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Fitness Costs of Plasmids: a Limit to Plasmid Transmission [PDF]
Microbiology Spectrum, 2017 ABSTRACT Plasmids mediate the horizontal transmission of genetic information between bacteria, facilitating their adaptation to multiple environmental conditions. An especially important example of the ability of plasmids to catalyze bacterial adaptation and evolution is their instrumental role in the global spread of antibiotic resistance ...
San Millan, A, Maclean, R
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Plasmid persistence: costs, benefits, and the plasmid paradox [PDF]
Canadian Journal of Microbiology, 2018 Plasmids are extrachromosomal DNA elements that can be found throughout bacteria, as well as in other domains of life. Nonetheless, the evolutionary processes underlying the persistence of plasmids are incompletely understood. Bacterial plasmids may encode genes for traits that are sometimes beneficial to their hosts, such as antimicrobial resistance ...
Amanda C. Carroll, Alex Wong
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Cloning and expression of Toxoplasma gondii GRA-4 recombinant protein as a toxoplasmosis diagnostic kit candidate [PDF]
Veterinary World, 2020 Aim: The objective of this study was to produce recombinant protein GRA-4 (rGRA-4) of a local Toxoplasma gondii isolate as a candidate for a toxoplasmosis diagnosis kit in Escherichia coli BL21 (DE3) competent cells using pET SUMO plasmid.
Muhammad Hanafiah +4 more
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Frontiers in Microbiology, 2021 Spread of the carbapenemase-encoding and mobilized colistin resistance (mcr) genes among Enterobacteriales poses a great threat to global public health, especially when the both genes are transferred by a single plasmid.
Zhou Liu +13 more
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mSphere, 2021 The spread of Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacterales is a public health concern. KPC-encoding blaKPC is predominantly spread by strains of a particular phylogenetic lineage, clonal group 258, but can also be spread by ...
Kayoko Sugita +6 more
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Microbiology and Molecular Biology Reviews, 2010 SUMMARYPlasmids are key vectors of horizontal gene transfer and essential genetic engineering tools. They code for genes involved in many aspects of microbial biology, including detoxication, virulence, ecological interactions, and antibiotic resistance.
Smillie, C. +4 more
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Plasmid, 2023 Plasmids are universally present in bacteria and play key roles in the dissemination of genes such as antibiotic resistance determinants. Major concepts in Plasmid Biology derive from the efforts to classify plasmids. Here, we review the main plasmid classification systems, starting by phenotype-based methods, such as fertility inhibition and ...
Garcillán-Barcia, M. Pilar +2 more
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Variability of plasmid fitness effects contributes to plasmid persistence in bacterial communities
Nature Communications, 2021 Plasmid persistence in bacterial populations is strongly influenced by the fitness effects associated with plasmid carriage. However, plasmid fitness effects in wild-type bacterial hosts remain largely unexplored. In this study, we determined the fitness
Aida Alonso-del Valle +8 more
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Nucleic Acids Research, 2021 Plasmids and temperate phages are key contributors to bacterial evolution. They are usually regarded as very distinct. However, some elements, termed phage–plasmids, are known to be both plasmids and phages, e.g. P1, N15 or SSU5. The number, distribution,
E. Pfeifer +3 more
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Genetic Diversity and Characteristics of blaNDM-Positive Plasmids in Escherichia coli
Frontiers in Microbiology, 2021 New Delhi metallo-β-lactamases (NDMs), including at least 28 variants, are a rapidly emerging family of β-lactamases worldwide, with a variety of infections caused by NDM-positive strains usually associated with very poor prognosis and high mortality ...
Zhiren Zhang +12 more
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