Results 31 to 40 of about 143,458 (285)

High-Resolution MRI of Intracranial Atherosclerotic Disease [PDF]

Neurointervention, 2014
Intracranial atherosclerotic disease (ICAD) causes up to 10% of all ischemic strokes, and the rate of recurrent vascular ischemic events is very high. Important predictors of vulnerability in atherosclerotic plaques include the degree of stenosis and the
Chang-Woo Ryu, Hyo-Sung Kwak, Geon-Ho Jahng, Han Na Lee   +3 more
doaj   +1 more source

Genetic susceptibility loci for cardiovascular disease and their impact on atherosclerotic plaques [PDF]

, 2018
Background: Atherosclerosis is a chronic inflammatory disease in part caused by lipid uptake in the vascular wall, but the exact underlying mechanisms leading to acute myocardial infarction and stroke remain poorly understood. Large consortia identified
Asselbergs, Folkert W, Björkegrenn, Johan L.M, de Bakker, Paul I.W, de Borst, Gert J., den Ruijter, Folkert W, Dichgans, Martin, Erdmann, Jeanette, Ford, Ian, Foroughi Asl, Hassan, Haitjema, Saskia, Hedin, Ulf, Malik, Rainer, Mokry, Michal, Pasterkamp, Gerard, Paulsson-Berne, Gabrielle, Perisic, Ljubica, Samani, Nilesh J, Sattar, Naveed, Schunkert, Heribert, Siemelink, Marten A., Stott, David J., van der Laan, Sander W., van Setten, Jessica, Worrall, Bradford B   +23 more
core   +2 more sources

Machine Learning Framework to Identify Individuals at Risk of Rapid Progression of Coronary Atherosclerosis: From the PARADIGM Registry. [PDF]

, 2020
Background Rapid coronary plaque progression (RPP) is associated with incident cardiovascular events. To date, no method exists for the identification of individuals at risk of RPP at a single point in time.
Al'Aref, Subhi J, Andreini, Daniele, Baskaran, Lohendran, Bax, Jeroen J, Berman, Daniel S, Budoff, Matthew J, Cademartiri, Filippo, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Choi, Jung Hyun, Chun, Eun Ju, Conte, Edoardo, de Araújo Gonçalves, Pedro, Gottlieb, Ilan, Gransar, Heidi, Hadamitzky, Martin, Han, Donghee, Kim, Yong-Jin, Kolli, Kranthi K, Lee, Byoung Kwon, Lee, Sang-Eun, Leipsic, Jonathon A, Lin, Fay Y, Maffei, Erica, Marques, Hugo, Min, James K, Narula, Jagat, Pontone, Gianluca, Raff, Gilbert L, Samady, Habib, Shaw, Leslee J, Shin, Sangshoon, Stone, Peter, Sung, Ji Min, van Rosendael, Alexander R, Virmani, Renu   +35 more
core  

Orthopedic surgery increases atherosclerotic lesions and necrotic core area in ApoE-/- mice [PDF]

, 2016
Background and aims Observational studies show a peak incidence of cardiovascular events after major surgery. For example, the risk of myocardial infarction increases 25-fold early after hip replacement.
Chen, Cohen, Corrales-Medina, Dutta, Dutta, Gualandro, Hans W.M. Niessen, Hanson, Ilse P.A. Zethof, Janssen, Kaynar, King, Kleemann, Lalmohamed, Landesberg, Lars F.H. Theyse, Libby, Martine C. Morrison, Moore, Morrison, Naghavi, Paul A.J. Krijnen, Reid, Rianne van der Linden, Robert Kleemann, Santos-Gallego, Santos-Gallego, Santos-Gallego, Seimon, Smeeth, Tan, Thompson, Thompson, Van der Donckt, van Dijk, Virmani, Virmani, Wessel W. Fuijkschot, Yvo M. Smulders, Zhang   +39 more
core   +2 more sources

Effect of calcification on the mechanical stability of plaque based on a three-dimensional carotid bifurcation model

BMC Cardiovascular Disorders, 2012
Background This study characterizes the distribution and components of plaque structure by presenting a three-dimensional blood-vessel modelling with the aim of determining mechanical properties due to the effect of lipid core and calcification within a ...
Wong Kelvin KL, Thavornpattanapong Pongpat, Cheung Sherman CP, Sun Zhonghua, Tu Jiyuan   +4 more
doaj   +1 more source

Desipramine enhances the stability of atherosclerotic plaque in rabbits monitored with molecular imaging.

PLoS ONE, 2023
Acid sphingomyelinase (ASM) promotes atherogenesis and acute cardiovascular events. We previously demonstrated ASM inhibitor desipramine attenuated oxidized-LDL-induced macrophage apoptosis in vitro.
Min Zhao, Baiyang You, Xiaole Wang, Jin Huang, Ming Zhou, Ruizheng Shi, Guogang Zhang   +6 more
doaj   +2 more sources

Natriuretic peptide receptor-C is up-regulated in the intima of advanced carotid artery atherosclerosis [PDF]

, 2016
OBJECTIVE: Natriuretic peptide receptor-C (NPR-C/NPR-3) is a cell surface protein involved in vascular remodelling that is up-regulated in atherosclerosis. NPR-C expression has not been well characterized in human carotid artery occlusive lesions.
Abendschein, Dana R, Detering, Lisa, Harring, Scott D, Liu, Yongjian, Lu, Dongsi, Vemuri, Chandu, Woodard, Pamela K, Zayed, Mohamed A   +7 more
core   +3 more sources

Quantification of atherosclerotic plaque volume in coronary arteries by computed tomographic angiography in subjects with and without diabetes. [PDF]

, 2020
BackgroundDiabetes mellitus (DM) is considered a cardiovascular risk factor. The aim of this study was to analyze the prevalence and volume of coronary artery plaque in patients with diabetes mellitus (DM) vs. those without DM.MethodsThis study recruited
An, Yun-Qiang, Budoff, Matthew J, Gao, Yang, Hou, Zhi-Hui, Li, Zhen-Nan, Lu, Bin, Yin, Wei-Hua   +6 more
core   +1 more source

Vulnerable Plaque, Characteristics, Detection, and Potential Therapies

Journal of Cardiovascular Development and Disease, 2019
Plaque development and rupture are hallmarks of atherosclerotic vascular disease. Despite current therapeutic developments, there is an unmet necessity in the prevention of atherosclerotic vascular disease. It remains a challenge to determine at an early
Anouar Hafiane
doaj   +1 more source

Comparison of cardiovascular biomarker expression in extracellular vesicles, plasma and carotid plaque for the prediction of MACE in CEA patients

Scientific Reports, 2023
Extracellular vesicles (EV) are a novel biomarker source for diagnosis and prognosis of cardiovascular disease. A protein comparison of plasma EVs in relation to blood plasma and atherosclerotic plaque has not been performed but would provide insight ...
Maarten C. Verwer, Joost Mekke, Nathalie Timmerman, Farahnaz Waissi, Arjan Boltjes, Gerard Pasterkamp, Gert J. de Borst, Dominique P. V. de Kleijn   +7 more
doaj   +1 more source