Results 121 to 130 of about 3,013,542 (232)

Investigating Plasma-Membrane Repair Employing Thermoplasmonics [PDF]

Biophysical Journal, 2021
Moreno Pescador, Guillermo Sergio, Aswad, Dunya S., Arastoo, Mohammadreza, Danielsen, Helena Maria Dávidsdóttir, Florentsen, Christoffer Dam, Bahadori, Azra, Nylandsted, Jesper, Oddershede, Lene Broeng, Bendix, Poul Martin   +8 more
openaire   +2 more sources

Perforin Triggers a Plasma Membrane-Repair Response that Facilitates CTL Induction of Apoptosis

, 2005
SummaryPerforin delivers granzymes to induce target-cell apoptosis. At high concentrations, perforin multimerizes in the plasma membrane to form pores. However, whether granzymes enter target cells via membrane pores is uncertain.
Shi, Lianfa, Massol, Ramiro, Kirchhausen, Tomas, Feske, Stefan, Keefe, Dennis, Navarro, Francisco, Lieberman, Judy   +6 more
core   +1 more source

Evaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).
Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul   +19 more
wiley   +1 more source

Agonal cell resuscitation strategy to promote tissue repair

Nature Communications
Overactive lytic regulated cell death (RCD) causes excessive inflammation and impairs tissue repair. Current strategies rely on small-molecule inhibitors targeting the initiation of lytic RCD but these show off-target effects and reduced pro-repair ...
Zhenxiang Huang, Qingqing Wang, Yiyu Chen, Jiahao Zhu, Jiachen Xu, Yang Yang, Yongcheng Wang, Ke Yang, Huige Yan, Mobai Li, Anlan Yang, Liqing Shangguan, Chenhui Gu, Shunwu Fan, Pengfei Chen, Xianfeng Lin   +15 more
doaj   +1 more source

Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair

, 2010
Rapid plasma membrane resealing is essential for cellular survival. Earlier studies showed that plasma membrane repair requires Ca2+-dependent exocytosis of lysosomes and a rapid form of endocytosis that removes membrane lesions.
Vincent Idone, Christina Tam, Tam, Christina, Schuchman, Edward, Edward Schuchman, He, Xingxuan, Devlin, Cecilia, Xingxuan He, Ira Tabas, Tabas, Ira, Fernandes, Maria Cecilia, Cecilia Devlin, Andrew Flannery, Norma W. Andrews, Andrews, Norma W., Idone, Vincent, Flannery, Andrew, Maria Cecilia Fernandes   +17 more
core   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

Membrane injury and repair in the muscular dystrophies

, 2015
Muscle cells have an elaborate plasma membrane and t-tubule system that has been evolutionarily refined to maximize electrical conductivity for synchronous muscle contraction.
Cooper, Sandra T., Head, Stewart I. (R14226)   +1 more
core   +1 more source

Investigation of Complement Activation and Cytokine Signatures in AQP4+ NMOSD, MOGAD, and MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Aquaporin‐4‐IgG seropositive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), and multiple sclerosis (MS) are pathophysiologically distinct neuroinflammatory disorders. Complement activation is a major mechanism of injury in AQP4+ NMOSD, whereas its role in
Angeliki G. Filippatou, Susana Dominguez‐Penuela, David Acero‐Garces, Georgios Gakis, Matthew D. Smith, Yasmin Resto, Maria Reyes‐Mantilla, Haiwen Chen, Isabella Hernandez, Yana Said, Andrea Salazar‐Camelo, Christina Huynh, Alessia Tassoni, Ted Yednock, Rick Artis, Yaisa Andrews‐Zwilling, Scott D. Newsome, Shiv Saidha, Pavan Bhargava, Ellen M. Mowry, Kathryn C. Fitzgerald, Peter A. Calabresi, Carlos A. Pardo, Elias S. Sotirchos   +23 more
wiley   +1 more source

Plasma membrane damage causes cellular senescence

Suda and colleagues explore the enduring consequences of plasma membrane injury in budding yeast and mammalian cells. Their findings highlight that membrane damage induces irreversible cell-cycle arrest and premature cellular senescence, whereas ...
Nylandsted, Jesper, Sønder, Stine Lauritzen   +1 more
core   +1 more source

Nanosecond pulsed electric fields induce cell-size-dependent selective permeabilization of urothelial cancer cells

Communications Biology
Plasma membrane integrity is vital for cell viability, yet its controlled disruption enables targeted delivery of therapeutic agents. Here, we examined membrane durability and repair capacity in normal and malignant urothelial cells using short, high ...
Aleksander Kielbik, Emily Hellwich, Veronika Bahlinger, Pamela Sowa, Daniel Lambton, Markus Kühs, Maria Luisa Barcena, Olesya Vakhrusheva, Hendrik Proebsting, Simon Walz, Tilman E. Schäffer, Falko Fend, Vitalij Novickij, Bastian Amend, Igor Tsaur   +14 more
doaj   +1 more source