Results 131 to 140 of about 45,338 (267)

Causal Association Between Immune Cells and Cervical Cancer: A Two-Sample Mendelian Randomization Study

Zhongliu Fangzhi Yanjiu
ObjectiveTo investigate potential causative associations between immunophenotype traits and cervical cancer by using two-sample Mendelian randomization (MR) analysis.
Jingting LIU, Yawei ZHOU, Lingguo KONG, Qiandan WANG, Tianxiong SU, Jianying PEI, Yan LI   +6 more
doaj   +1 more source

An Immune Dysfunction Signature Score Predicts Survival in MDS Patients: Insights From a Longitudinal, Multicenter Study

Cancer Science, EarlyView.
An immune dysfunction score (IDS) provides independent prognostic information in MDS and CMML, complements current risk models, mirrors disease changes, and reflects underlying immune impairment. IDS may also highlight therapeutic sensitivities, supporting its use as a practical biomarker for risk stratification and clinical follow‐up.
Yu‐Hung Wang, Carmelo Gurnari, Valeria Visconte, Arda Durmaz, Luca Guarnera, Wan‐Hsuan Lee, Chi‐Yuan Yao, Andres Jerez, Kristian Gurashi, Kiran Batta, Hsin‐An Hou, Wen‐Chien Chou, Mrinal S. Patnaik, Jaroslaw Maciejewski, Daniel H. Wiseman, Chien‐Chin Lin, Hwei‐Fang Tien   +16 more
wiley   +1 more source

Tumor antigen cross-presentation and the dendritic cell: Where it all begins?

, 2010
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that are critical for the generation of effective cytotoxic T lymphocyte (CTL) responses; however, their function and phenotype are often defective or altered in tumor-bearing hosts ...
McDonnell, A.M., Robinson, B.W.S., Currie, A.J.   +2 more
core  

Organ‐Specific Cancer‐Associated Fibroblast Subtypes Across the Digestive System Linked to Cancer Hallmarks

Cancer Science, EarlyView.
We integrated 14 single‐cell RNA‐seq datasets and 18 bulk cohorts to define eight CAF subtypes in GI cancers. myCAF1 and myCAF2 promoted immunosuppressive, poor‐prognosis niches, whereas iCAF1 was linked to favorable prognosis and antitumor immunity.
Huaitao Wang, Takashi Semba, Atsuko Yonemura, Hiroshi Naito, Lingfeng Fu, Takuya Tajiri, Masaaki Iwatsuki, Takatsugu Ishimoto   +7 more
wiley   +1 more source

Irradiated Liver Cancer Cell Vaccine Transfected With GM‐CSF Induces Specific and Long‐Lasting Anti‐tumour Immunity Through the Synergistic Effect of Oxidised mtDNA and GM‐CSF

Cell Proliferation, EarlyView.
Song et al. developed an mGM‐CSF‐loaded, liver cancer cell‐based vaccine that potently activated dendritic cells and elicited tumour‐specific T cell responses. Mechanistically, radiation‐induced oxidative damage to mitochondrial DNA in cancer cells triggers the cGAS‐STING pathway in DCs, which synergizes with mGM‐CSF‐driven JAK2‐STAT3 signalling to ...
Zhiruo Song, Yujie Jiang, Yu Zhang, Danyi Ao, Chunjun Ye, Xiya Huang, Yingqiong Zhou, Hanle Yang, Ruolan Xia, Jiayuan Ai, Dandan Wan, Aiping Tong, Yuquan Wei, Xuemei He, Aqu Alu, Xiawei Wei   +15 more
wiley   +1 more source

Coronavirus non-structural protein 1 is a major pathogenicity factor : implications for the rational design of coronavirus vaccines

, 2007
Zust, Roland Cervantes-Barragan, Luisa Kuri, Thomas Blakqori, Gjon Weber, Friedemann Ludewig, Burkhard Thiel, Volker 5 R21 AI062246/AI/United States NIAID Research Support, N.I.H., Extramural Research Support, Non-U.S.
Thiel Volker, Friedemann Weber, Cervantes-Barragan, L., Kuri, Thomas, Roland Züst, Kuri Thomas, Weber, Friedemann, Weber, F., Volker Thiel, Luisa Cervantes-Barragán, Kuri, T., Zust, R., Ludewig, Burkhard, Blakqori, Gjon, Gjon Blakqori, Ludewig Burkhard, Burkhard Ludewig, Cervantes-Barragán, Luisa, Weber Friedemann, Thiel, Volker, Thomas Kuri, Ludewig, B., Thiel, V., Züst, Roland, Blakqori Gjon, Züst Roland, Cervantes-Barragán Luisa   +26 more
core   +1 more source

Discoid Lupus Erythematosus in Genital Skin: A Case Report and Review of the Literature

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Background Discoid lupus erythematosus (DLE) represents the most common variant of chronic cutaneous lupus erythematosus, a skin‐specific autoimmune disorder within the broader lupus erythematosus spectrum Clinically, DLE is characterized by erythematous, scaly plaques with areas of hyperpigmentation.
Ala' Abu‐Dayeh, Daniel Miller, Alessio Giubellino   +2 more
wiley   +1 more source

Regulatory mechanisms inhibiting anti-mycobacterial immunity following Mycobacterium tuberculosis infection.

, 2007
The work reported in this thesis addresses the regulatory factors that function to limit the initiation of protective immune responses following exposure to the bacterium Mycobacterium tuberculosis (MTb). Control and clearance of intracellular pathogens,
Redford, P.S.
core  

Ontogeny and Function of Plasmacytoid Dendritic Cells

Annual Review of Immunology
Plasmacytoid dendritic cells (pDCs) represent a unique cell type within the innate immune system. Their defining property is the recognition of pathogen-derived nucleic acids through endosomal Toll-like receptors and the ensuing production of type I interferon and other soluble mediators, which orchestrate innate and adaptive responses.
Nicholas M, Adams, Annesa, Das, Tae Jin, Yun, Boris, Reizis   +3 more
openaire   +2 more sources

GCN2 in proteostasis: structural logic, signalling networks and disease

The FEBS Journal, EarlyView.
Threats to protein synthesis activate the kinase GCN2, initiating the integrated stress response (ISR). GCN2 is triggered by stalled ribosomes and uncharged tRNAs, which accumulate when amino acids are scarce. The ISR adjusts cellular physiology by promoting redox balance, protein quality control, and mitochondrial optimisation.
JiaYi Zhu, Stefan J. Marciniak
wiley   +1 more source