Results 91 to 100 of about 383,796 (264)

Anti‐CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti‐diacylglycerol lipase alpha (DAGLA) antibody‐mediated autoimmune encephalitis, achieving partial clinical remission.
Dimitrios Mougiakakos, Marwa Al‐Dubai, Denise Walther, Dominic Borie, Jan D. Lünemann, Marc Pawlitzki, Sven G. Meuth, Solveig Henneicke, Stefan Vielhaber, Stefanie Schreiber   +9 more
wiley   +1 more source

Metabolic changes and plasma glycine predict the risk of acute cellular rejection in heart transplantationCentral MessagePerspective

JTCVS Open
Objective: Brain death in organ donors may trigger tissue injury that can negatively influence transplant outcome. We analyzed plasma metabolomic profiles in heart transplant donors and tested whether any donor metabolite may predict the risk of acute ...
Kishor Dhaygude, MSc, PhD, Richard S. Krebs, MB, Rainer Krebs, MSc, PhD, SeoJeong Joo, MSc, Maria Hurskainen, MD, PhD, Emil J. Holmström, MD, PhD, Simo O. Syrjälä, MD, PhD, Sangita Kulathinal, MSc, PhD, Antti I. Nykänen, MD, PhD, Karl B. Lemström, MD, PhD   +9 more
doaj   +1 more source

Alzheimer's disease plasma biomarkers in the Midwestern Amish

Alzheimer's & Dementia
AbstractINTRODUCTIONAlzheimer's disease (AD) plasma biomarkers are non‐invasive measures of the key amyloid beta (Aβ) and tau pathologies. Validation and generalization studies are needed to fully understand their potential for AD prediction and diagnosis in the elderly population.METHODSIn 1067 Amish individuals aged ≥ 65, we measured plasma Aβ and ...
Ping Wang, Yeunjoo E. Song, Audrey Lynn, Kristy Miskimen, Alex Gulyayev, Michael B. Prough, Daniel A. Dorfsman, Renee A. Laux, Sarada L. Fuzzell, Sherri D. Hochstetler, Andrew F. Zaman, Larry D. Adams, Laura J. Caywood, Jason E. Clouse, Sharlene D. Herington, Patrice Whitehead, Yining Liu, Noel Moore, Paula Ogrocki, Alan J. Lerner, Anthony J. Griswold, Jeffery M. Vance, Michael L. Cuccaro, William K. Scott, Margaret A. Pericak-Vance, Jonathan L. Haines   +25 more
openaire   +3 more sources

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Racial and ethnic differences in plasma p‐tau217 ratio biomarker eligibility rates in a preclinical AD trial with lecanemab

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Consistent predictive performance across racial and ethnic groups is essential to the use of plasma biomarkers as screening tools in preclinical Alzheimer's disease trials.
Doris P. Molina‐Henry, Rema Raman, Andy Liu, Oliver Langford, Joel B. Braunstein, Philip B. Verghese, Venky Venkatesh, Shobha Dhadda, Michael Irrizary, Joshua D. Grill, Keith Johnson, Robert A. Rissman, Paul Aisen, Reisa A. Sperling, AHEAD 3‐45 Study Team   +14 more
doaj   +1 more source

Plasma cytokine profiles in breast cancer patients and their association with therapeutic response in Peru: a prospective cohort study

Frontiers in Immunology
BackgroundBreast cancer (BC) is the most common malignant neoplasm in women worldwide and in Peru. Beyond hormonal and genetic factors, cytokines play a key role in tumor aggressiveness and therapeutic resistance.
Jose M. Vela-Ruiz, Jose M. Vela-Ruiz, Zaida Morante, Zaida Morante, Yomali Ferreyra, Marco A. Galvez-Villanueva, Fernando Valencia, Fernando Valencia, J. Jhanina Campos-Tineo, Mariana Callapiña De Paz, Ariana Alessandra Córdova-Salazar, Pool Marcos-Carbajal, Pool Marcos-Carbajal, Joan M. Moreno Lujan, Andy R. Pantoja Lazaro, Laura G. Escobar Caipo, Gustavo A. Flores Trujillo, Teresa N. Cusma Quintana, Jhony A. De La Cruz-Vargas, Jhony A. De La Cruz-Vargas, Henry L. Gomez, Henry L. Gomez, Henry L. Gomez, Alonso Soto   +23 more
doaj   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Interchangeability of blood‐based biomarkers and PET to identify Alzheimer's disease pathology

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Establishing interchangeability between blood biomarkers and amyloid‐positron emission tomography (PET) could help identify patients who would benefit from novel amyloid‐targeting therapies for Alzheimer's disease. METHODS Adult participants
Jian Wang, Joel B. Braunstein, Robin Wolz, Laura Harper, Tricia Locascio, Holly E. McPherson, Richard Mohs, Michael J. Pontecorvo, Samantha C. Burnham   +8 more
doaj   +1 more source

Temporal and Severity-Dependent Alterations in Plasma Extracellular Vesicle Profiles Following Spinal Cord Injury

Cells
Spinal cord injury (SCI) triggers both local and systemic pathological responses that evolve over time and differ with injury severity. Small extracellular vesicles (sEVs), known mediators of intercellular communication, may serve as biomarkers ...
Jamie Cooper, Scott Tait Airey, Eric Patino, Theo Andriot, Mousumi Ghosh, Damien D. Pearse   +5 more
doaj   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source