Results 101 to 110 of about 315,200 (280)

Adult skeletal muscle stem cell migration is mediated by a blebbing/amoeboid mechanism [PDF]

, 2011
Adult skeletal muscle possesses a resident stem cell population called satellite cells which are responsible for tissue repair following damage. Satellite cell migration is crucial in promoting rapid tissue regeneration but is a poorly understood ...
Collins-Hooper, Henry, Dash, Philip R., Otto, Anthony, Patel, Anand, Patel, Ketan   +4 more
core   +1 more source

Importance of Membrane Curvature Near Hole Edges in Plasma Membrane Repair [PDF]

Biophysical Journal, 2018
Maintaining integrity of the plasma membrane is essential for cell life. Thus, efficient cell membrane repair mechanisms are crucial for handling membrane disruptions resulting from external perturbations of eukaryotic cells. Cancer cells in particular, experience enhanced membrane stress when navigating through the dense extracellular matrix, which ...
Boye, Theresa Louise, Pezeshkian, Weria, Simonsen, Adam Cohen, Nylandsted, Jesper   +3 more
openaire   +2 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Modulation of release kinetics by plasma polymerization of ampicillin-loaded ß-TCP ceramics [PDF]

, 2016
Beta-tricalcium phosphate (ß-TCP) bioceramics are employed in bone repair surgery. Their local implantation in bone defects puts them in the limelight as potential materials for local drug delivery.
Avilés, Marc, Buxadera Palomero, Judit, Canal Barnils, Cristina, Ginebra Molins, Maria Pau, Labay, Cédric Pierre   +4 more
core   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Endomicroscopic and transcriptomic analysis of impaired barrier function and malabsorption in environmental enteropathy [PDF]

, 2016
Introduction: Environmental enteropathy (EE) is associated with growth failure, micronutrient malabsorption and impaired responses to oral vaccines.
A Prendergast, A Veitch, AC Illing, AJ Prendergast, Alastair Watson, AM Marchiando, AM Marchiando, AM Marchiando, AR Tenorio, B Sandström, Beatrice Amadi, D Gunzel, DI Campbell, E Salazar-Lindo, Ellen Besa, EM Vestergaard, G Marchetti, GC Cook, GT Keusch, J Brenchley, J Vesterbacka, J Zulu, James Lees, JH Humphrey, JM Williams, John Louis-Auguste, JR Turner, Kanekwa Zyambo, L Aamann, L Bremholm, LG Lim, LS Valberg, M Kosek, MH Wojcik, MJ Manary, MM Levine, MS Wapenaar, N Kimer, P Bellot, P Janssen, P Kelly, P Kelly, P Kelly, Paul Kelly, PB Jeppesen, Q Xiao, R Kiesslich, R Kiesslich, RL Guerrant, Rose Soko, Rosemary Banda, S Baldassano, S Tarazona, T Mizuno, Themba Banda, U Trautvetter, V Giorgio, VF Zevallos, W Dhaliwal, WA Petri, William A. Petri, Y Guan   +61 more
core   +5 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The development of a ε-polycaprolactone (PCL) scaffold for CNS repair [PDF]

, 2012
Potential treatment strategies for the repair of spinal cord injury (SCI) currently favour a combinatorial approach incorporating several factors, including exogenous cell transplantation and biocompatible scaffolds. The use of scaffolds for bridging the
Gelain F., Lampe K.J., Mathis O. Riehle, Nikolaj Gadegaard, Peter S. Donoghue, Rebecca Lamond, Stephanie D. Boomkamp, Susan C. Barnett, Tao Sun, Thouas G.A.   +9 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source