Results 51 to 60 of about 680,206 (303)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Phenotypic and genetic analysis of Klebsiella pneumoniae strains isolated from community-acquired pneumonia patients in Rostov-on-Don in 2021–2023

Инфекция и иммунитет
Introduction. Here, we present a study of 33 Klebsiella pneumoniae strains isolated in Rostov-on-Don in 2021–2023 from patients with community-acquired pneumonia.
Violetta A. Rykova, O. N. Podladchikova, A. S. Anisimova, N. V. Aronova, A. S. Vodopyanov, S. Yu. Temyakova, E. N. Gudueva   +6 more
doaj   +1 more source

Antimicrobial Resistance Genes, Cassettes, and Plasmids Present in Salmonella enterica Associated With United States Food Animals

Frontiers in Microbiology, 2019
The ability of antimicrobial resistance (AR) to transfer, on mobile genetic elements (MGEs) between bacteria, can cause the rapid establishment of multidrug resistance (MDR) in bacteria from animals, thus creating a foodborne risk to human health.
Elizabeth A. McMillan, Sushim K. Gupta, Laura E. Williams, Thomas Jové, Lari M. Hiott, Tiffanie A. Woodley, John B. Barrett, Charlene R. Jackson, Jamie L. Wasilenko, Mustafa Simmons, Glenn E. Tillman, Michael McClelland, Jonathan G. Frye   +12 more
doaj   +1 more source

Molecular analysis of transferable tetracycline resistance plasmids from Clostridium perfringens [PDF]

, 1985
Conjugative tetracycline resistance plasmids from 15 Clostridium perfringens isolates from piggeries were analyzed by restriction endonuclease digestion and agarose gel electrophoresis. Seven isolates from one farm were found to carry a 47-kilobase pair (
Rood, J.I., Abraham, L.J.
core  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Role of plasmids in antibiotic resistance in clinical infections and implications for epidemiological surveillance: a review

All Life
The global upsurge in antibiotic resistant bacteria (ARB) is putting immense pressure on healthcare. The spreading of antimicrobial resistance is facilitated by mobile genetic elements, most especially plasmids.
Ayodele Oluwaseun Ajayi, Olajide Joseph Akinjogunla, Adebowale Toba Odeyemi, Akinyomade Oladipo Owolabi   +3 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Replication of plasmids derived from Shiga toxinconverting bacteriophages in starved Escherichia coli [PDF]

, 2011
The pathogenicity of Shiga toxin-producing Escherichia coli (STEC) depends on the expression of stx genes that are located on lambdoid prophages. Effective toxin production occurs only after prophage induction, and one may presume that replication of the
Nejman, Bożena, Nadratowska-Wesołowska, Beata, Węgrzyn, Alicja, Węgrzyn, Grzegorz, Szalewska-Pałasz, Agnieszka   +4 more
core   +1 more source

The Identification, Isolation and Partial Characterisation of VapA-encoding virulence plasmids in Rhodococcus equi found in New Zealand. [PDF]

, 2010
This thesis describes the identification, isolation and partial characterisation of VapA-encoded virulence plasmids present in Rhodococcus equi (R. equi) found in foals in New Zealand. R.
Singh, Niharika
core  

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source