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Plasmacytoid dendritic cells: the key to CpG
Human Immunology, 2002The vertebrate immune system has established TLR9 to detect microbial DNA based on unmethylated CG dinucleotides within certain sequence contexts (CpG motifs). In humans, the expression of toll-like receptor 9 (TLR9) is restricted to B cells and plasmacytoid dendritic cells (PDC).
Simon, Rothenfusser +3 more
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Human and mouse plasmacytoid dendritic cells
Human Immunology, 2002By virtue of their enormous potential to produce type I interferons it is clear that plasmacytoid dendritic cells are major players in the host defense against viruses and various pathogens. Plasmacytoid dendritic cells were first identified in humans and very recently the mouse equivalents have been isolated.
Hubertus, Hochrein +2 more
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Blastic Plasmacytoid Dendritic Cell Neoplasm
Current Treatment Options in Oncology, 2019While there is a high initial response rate with standard chemotherapeutic regimens for blastic plasmacytoid dendritic cell neoplasm (BPDCN), the responses are typically not durable and this remains a very aggressive disease with generally poor outcomes.
Daniel, Kerr +2 more
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Plasmacytoid dendritic cells in cutaneous sarcoidosis.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2018While absent from normal skin, plasmacytoid dendritic cells (pDCs) infiltrate the skin in several infectious, inflammatory, and neoplastic entities. In addition to providing anti-viral resistance, pDCs link the innate and adaptive immune responses. Sarcoidosis is an idiopathic multi-system granulomatous disease characterized by epitheliod granulomas ...
Halawi, Ali +2 more
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Plasmacytoid dendritic cells and autoimmune inflammation
bchm, 2013Abstract Plasmacytoid dendritic cells (pDC) are a sub-population of dendritic cells (DC) that produce large amounts of type I interferon (IFN) in response to nucleic acids that bind and activate toll-like-receptor (TLR)9 and TLR7. Type I IFN can regulate the function of B, T, DC, and natural killer (NK) cells and can also alter the ...
Georgina, Galicia, Jennifer L, Gommerman
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Plasmacytoid Dendritic Cell Leukemia in Children
Journal of Pediatric Hematology/Oncology, 2009CD4/CD56 malignancies are rare hematologic neoplasms, which have recently been shown to represent the malignant counterpart of plasmacytoid dendritic cells (pDC). A 5-year-old boy initially presented with multiple subcutaneous lesions on his upper and lower extremities. Skin biopsy results showed large atypical lymphoid cells in the dermis.
Asahito, Hama +9 more
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Role of Plasmacytoid Dendritic Cells in Cancer
2020In the last decade, several studies have provided evidence that plasmacytoid dendritic cells (pDCs) actively participate in a wide spectrum of human diseases including infection, autoimmunity, and cancer. In particular, human neoplasms are populated by pDCs, whose presence is related to a poor prognosis.
Terlizzi M +3 more
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The multifaceted murine plasmacytoid dendritic cell
Human Immunology, 2002Plasmacytoid dendritic cells (PDCs) or natural interferon-producing cells, function as the body's innate defense against viral infections. As discussed here, they may play additional roles in response to bacterial pathogens and may have the capacity to induce different type of T-cell responses depending on what signals they receive.
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Reclassification of plasmacytoid dendritic cells as innate lymphocytes is premature
Nature Reviews Immunology, 2023Boris Reizis +2 more
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Reply to ‘Reclassification of plasmacytoid dendritic cells as innate lymphocytes is premature’
Nature Reviews Immunology, 2023Loems Ziegler-Heitbrock +2 more
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