Results 231 to 240 of about 2,543,561 (297)

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

open access: yesAdvanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao   +7 more
wiley   +1 more source

Modulatory Effects of Antioxidant Supplementation on Serum Oxidative Stress Biomarkers MDA and T-AOC in Females with Unexplained Infertility. [PDF]

open access: yesAntioxidants (Basel)
Didžiokaitė G   +5 more
europepmc   +1 more source

Plants Used in the Traditional Treatment of Infertility in Türkiye: A Systematic Review of Ethnopharmacological Evidence

open access: yesİstanbul Journal of Pharmacy
Serap Rifai   +4 more
openaire   +1 more source

Biofilm‐Binding Phages Enhance Biofilm Eradication by Synergistic Photothermal and Photodynamic Therapy

open access: yesAdvanced Science, EarlyView.
Engineered phage‐based trifunctional nanofibers are developed for synergistic biofilm eradication. Biofilm‐binding phages, armed with AuNPs and TCPP, serve as both warheads and scaffolds, endowing the phototherapy agents with biofilm‐anchoring ability. Upon light irradiation, AuNPs induce photothermal therapy, while TCPP generates 1O2 for photodynamic ...
Ying Cao   +9 more
wiley   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

open access: yesAdvanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj   +25 more
wiley   +1 more source

Stage‐Adaptive Janus Microneedle System for Redox‐Immune Regulation and Mitochondrial Protection in Infected Diabetic Wound Healing

open access: yesAdvanced Science, EarlyView.
ABSTRACT Infected diabetic wounds are sustained by a vicious cycle of hyperglycemia‐driven bacterial infection, persistent oxidative stress, and excessive inflammation, which collectively disrupt the ordered progression of tissue repair. Here, we engineered a stage‐adaptive Janus microneedle patch (MN‐FeSAC‐PPE) to enable a staged therapeutic process ...
Mengting Yin   +13 more
wiley   +1 more source

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