Results 41 to 50 of about 1,320,101 (268)

Influence of plasma shaping on n = 4 RMP response in EAST

Nuclear Fusion
The effect of plasma shaping on the n  = 4 resonant magnetic perturbation (RMP) response in EAST is investigated using the resistive magnetohydrodynamic code MARS-F (Liu et al 2010 Phys.
Cheng Ye, You-Wen Sun, Shuai Gu, Hui-Hui Wang, Yue-Qiang Liu, Peng-Cheng Xie, Jian Xu, Hui Sheng, Tian-Yang Xia   +8 more
doaj   +1 more source

Decoding the evolutionary response to prostate cancer therapy by plasma genome sequencing

Genome Biology, 2020
Background Investigating genome evolution in response to therapy is difficult in human tissue samples. To address this challenge, we develop an unbiased whole-genome plasma DNA sequencing approach that concurrently measures genomic copy number and exome ...
Naveen Ramesh, Emi Sei, Pei Ching Tsai, Shanshan Bai, Yuehui Zhao, Patricia Troncoso, Paul G. Corn, Christopher Logothetis, Amado J. Zurita, Nicholas E. Navin   +9 more
doaj   +1 more source

Vasopressin surrogate marker copeptin as a potential novel endocrine biomarker for antidepressant treatment response in major depression: A pilot study

European Psychiatry, 2021
Introduction Major depressive disorder (MDD) constitutes the leading cause of disability worldwide. Although efficacious antidepressant pharmacotherapies exist for MDD, only about 40-60% of the patients respond to initial treatment.
A. Agorastos, A. Sommer, K. Wiedemann, C. Demiralay   +3 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Linear and quasi-linear modeling in view of ELM control in MAST-U including effects of error fields

Nuclear Fusion
Edge localized modes (ELMs) pose a critical challenge to the safety and performance of plasma-facing components in tokamaks due to their periodic expulsion of heat and particles.
E. Tomasina, M.J. Markl, L. Pigatto, D. Ryan, A. Kirk, C.G. Albert, E. Viezzer, Y.Q. Liu, T. Bolzonella, MAST-U Team, the EUROfusion Tokamak Exploitation Team   +10 more
doaj   +1 more source

Determinants of plasma cholesterol responsiveness to diet [PDF]

British Journal of Nutrition, 1994
Plasma cholesterol change, or ‘responsiveness’, to dietary saturated fat modification has long been acknowledged. The present study sought to determine the specific, predicted response of each cholesterol subfraction to known dietary manipulations. Two metabolically controlled diets, one with a low polyunsaturated:saturated fat (low P:S) ratio, and one
M M, Cobb, H, Teitlebaum
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Plasma YKL-40 and NGAL are useful in distinguishing ACO from asthma and COPD

Respiratory Research, 2018
Background Asthma-chronic obstructive pulmonary disorder (COPD) overlap (ACO) is characterized by the coexistence of features of both asthma and COPD and is associated with rapid progress and a poor prognosis.
Jing Wang, Huajie Lv, Zhuang Luo, Shan Mou, Jing Liu, Chang Liu, Shiying Deng, Youfan Jiang, Jiachen Lin, Chengzhou Wu, Xianhong Liu, Jinzhi He, Depeng Jiang   +12 more
doaj   +1 more source

Identification of plasma microRNA-22 as a marker for the diagnosis, prognosis, and chemosensitivity prediction of osteosarcoma

Journal of International Medical Research, 2020
Objective MicroRNA (miR)-22 plays crucial roles in malignant tumors and is involved in regulation of chemosensitivity. Additionally, altered expression of circulating miR-22 has been reported in various cancers.
Zhen-bin Diao, Tian-xiao Sun, Yi Zong, Bo-chuan Lin, Yuan-sheng Xia   +4 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source