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Plasma biomarkers—cost effective, non‐invasive indicators of Alzheimer's disease (AD) and related disorders (ADRD)—have largely been studied in clinical research settings.
P. Ferreira+12 more
semanticscholar +1 more source
Plasma biomarkers of mouse aging [PDF]
Normal aging is accompanied by a series of physiological changes such as gray hair, cataracts, reduced immunity, and increased susceptibility to disease. To identify novel biomarkers of normal aging, we analyzed plasma proteins of male mice longitudinally from 2 to 19 months of age.
Juan Ding, John J. Kopchick
openaire +3 more sources
To examine the burden and clusters of multimorbidity in association with mild cognitive impairment (MCI), dementia, and Alzheimer's disease (AD)‐related plasma biomarkers among older adults.
Yifei Ren+17 more
semanticscholar +1 more source
Proteomics for prediction of disease progression and response to therapy in diabetic kidney disease [PDF]
The past decade has resulted in multiple new findings of potential proteomic biomarkers of diabetic kidney disease (DKD). Many of these biomarkers reflect an important role in the (patho)physiology and biological processes of DKD.
Heerspink, Hiddo J.L.+2 more
core +12 more sources
We investigated whether novel plasma biomarkers are associated with cognition, cognitive decline, and functional independence in activities of daily living across and within neurodegenerative diseases.
Erlan Sanchez+42 more
semanticscholar +1 more source
Revisiting biomarker discovery by plasma proteomics [PDF]
AbstractClinical analysis of blood is the most widespread diagnostic procedure in medicine, and blood biomarkers are used to categorize patients and to support treatment decisions. However, existing biomarkers are far from comprehensive and often lack specificity and new ones are being developed at a very slow rate.
Daniel Teupser+5 more
openaire +6 more sources
The potential clinical value of plasma biomarkers in Alzheimer's disease
Many people with cognitive complaints or impairment never receive an accurate diagnosis of the underlying condition, potentially impacting their access to appropriate treatment.
K. Blennow+9 more
semanticscholar +1 more source
Diagnostic Blood Biomarkers in Alzheimer’s Disease
Potential biomarkers for Alzheimer’s disease (AD) include amyloid β1–42 (Aβ1–42), t-Tau, p-Tau181, neurofilament light chain (NFL), and neuroimaging biomarkers. Their combined use is useful for diagnosing and monitoring the progress of AD.
Jung Eun Park+15 more
doaj +1 more source
Population‐based studies have rarely explored the associations of the triglyceride–glucose (TyG) index, a surrogate marker of insulin resistance, with dementia and plasma biomarkers for amyloid beta (Aβ) and neurodegeneration.
N. Tian+16 more
semanticscholar +1 more source
BackgroundDysregulated immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are thought to underlie the progression of coronavirus disease 2019 (COVID-19) to severe disease.
Rachel MacCann+21 more
doaj +1 more source