Results 231 to 240 of about 741,058 (313)

Elevation, soil pH and calcium availability shape regional and local scale spatial patterns of PhoD gene abundance in tropical and subtropical forests

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Organic phosphorus mineralization is a critical process in the phosphorus cycle, governing phosphorus bioavailability for plants. The PhoD gene, which encodes the key enzyme alkaline phosphatase, serves as a valuable biomarker for this process.
Sandhya Mishra, Shangwen Xia, Wenting Wang, Xiaodong Yang   +3 more
wiley   +1 more source

Mechanism of ITGB2 in Osteoclast Differentiation in Osteoarthritis

Cell Proliferation, EarlyView.
In osteoclast precursors, higher ITGB1 than ITGB2 expression increases ITGA2‐ITGB1 integrin. In OA, extracellular signals upregulate ITGB2 and downregulate ITGB1, enhancing ITGA2‐ITGB2 integrin. This activates Rac1 to Rac‐GTP, driving osteoclast differentiation. Hyperactive subchondral osteoclasts accelerate OA progression.
Yang Yang, Rui Sun, Zhibin Lan, Qi Ma, Gang Wu, Di Xue, Zhirong Chen, Yajing Su, Ye Ma, Xiaolei Chen, Jiangbo Yan, Long Ma, Xiaoxin He, Kuanmin Tian, Xiaoyi Ma, Xue Lin, Qunhua Jin   +16 more
wiley   +1 more source

DNA supercoiling enhances DNA condensation by ParB proteins. [PDF]

Nucleic Acids Res
Martin-Gonzalez A, Tišma M, Analikwu BT, Barth A, Janissen R, Antar H, Kemps G, Gruber S, Dekker C.   +8 more
europepmc   +1 more source

Mitophagy and Bip–PERK–eIF2α–ATF4 Axis‐Mediated ER Stress Mediate Miriplatin‐Loaded Liposome's Anti‐Colorectal Cancer Action

Cell Proliferation, EarlyView.
LMPt enters the cell mainly through caveolin‐mediated endocytosis, and then fuses with endosomes and lysosomes to deliver MPt to mitochondria and the endoplasmic reticulum to induce mitophagy based on the fusion of lysosomes and mitochondria, and endoplasmic reticulum stress and subsequent apoptosis via the Bip–PERK–eIF2α–ATF4 axis to exert an anti ...
Cong Zhao, Yuhan Qiu, Xiaowei Wang, Mengyan Wang, Li Liu, Xiaojun Zhao, Zixiang Gao, Rongguang Shao, Guimin Xia, Wuli Zhao   +9 more
wiley   +1 more source

Steric repulsion counteracts ER-to-lipid droplet protein movement. [PDF]

Sci Adv
Damm A, Omrane M, Stojanović O, Esch BM, Zouiouich M, Carpentier M, Klemm R, Fröhlich F, Forêt L, Thiam AR.   +9 more
europepmc   +1 more source

The depletion of serine beta‐lactamase‐like protein (LACTB) ameliorates metabolic dysfunction–associated steatotic liver disease by reducing ubiquitin‐mediated degradation of carnitine palmitoyltransferase 2

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Metabolic dysfunction–associated steatotic liver disease (MASLD) represents one of the most common chronic liver disorders worldwide, and its incidence continues to rise each year. Serine β‐lactamase‐like protein (LACTB) is a serine protease that plays a crucial role in lipid metabolism and hepatocellular carcinoma, but its function in ...
Wujiang Shi, Xin Liu, Nan Wang, Qianwen Zhang, Jianjun Gao, Canghai Guan, Yapeng Li, Chengru Yang, Shaowu Bi, Xinlei Zou, Xiangyu Zhong   +10 more
wiley   +1 more source

Pico-Scale Digital PCR on a Super-Hydrophilic Microarray Chip for Multi-Target Detection. [PDF]

Micromachines (Basel)
Xian Q, Zhang J, Wong YC, Gao Y, Song Q, Xu N, Wen W.   +6 more
europepmc   +1 more source

Multiple cis‐regulatory elements collaborate to control mdka expression in telencephalic neural stem cells of adult zebrafish during constitutive and regenerative neurogenesis

The FEBS Journal, EarlyView.
midkine‐a (mdka), a pan‐injury response gene in vertebrates, is precisely regulated in the zebrafish telencephalon by a modular cis‐regulatory architecture. This control ensures proper expression during development, adult brain homeostasis, and regeneration.
Jincan Chen, Masanari Takamiya, Agnes Hendriks, Tanja Beil, Csilla Várnai, Nicolas Diotel, Sepand Rastegar   +6 more
wiley   +1 more source

Intracellular competitions reveal the combination of active partitioning and addiction mechanisms as most advantageous for low-copy plasmid fitness

Effe J, Santer M, Wang Y, Feenstra TE, Hülter NF, Dagan T.   +5 more
europepmc   +1 more source

The BRAF-specific region suppresses cysteine-rich domain-lipid interaction independently of canonical autoinhibition by the 14-3-3 dimer. [PDF]

Protein Sci
Revazishvili V, Morales A, Baxter B, Grim J, Chakhrakia A, Jimenez Salinas A, Tevdorashvili K, Riestra AM, Lee YK.   +8 more
europepmc   +1 more source