Results 11 to 20 of about 3,475,545 (379)

Biomarkers of Alzheimer disease in plasma [PDF]

NeuroRX, 2004
Plasma and serum biochemical markers proposed for Alzheimer disease (AD) are based on pathophysiologic processes such as amyloid plaque formation [amyloid beta-protein (A beta), A beta autoantibodies, platelet amyloid precursor protein (APP) isoforms], inflammation (cytokines), oxidative stress (vitamin E, isoprostanes), lipid metabolism ...
Michael C. Irizarry
  +7 more sources

Proteome-based plasma biomarkers for Alzheimer's disease [PDF]

Brain, 2006
Alzheimer's disease is a common and devastating disease for which there is no readily available biomarker to aid diagnosis or to monitor disease progression. Biomarkers have been sought in CSF but no previous study has used two-dimensional gel electrophoresis coupled with mass spectrometry to seek biomarkers in peripheral tissue.
Abdul Hye, Steven Lynham, Madhav Thambisetty, Mirsada Čaušević, James Campbell, Helen L. Byers, Claudie Hooper, Frühling Rijsdijk, Sarah J. Tabrizi, Steven J. Banner, Christopher E. Shaw, C. Foy, Michaela Poppe, Nicola Archer, Gillian Hamilton, John Powell, Richard G. Brown, Pak Sham, Malcolm Ward, Simon Lovestone   +19 more
openalex   +6 more sources

Plasma circRNAs as Biomarkers in Cancer

Cancer Management and Research, 2021
The incidence and mortality of cancer are increasing each year. At present, the sensitivity and specificity of the blood biomarkers that were used in clinical practice are low, which make the detection rate of cancer decrease. With advances in bioinformatics and technology, some non-coding RNA as biomarkers can be easily detected through some ...
Qian Zhou, Lin-Ling Ju, Xiang Ji, Ya-Li Cao, Jian-Guo Shao, Lin Chen   +5 more
openaire   +5 more sources

Plasma miRNAs as biomarkers for endometriosis [PDF]

Human Reproduction, 2019
Abstract STUDY QUESTION Can plasma miRNAs be used for the non-invasive diagnosis of endometriosis in infertile women? SUMMARY ANSWER miRNA-based diagnostic models for endometriosis failed the test of independent validation.
Vanhie, A, O, D, Peterse, D, Beckers, A, Cuéllar, A, Fassbender, A, Meuleman, C, Mestdagh, P, D’Hooghe, T   +8 more
openaire   +5 more sources

High sensitivity and specificity of a 5‐analyte protein and microRNA biosignature for identification of active tuberculosis

Clinical & Translational Immunology, 2021
Objectives Non‐sputum‐based tests to accurately identify active tuberculosis (TB) disease and monitor response to therapy are urgently needed. This study examined the biomarker capacity of a panel of plasma proteins alone, and in conjunction with a ...
Jessica L Pedersen, Simone E Barry, Nilesh J Bokil, Magda Ellis, YuRong Yang, Guangyu Guan, Xiaolin Wang, Alen Faiz, Warwick J Britton, Bernadette M Saunders   +9 more
doaj   +1 more source

Pharmacogenetics-Informed Pharmacometabolomics as an Innovative Approach to Assessing the Safety and Risk of Pharmacotherapy with Valproic Acid

Безопасность и риск фармакотерапии, 2023
Scientific relevance. Valproic acid (VPA) is a psychotropic medicinal product, which may be associated with serious adverse drug reactions (ADRs). While pharmacogenetics and pharmacometabolomics can significantly affect the safety of valproates, there ...
N. A. Shnayder, V. V. Grechkina, V. V. Arkhipov, R. F. Nasyrova   +3 more
doaj   +1 more source

Plasma biomarkers in carbon monoxide poisoning [PDF]

Clinical Toxicology, 2010
The severity of acute carbon monoxide (CO) poisoning is often based on non-specific clinical criteria because there are no reliable laboratory markers. We hypothesized that a pattern of plasma protein values might objectively discern CO poisoning severity.
Stephen R. Thom, Veena M. Bhopale, Tatyana M. Milovanova, Kevin R. Hardy, Christopher Logue, David S. Lambert, Andrea B. Troxel, Kerri Ballard, Dominic Eisinger   +8 more
openalex   +4 more sources

Plasma biomarkers for neurodegenerative disorders: ready for prime time?

Current Opinion in Psychiatry, 2023
Purpose of review Several plasma biomarkers for Alzheimer's disease and related disorders (ADRD) have demonstrated clinical and technical robustness. However, are they ready for clinical implementation?
W. Balogun, H. Zetterberg, K. Blennow, T. Karikari   +3 more
semanticscholar   +1 more source

Inflammatory biomarkers in Alzheimer's disease plasma [PDF]

Alzheimer's & Dementia, 2019
AbstractIntroductionPlasma biomarkers for Alzheimer's disease (AD) diagnosis/stratification are a “Holy Grail” of AD research and intensively sought; however, there are no well‐established plasma markers.MethodsA hypothesis‐led plasma biomarker search was conducted in the context of international multicenter studies.
Morgan, Angharad R., Touchard, Samuel, Leckey, Claire, O'Hagan, Caroline, Nevado-Holgado, Alejo J., Barkhof, Frederik, Bertram, Lars, Blin, Olivier, Bos, Isabelle, Dobricic, Valerija, Engelborghs, Sebastiaan, Frisoni, Giovanni, Froelich, Lutz, Gabel, Silvey, Johannsen, Peter, Kettunen, Petronella, Koszewska, Iwona, Legido-Quigley, Cristina, Lleo, Alberto, Martinez-Lage, Pablo, Mecocci, Patrizia, Meersmans, Karen, Luis Molinuevo, Jose, Peyratout, Gwendoline, Popp, Julius, Richardson, Jill, Sala, Isabel, Scheltens, Philip, Streffer, Johannes, Soininen, Hikka, Tainta-Cuezva, Mikel, Teunissen, Charlotte, Tsolaki, Magda, Vandenberghe, Rik, Visser, Pieter Jelle, Vos, Stephanie, Wahlund, Lars-Olof, Wallin, Anders, Westwood, Sarah, Zetterberg, Henrik, Lovestone, Simon, Morgan, B. Paul, Bullmore, Edward T., Bhatti, Junaid, Chamberlain, Samuel J., Correia, Marta M., Crofts, Anna L., Dickinson, Amber, Foster, Andrew C., Kitzbichler, Manfred G., Knight, Clare, Lynall, Mary-Ellen, Maurice, Christina, O'Donnell, Ciara, Pointon, Linda J., Hyslop, Peter St George, Turner, Lorinda, Vertes, Petra, Widmer, Barry, Williams, Guy B., Morgan, B. Paul, Leckey, ClaireA., Morgan, Angharad R., O'Hagan, Caroline, Touchard, Samuel, Cavanagh, Jonathan, Deith, Catherine, Farmer, Scott, McClean, John, McColl, Alison, McPherson, Andrew, Scouller, Paul, Sutherland, Murray, Boddeke, H.WG.M. Erik, Richardson, Jill C., Khan, Shahid, Murphy, Phil, Parker, Christine A., Patel, Jai, Jones, Declan, de Boer, Peter, Kemp, John, Drevets, Wayne C., Nye, Jeffrey S., Wittenberg, Gayle, Isaac, John, Bhattacharya, Anindya, Carruthers, Nick, Kolb, Hartmuth, Pariante, Carmine M., Turkheimer, Federico, Barker, Gareth J., Byrom, Heidi, Cash, Diana, Cattaneo, Annamaria, Gee, Antony, Hastings, Caitlin, Mariani, Nicole, McLaughlin, Anna, Mondelli, Valeria, Nettis, Maria, Nikkheslat, Naghmeh, Randall, Karen, Sheridan, Hannah, Simmons, Camilla, Singh, Nisha, Van Loo, Victoria, Vicente-Rodriguez, Marta, Wood, Tobias C., Worrell, Courtney, Zajkowska, Zuzanna, Plath, Niels, Egebjerg, Jan, Eriksson, Hans, Gastambide, Francois, Adams, Karen Husted, Jeggo, Ross, Thomsen, Christian, Pederson, Jan Torleif, Campbell, Brian, Moller, Thomas, Nelson, Bob, Zorn, Stevin, O'Connor, Jason, Attenburrow, Mary Jane, Baird, Alison, Benjamin, Jithen, Clare, Stuart, Cowen, Philip, Huang, I-Shu Dante, Hurley, Samuel, Jones, Helen, Lovestone, Simon, Mada, Francisca, Nevado-Holgado, Alejo, Oladejo, Akintayo, Ribe, Elena, Smith, Katy, Vyas, Anviti, Hughes, Zoe, Balice-Gordon, Rita, Duerr, James, Piro, Justin R., Sporn, Jonathan, Perry, V. Hugh, Cleal, Madeleine, Fryatt, Gemma, Gomez-Nicola, Diego, Mancuso, Renzo, Reynolds, Richard, Harrison, Neil A., Cercignani, Mara, Clarke, Charlotte L., Hoskins, Elizabeth, Kohn, Charmaine, Murray, Rosemary, Wilcock, Lauren, Wlazly, Dominika   +157 more
openaire   +8 more sources

Plasma β-amyloid, tau, neurodegeneration biomarkers and inflammatory factors of probable Alzheimer’s disease dementia in Chinese individuals

Frontiers in Aging Neuroscience, 2022
BackgroundPlasma-derived β-amyloid, tau, and neurodegeneration (ATN) biomarkers can accurately diagnose Alzheimer’s disease (AD) and predict its progression.
Qingling Sun, Jingnian Ni, Mingqing Wei, Siwei Long, Ting Li, Dongsheng Fan, Tao Lu, Jing Shi, Jinzhou Tian   +8 more
doaj   +1 more source