Results 171 to 180 of about 195,044 (308)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Opposing regulation of L-theanine biosynthesis by CsWRKY65 and CsWRKY69 in tea plant roots. [PDF]

Hortic Res
Liu P, Zhang Y, Bao Y, Chen D, Xiao Y, Deng H, Ge Z, Wang P, Yu Y.   +8 more
europepmc   +1 more source

Semantic segmentation of plant roots from RGB (mini-) rhizotron images-generalisation potential and false positives of established methods and advanced deep-learning models. [PDF]

Plant Methods, 2023
Baykalov P, Bussmann B, Nair R, Smith AG, Bodner G, Hadar O, Lazarovitch N, Rewald B.   +7 more
europepmc   +1 more source

Plants protect their roots by alerting the enemies of grubs

, 2001
R.W.H.M. van Tol, A.T.C. van der Sommen, Mari Inês Caríssimi Boff, J. van Bezooijen, Maurice W. Sabelis, P. H. Smits   +5 more
openalex   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Catalog of operational taxonomic units and unified amplicon sequencing data for the microbiomes of medicinal plant roots. [PDF]

Eng Microbiol, 2023
Wang M, Lei M, He H.
europepmc   +1 more source

Plant Cell Responses to Arbuscular Mycorrhizal Fungi: Getting to the Roots of the Symbiosis.

, 1996
V. Gianinazzi-Pearson
openalex   +2 more sources

Plant psychology: At the roots of cognition

, 2020
Umberto Castiello, Silvia Guerra
openalex   +2 more sources

Manipulation of plant innate immunity and gibberellin as factor of compatibility in the mutualistic association of barley roots with Piriformospora indica [PDF]

, 2009
Patrick Schäfer, Stefanie Pfiffi, Lars M. Voll, Doreen Zajic, Peter M. Chandler, Frank Waller, Uwe Scholz, Jörn Pons‐Kühnemann, Sophia Sonnewald, Uwe Sonnewald, Karl‐Heinz Kogel   +10 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source