Results 1 to 10 of about 503,732 (331)
The role of p53 in atherosclerosis [PDF]
, 2006 Although the role of the tumour suppressor gene p53 is well known in cancer, recent studies have highlighted a fundamental role for p53 in regulating cells in the advanced atherosclerotic plaque, the major cause of heart attacks and stroke. In particular,
Bennett, M., Mercer, J.R.
core +1 more source
Natriuretic peptide receptor-C is up-regulated in the intima of advanced carotid artery atherosclerosis [PDF]
, 2016 OBJECTIVE: Natriuretic peptide receptor-C (NPR-C/NPR-3) is a cell surface protein involved in vascular remodelling that is up-regulated in atherosclerosis. NPR-C expression has not been well characterized in human carotid artery occlusive lesions.
Abendschein, Dana R +7 more
core +3 more sources
PLoS ONE, 2023 Acid sphingomyelinase (ASM) promotes atherogenesis and acute cardiovascular events. We previously demonstrated ASM inhibitor desipramine attenuated oxidized-LDL-induced macrophage apoptosis in vitro.
Min Zhao +6 more
doaj +2 more sources
Quantification of atherosclerotic plaque volume in coronary arteries by computed tomographic angiography in subjects with and without diabetes. [PDF]
, 2020 BackgroundDiabetes mellitus (DM) is considered a cardiovascular risk factor. The aim of this study was to analyze the prevalence and volume of coronary artery plaque in patients with diabetes mellitus (DM) vs. those without DM.MethodsThis study recruited
An, Yun-Qiang +6 more
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Circulation Research, 2018 Rationale: Monocyte infiltration into the subintimal space and its intracellular lipid accumulation are the most prominent features of atherosclerosis.
Kyeongdae Kim +22 more
semanticscholar +1 more source
Vulnerable Plaque, Characteristics, Detection, and Potential Therapies
Journal of Cardiovascular Development and Disease, 2019 Plaque development and rupture are hallmarks of atherosclerotic vascular disease. Despite current therapeutic developments, there is an unmet necessity in the prevention of atherosclerotic vascular disease. It remains a challenge to determine at an early
Anouar Hafiane
doaj +1 more source
Gene deficiency in activating Fcγ receptors influences the macrophage phenotypic balance and reduces atherosclerosis in mice [PDF]
, 2013 Immunity contributes to arterial inflammation during atherosclerosis. Oxidized low-density lipoproteins induce an autoimmune response characterized by specific antibodies and immune complexes in atherosclerotic patients.
Egido, J. +9 more
core +5 more sources
Improved detection of molecular markers of atherosclerotic plaques using sub-millimeter PET imaging [PDF]
, 2020 Since atherosclerotic plaques are small and sparse, their non-invasive detection via PET imaging requires both highly specific radiotracers as well as imaging systems with high sensitivity and resolution.
Bormans, Guy +11 more
core +2 more sources
Scientific Reports, 2023 Extracellular vesicles (EV) are a novel biomarker source for diagnosis and prognosis of cardiovascular disease. A protein comparison of plasma EVs in relation to blood plasma and atherosclerotic plaque has not been performed but would provide insight ...
Maarten C. Verwer +7 more
doaj +1 more source
Myeloid cell-specific Irf5 deficiency stabilizes atherosclerotic plaques in Apoe–/– mice
Molecular Metabolism, 2021 Objective: Interferon regulatory factor (IRF) 5 is a transcription factor known for promoting M1 type macrophage polarization in vitro. Given the central role of inflammatory macrophages in promoting atherosclerotic plaque progression, we hypothesize ...
Julia Leipner +17 more
doaj +1 more source