
openaire   +2 more sources

Primjena eteričnih ulja za masažu [PDF]

, 2016
Many plant species have been used for the massage mainly in the form of essential oils. The most common oils are obtained from the following plant species: Lavandula angustifolia, Rosmarinus officinalis, Mentha x piperita, Melaleuca alternifolia ...
Bach-Rojecky, Lidija, Maleš, Željan, Mišković, Gjuro, Žunić, Katarina   +3 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source