Results 31 to 40 of about 503,732 (331)

Ginsenoside Rb1 Enhances Plaque Stability and Inhibits Adventitial Vasa Vasorum via the Modulation of miR-33 and PEDF

Frontiers in Cardiovascular Medicine, 2021
Background: Atherosclerosis is closely associated with proliferation of the adventitial vasa vasorum, leading to the atherosclerotic plaque progression and vulnerability.
Xiaoyan Yang, Xiaoyan Yang, Lei Wang, Zihao Zhang, Jiayi Hu, Xiaoling Liu, Hao Wen, Hao Wen, Minghao Liu, Minghao Liu, Xue Zhang, Xue Zhang, Hongyan Dai, Mei Ni, Rui Li, Rong Guo, Lei Zhang, Xiaorong Luan, Huili Lin, Mei Dong, Huixia Lu   +20 more
doaj   +1 more source

Association Between Immune Checkpoint Inhibitors With Cardiovascular Events and Atherosclerotic Plaque

Circulation, 2020
Supplemental Digital Content is available in the text. Background: Immune checkpoint inhibitors (ICIs) treat an expanding range of cancers. Consistent basic data suggest that these same checkpoints are critical negative regulators of atherosclerosis ...
Z. Drobni, R. Alvi, J. Taron, A. Zafar, Sean P. Murphy, Paula K. Rambarat, Rayma C. Mosarla, Charlotte E. Lee, Daniel A. Zlotoff, V. Raghu, Sarah E. Hartmann, H. Gilman, J. Gong, L. Zubiri, R. Sullivan, K. Reynolds, T. Mayrhofer, Lili Zhang, U. Hoffmann, T. Neilan   +19 more
semanticscholar   +1 more source

Stabilization of atherosclerotic plaques: an update [PDF]

European Heart Journal, 2013
The majority of coronary thrombi (∼75%) is caused by plaque rupture .1,2 Prototype of the rupture-prone plaque contains a large, soft, lipid-rich necrotic core with a thin and inflamed fibrous cap, so-called thin-cap fibroatheroma (TCFA) ( Figure 1 ).3,4 Other common features include expansive remodelling, large plaque size, plaque haemorrhage ...
Yla-Herttuala, S., Bentzon, J.F., Daemen, M., Falk, E., Garcia-Garcia, H.M., Herrmann, J., Hoefer, I., Jauhiainen, S., Jukema, J.W., Krams, R., Kwak, B.R., Marx, N., Naruszewicz, M., Newby, A., Pasterkamp, G., Serruys, P.W.J.C., Waltenberger, J., Weber, C., Tokgozoglu, L., ESC Working Grp Atherosclerosis Va   +19 more
openaire   +8 more sources

MicroRNAs in the Atherosclerotic Plaque [PDF]

Clinical Chemistry, 2013
BACKGROUND MicroRNAs (miRNA, miR) are noncoding RNAs that regulate gene expression by hindering translation. miRNA expression profiles have been shown to differ in vivo and in vitro in many cellular processes associated with cardiovascular diseases (CVDs).
Emma Raitoharju, Niku Oksala, Terho Lehtimäki   +2 more
openaire   +2 more sources

Atherosclerotic carotid plaque segmentation [PDF]

The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2005
Atherosclerosis is the major cause of heart attack and stroke in the western world. In this paper we present a computerized method for segmenting the athrerosclerotic carotid plaque from ultrasound images. The method uses the blood flow image first to detect the initial contour of the plaque, and then despeckle filtering and snakes to deform the ...
Loizou, C.P., Pattichis, C.S., Istepanian, R.S.H., Pantziaris, M., Nicolaides, A.N.   +4 more
openaire   +4 more sources

Regulation of atherosclerotic plaque inflammation [PDF]

Journal of Internal Medicine, 2015
AbstractThe immune reactions that regulate atherosclerotic plaque inflammation involve chemokines, lipid mediators and costimulatory molecules. Chemokines are a family of chemotactic cytokines that mediate immune cell recruitment and control cell homeostasis and activation of different immune cell types and subsets.
M. Bäck, M. Bäck, C. Weber, C. Weber, E. Lutgens, E. Lutgens   +5 more
semanticscholar   +4 more sources

Effects of norepinephrine on plaque hypoxia in atherosclerotic rabbits

Frontiers in Cardiovascular Medicine, 2023
BackgroundHypoxia plays a vital role throughout the whole process of atherosclerotic vulnerable plaque formation, which may be induced by a reduced oxygen supply.
Jia-Yu Wang, Kun Liu, Yu-Bo Wang, You-Bin Deng, Jie Sun   +4 more
doaj   +1 more source

Matrix Metalloproteinases as Biomarkers of Atherosclerotic Plaque Instability

International Journal of Molecular Sciences, 2020
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases responsible for tissue remodeling and degradation of extracellular matrix (ECM) proteins.
W. Olejarz, Dominika Łacheta, Grażyna Kubiak-Tomaszewska   +2 more
semanticscholar   +1 more source

siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

Science Translational Medicine, 2020
Targeted siRNA nanoparticles can specifically inhibit pro-atherogenic macrophage pathways to combat atherosclerotic vascular disease. Perturbing plaque macrophages Macrophages in atherosclerotic lesions promote inflammation and plaque progression and are
Wei Tao, Arif Yurdagul, Na Kong, Wenliang Li, Xiaobo Wang, Amanda C. Doran, Chan Feng, Junqing Wang, M. Islam, O. Farokhzad, I. Tabas, Jinjun Shi   +11 more
semanticscholar   +1 more source

Calcification in Atherosclerotic Plaque Vulnerability: Friend or Foe?

Frontiers in Physiology, 2020
Calcification is a clinical marker of atherosclerosis. This review focuses on recent findings on the association between calcification and plaque vulnerability.
Xuan-YAN Shi, Jie Gao, Qiushi Lv, Haodi Cai, F. Wang, Ruidong Ye, Xinfeng Liu   +6 more
semanticscholar   +1 more source