Results 121 to 130 of about 1,518,880 (297)

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Degradable plasma polymerized poly (ethylene glycol)-like coatings as a matrix for controlled-release of components in food related applications

, 2023
Here we employed an atmospheric pressure aerosol-assisted plasma deposition method to develop a biodegradable PEG-like coating for controlled-release applications.Different plasma operating parameters were optimized, including; power, monomer flow rate ...
Ragaert, PeterLA230019961942218010015861100000-0002-0044-2322F655A0B0-F0ED-11E1-A9DE-61C894A0A6B4, Nikiforov, AntonTW178010019612750000-0002-2255-6419FC16D280-F0ED-11E1-A9DE-61C894A0A6B4, Nilkar, MaryamTW170002203434798020036678480000-0002-8296-8271eb4ba084-7ae1-11eb-9feb-dd9f9785dee4, De Geyter, NathalieTW170019990807778010018627600000-0001-7883-5786F7211902-F0ED-11E1-A9DE-61C894A0A6B4, Zabihzadeh Khajavi, MaryamLA230002014247428020036048979021bf69-22df-11eb-b7c5-8bb6d9ed9fea, Devlieghere, FrankLA238010009094330000-0003-3754-1225F4B603C6-F0ED-11E1-A9DE-61C894A0A6B4   +5 more
core  

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Blood and blood substitutes [PDF]

, 1977
Doenicke, A., Lorenz, Wilfried, Grote, B.   +2 more
core   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

3D minichannel-morphed adipose stem cell-cartilage granule reconstituted tough grafts for repairing segmental tracheal defects in preclinical models

Nature Communications
Segmental tracheal reconstruction requires biomimetic substitutes that replicate both the rigid stenting of cartilage rings and the nutritional support of vascularized fascia.
Xinchi Zhang, Na Wei, Bing Liu, Pingping Yuan, Xiaopeng Wu, Zheqian Zhang, Yidong Hu, Pengyu Wang, Jingyi Zhang, Yimin Zhao, Wei Wu   +10 more
doaj   +1 more source

EC9916 Substitutes for Crackers [PDF]

, 1936
Extension Circular 9916 This circular is about substitutes for ...

core  

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source