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Plasmacytoid Dendritic Cell Development
2013Interferon-producing plasmacytoid dendritic cells (pDC) are a specialized branch of the dendritic cell (DC) family, and their differentiation in mice is closely linked to that of conventional DC (cDC). Several different developmental pathways retain the potential to form pDC and are likely to contribute to the steady-state pDC population.
Ken, Shortman +4 more
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Activation of plasmacytoid dendritic cells
Immunology & Cell Biology, 2005Four years after the discovery of mouse plasmacytoid dendritic cells (pDC), pDC are still very much an ‘enigmatic’ cell type. It is clear that pDC are potent producers of type I IFN in response to viral, bacterial and even mammalian nucleotides. The role that they play in vivo before and after activation is still under scrutiny.
Martina, Fuchsberger +2 more
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Blastic Plasmacytoid Dendritic-Cell Neoplasm
New England Journal of Medicine, 2020Blastic Plasmacytoid Dendritic-Cell Neoplasm A 29-year-old man presented with progressive skin lesions on the face, back, trunk, and limbs.
Yung Gonzaga, Mayne Fontes
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Blastic Plasmacytoid Dendritic Cell Neoplasm
Journal of the National Comprehensive Cancer Network, 2023Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with an aggressive clinical course and poor prognosis. BPDCN is most often characterized by its presentation with distinct cutaneous lesions. Bone marrow involvement, lymphadenopathy, splenomegaly, and/or cytopenias are also seen to varying degrees.
Akriti, Jain, Kendra, Sweet
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Plasmacytoid dendritic cells in autoimmunity
Current Opinion in Immunology, 2017Plasmacytoid dendritic cells (pDC) is a unique cell population that produces large amounts of type I interferon upon recognition of nucleic acids placing them at the crossroad of both innate and adaptive immunity. Their ability to produce interferon makes them central to anti-viral responses. They are also responsive to circulating autoantibodies bound
Santosh K, Panda +2 more
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Plasmacytoid dendritic cells in immunity
Nature Immunology, 2004Human and mouse plasmacytoid dendritic cells have been shown to correspond to a specialized cell population that produces large amounts of type I interferons in response to viruses, the so-called natural interferon-producing cells. As a result, intensive investigation is now focused on the potential functions of plasmacytoid dendritic cells in both ...
Marco, Colonna +2 more
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Plasmacytoid dendritic cells: origin matters
Nature Immunology, 2018Plasmacytoid dendritic cells (pDCs) are type I interferon–producing cells with antigen-presenting potential. pDC populations are composed of transcriptionally and functionally heterogeneous cellular subsets with distinct hematopoietic precursor origin.
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Blastic Plasmacytoid Dendritic Cell Neoplasm
Current Treatment Options in Oncology, 2019While there is a high initial response rate with standard chemotherapeutic regimens for blastic plasmacytoid dendritic cell neoplasm (BPDCN), the responses are typically not durable and this remains a very aggressive disease with generally poor outcomes.
Daniel, Kerr +2 more
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