Results 101 to 110 of about 14,295 (215)

Accurate and robust prediction of Amyloid-β brain deposition from plasma biomarkers and clinical information using machine learning

Frontiers in Aging Neuroscience
BackgroundAlzheimer's disease (AD) greatly affects the daily functioning and life quality of patients and is prevalent in the elderly population. Amyloid-β (Aβ) accumulation in the brain is the main hallmark of AD pathophysiology.
Jiayuan Xu, Andrew J. Doig, Sofia Michopoulou, Sofia Michopoulou, Petroula Proitsi, Petroula Proitsi, Fumie Costen, The Alzheimer's disease neuroimaging initiative   +7 more
doaj   +1 more source

Associations Between Biomarkers of Alzheimer's Disease and Sleep in Cognitively Unimpaired Older Adults

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Sleep disturbances have been implicated as a risk factor for developing Alzheimer's disease (AD), but evidence linking plasma AD biomarkers to sleep in cognitively unimpaired individuals remains limited. The present study examined associations between evening, morning, and overnight changes in plasma AD biomarkers and measures of ...
Cornelia Sauter, Hans Dorn, Julian Hellmann‐Regen, Ana Bueno‐Lopez, Verena van Ginneken, Heidi Danker‐Hopfe   +5 more
wiley   +1 more source

P‐tau217 testing impact on intended management of patients presenting with cognitive impairment: A randomized clinical utility study

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Plasma biomarkers are minimally invasive tool for identifying Alzheimer's disease pathology. However, evaluation of their clinical utility remains limited. METHODS This ongoing, open‐label, randomized, two‐arm, multicenter, U.S., prospective,
Samantha C. Burnham, Haoyan Hu, Yifeng Tang, Anthony Sireci, Michael J. Pontecorvo, Paul E. Schulz, Rosemary D. Laird, Curtis P. Schreiber, Rose C. Beck   +8 more
doaj   +1 more source

Diagnostic performance of plasma p-Tau217, p-Tau181, and p-Tau231 across the Alzheimer’s disease continuum: a network meta-analysis

Frontiers in Aging Neuroscience
ImportanceBlood-based biomarkers (BBMs) are transforming the diagnostic workflow for Alzheimer’s disease (AD). However, there is no consensus on the optimal phosphorylated tau (p-tau) isoform (217, 181, or 231) or analytical platform [mass spectrometry ...
Xiaofen Chen, Tingting Huang, Chao Shi, Shuizhi Xu, Shuwei Fan   +4 more
doaj   +1 more source

Improving the Diagnostic Accuracy of Plasma Alzheimer's Disease Biomarkers With Objective and Subjective Cognitive Screening

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Blood‐based biomarkers are increasingly used to identify Alzheimer's disease (AD) pathology and may play an important role in early disease screening and participant selection for clinical trials. However, their performance across stages of cognitive impairment remains unclear. This study examined whether plasma biomarkers differ in
Maryam Abdolmaleki, Leslie S. Gaynor, Dandan Liu, Timothy J. Hohman, Katherine A. Gifford, Henrik Zetterberg, Angela L. Jefferson, Corey J. Bolton   +7 more
wiley   +1 more source

Type 1 diabetes is associated with higher plasma levels of biomarkers of neurodegeneration and neuroinflammation

Frontiers in Immunology
IntroductionType 1 diabetes (T1D) is associated with increased risk of dementias and other neurodegenerative diseases. Plasma biomarkers of neurodegeneration and neuroinflammation hold utility in risk prediction and diagnosis of neurodegenerative disease
Meghan E. Pauley, Christina Coughlan, Christina Coughlan, Fran Dong, Brian Bucca, Bailey Tanner, Catherine Chartier-Logan, Allison L. B. Shapiro, Allison L. B. Shapiro, Janet K. Snell-Bergeon   +9 more
doaj   +1 more source

Acute Endocrine Alterations After Traumatic Brain Injury and 6‐Month Functional Outcome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Acute multi‐axis endocrine alterations after traumatic brain injury (TBI) remain incompletely characterized. This study aimed to examine their temporal patterns and explore their associations with 6‐month functional outcome and early inflammatory markers.
Biao Xu, Peng Guo, Rui Pan, Zhenghao Wang, Jingchao Zhou, Pengcheng Zhang, Xingzhe Zhang, Qinghua Zhang, Haibin Ma, Zhanfeng Niu   +9 more
wiley   +1 more source

Serostatus‐Specific Prognostic Profiles and Phenotype‐Dependent Therapeutic Windows in Autoimmune Encephalitis: A Multicenter Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background While autoimmune encephalitis (AE) outcomes vary, serostatus‐specific prognostic determinants and institutional clustering effects remain poorly characterized. We aimed to delineate the distinct prognostic architecture of AE, identifying serostatus‐specific risk factors and potential therapeutic windows.
Xiaohong Tang, Jingxian Wang, Kaixin Zhu, Zhen Zhang, Liao Wu, Wei Wang, Chang Li, Qingyun Li, Hao Li, Jinghua Chen, Zhangxu Lian, Bin Liu, Tengfei Liu, Chunmei Wen, Nuan Wang, Sen Qun, Lishun Xiao, Qingwei Lai   +17 more
wiley   +1 more source

High-Dimensional Immunophenotyping of Plasma-Derived Small Extracellular Vesicles in Pancreatic Cancer: An Exploratory Proof-of-Principle Study

Biomolecules
Pancreatic ductal adenocarcinoma (PDAC) is increasingly recognized as a systemic malignancy, characterized by profound alterations in tumor–host interactions.
Sabrina Sulzer, Johanna Lisa Becker, Laura Domogalla, Volker Ellenrieder, Matthias Schulz, Markus Maulhardt, Alexander Casimir Angleitner, Judith Büntzel   +7 more
doaj   +1 more source

Rheumatoid Arthritis and Coronary Artery Calcium Progression: A Case Cohort Analysis From ELSA‐Brasil

Arthritis Care &Research, EarlyView.
Objective To investigate the association between rheumatoid arthritis (RA) and coronary artery calcium (CAC) prevalence, incidence, and progression over four years in adults without prior cardiovascular disease. Methods A case‐cohort study within the Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil) included 585 participants (86 patients with ...
Patrícia Fonseca Estrada, Marcos Rafael N. Cavalcante, Itamar de Souza Santos, Márcio S. Bittencourt, Vandrize Meneghini, Paulo A. Lotufo, Alessandra C. Goulart, Isabela M. Bensenor   +7 more
wiley   +1 more source