Results 111 to 120 of about 413,602 (244)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

A Comprehensive Overview on Valuable Tropane Alkaloids: Scopolamine, Atropine, and Hyoscyamine

Journal of Medicinal Plants, 2019
Tropane alkaloids such as scopolamine (C17H21NO4), atropine (C17H23NO3) and hyoscyamine (C17H23NO3) are the most important plant secondary metabolites in the pharmaceutical industry due to anticholinergic activity, competition with muscarinic receptors ...
F Navasi, H Naghdi Badi, A Mehrafarin, Sh Rezazadeh, Sh Mustafavi, M Ghorbanpour   +5 more
doaj  

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Economic Valuation of Medicinal Plants in Peninsular Malaysia [PDF]

, 2004
Medicinal plants are known as important non-timber forest products (NTFPs), besides bamboo and rattan, which have had great demand by rural people and the industries lately. The increasing awareness of herbal remedies and the demand of herbal products
Muhammed Idris, Mohd Azmi
core  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Overview of the antibacterial properties of essential oils and extracts of medicinal plants in Iran [PDF]

, 2016
Background and aims: With increased resistance resulting from overusing of chemical-synthetic antibiotics, finding alternative medicines that have antibacterial properties and they have the least side effects on human health appears to be necessary. Many
Molavi Choobini, Sedigheh., Molavi Choobini, Zahra., Razavi, Nastaran., Saleh Riyahi, Saeideh., Salehian Dehkordi, Mahboubeh., Salehian Dehkordi, Mahsa.   +5 more
core  

Cytotoxicity and Antioxidant Activity of Five Plant Species of Solanaceae Family from Iran

Journal of Medicinal Plants, 2012
Background: The use of natural products as anticancer and antioxidant agents has a long history. Several drugs currently used in chemotherapy were isolated from plant species.
F Khalighi-Sigaroodi, M Ahvazi, D Yazdani, M Kashefi   +3 more
doaj  

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

A comprehensive review on Allium hirtifolium Boiss as a medicinal and edible plant [PDF]

, 2016
Medicinal plants are native legacies with universal and global significance that are considered as one of the most valuable assets of each country. To gain knowledge of these plants is one of the most important indicators of development in any countries.
Aleebrahim-Dehkordy, Elahe., Ghasemi-Pirbalouti, Abdollah., Mirhoseini, Mahmoud.   +2 more
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