Results 121 to 130 of about 205,606 (312)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Cytotoxicity and Antioxidant Activity of Five Plant Species of Solanaceae Family from Iran
Journal of Medicinal Plants, 2012 Background: The use of natural products as anticancer and antioxidant agents has a long history. Several drugs currently used in chemotherapy were isolated from plant species.
F Khalighi-Sigaroodi +3 more
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Journal of Medicinal Plants, 2017 Background: The application of methanol biostimulant and potassium sulfate with reducing of photorespiration and transpiration in C3 plants, increasing the absorption of water and food, and biosynthesis of amino acids can have a direct or indirect effect
A Mehrafarin +4 more
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Shifting from Agriculture to Agribusiness: The Case of Aromatic Plants
This study has examined the agribusiness opportunities in medicinal and aromatic plants (MAPs), based on the field level information from the state of Uttarakhand. The financial feasibility of important aromatic plants has been studied. It has been found
Mittal, Rashi, Singh, S.P.
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Hydroponic cultivation of medicinal plants
, 2013 Medicinal plants are specifically used for their contents of bioactive compounds, which are products of plant secondary metabolism with proven beneficial effects on human health. These substances are known to play a key role in the mechanisms of plant
PARDOSSI, ALBERTO +2 more
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NEW DEVELOPMENT ON MEDICINAL AND AROMATIC PLANTS
, 2021 The negative consequences of rapid industrialization experienced today pandemicallay, terms of environment and human friendliness, has gained importance. Natural procedures that do not harm nature and people, use natural raw materials and do not leave
Kaynar, Hülya, Tonus, Emine
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Journal of Medicinal Plants, 2020 Background: Many herbal remedies have been used in medical systems for the cure of diseases. One of these important applications is usage of them as cytotoxic agents for the treatment of cancers and tumors.
Narges Pournaghi +3 more
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