Results 121 to 130 of about 84,335 (338)

Chemical Adjustment of Fibrinolysis

Pharmaceuticals
Fibrinolysis is the process of the fibrin–platelet clot dissolution initiated after bleeding has been stopped. It is regulated by a cascade of proteolytic enzymes with plasmin at its core.
Alexey M. Shibeko, Ivan S. Ilin, Nadezhda A. Podoplelova, Vladimir B. Sulimov, Mikhail A. Panteleev   +4 more
doaj   +1 more source

Deletion of a Pax1 Sex‐Associated Genomic Region Associated With Adolescent Idiopathic Scoliosis Leads to Disc Degeneration, Instability, and Vertebral Rotation in Mice

JOR SPINE, Volume 9, Issue 2, June 2026.
Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody, Emma M. Wade, Shuji Mizumoto, Jeremy McCallum‐Loudeac, Megan J. Wilson   +4 more
wiley   +1 more source

Genetically conditioned interaction among microRNA‐155, alpha‐klotho, and intra‐renal RAS in male rats: Link to CKD progression

Physiological Reports
Incident chronic kidney disease (CKD) varies in populations with hypertension of similar severity. Proteinuria promotes CKD progression in part due to activation of plasminogen to plasmin in the podocytes, resulting in oxidative stress‐mediated injury ...
L. M. Harrison‐Bernard, L. Raij, R. X. Tian, E. A. Jaimes   +3 more
doaj   +1 more source

The Impact of the Fibrinolytic System on the Outcomes of Thrombolytic Therapy

Неотложная медицинская помощь
Thrombolysis is one of the effectively used methods for treating patients with acute vascular pathology. Despite the high technical success of this therapy, some problems of fibrinolytic treatment still remain unresolved.
R. E. Kalinin, E. A. Klimentova, I. A. Suchkov, A. A. Egorov, A. S. Pshennikov   +4 more
doaj   +1 more source

Hyperaldosteronism in Mice Lacking the Distal Polybasic Tract of the γ‐Subunit of the Epithelial Sodium Channel During Sodium Restriction

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aims The epithelial sodium channel ENaC consists of the subunits α, β, and γ and is activated at an individual channel level by proteolytic processing. Murine γENaC contains a distal polybasic tract 186RKRK mediating proteolytic ENaC activation by serine proteases in vitro.
Daniel Essigke, M. Zaher Kalo, Matthias Wörn, Xia‐Qing Li, Bernhard N. Bohnert, Anja Schork, Andreas L. Birkenfeld, Thomas Ott, Ferruh Artunc   +8 more
wiley   +1 more source

Recombinant chymase inhibits fibrinolysis induced by endogenous plasmin in clotted human blood

Frontiers in Immunology
BackgroundOur group recently reported that chymase, a serine protease synthetized and released by mast cells, plays a pivotal role in thrombi stabilization in murine deep vein thrombosis (DVT) models, by interfering with the fibrinolytic properties of ...
Laurence Vincent, Catherine Lapointe, Patrick P. McDonald, Christos Rammos, Tienush Rassaf, Maria Köllnberger, Hanna Tinel, Stefan Heitmeier, Pedro D’Orléans-Juste   +8 more
doaj   +1 more source

Electrochemical Detection of Thrombin Activity Using an Electrogenic Substrate: Toward Rapid Coagulation Monitoring

ChemElectroChem, Volume 13, Issue 9, 5 May 2026.
Measuring thrombin activity provides critical information about coagulation health. A voltammetry technique was developed to monitor thrombin activity rapidly on a screen‐printed gold electrode. Thrombin selectively cleaves the bond between para‐nitroaniline (pNA) and a tri‐peptide substrate. pNA cleavage is monitored electrochemically by measuring its
Sina Ardalan, Anna Ignaszak
wiley   +1 more source

ALDH1A3 promotes invasion and metastasis in triple‐negative breast cancer by regulating the plasminogen activation pathway

Molecular Oncology
Aldehyde dehydrogenase 1A3 (ALDH1A3) is a cancer stem cell marker that promotes metastasis. Triple‐negative breast cancer (TNBC) progression has been linked to ALDH1A3‐induced gene expression changes.
Alamelu G. Bharadwaj, Meghan E. McLean, Margaret L. Dahn, Hannah F. Cahill, Marie‐Claire D. Wasson, Raj Pranap Arun, Olivia L. Walker, Brianne M. Cruickshank, Wasundara Fernando, Jaganathan Venkatesh, Penelope J. Barnes, Gillian Bethune, Gregory Knapp, Lucy K. Helyer, Carman A. Giacomantonio, David M. Waisman, Paola Marcato   +16 more
doaj   +1 more source

Degradation of connective tissue matrices by macrophages. III. Morphological and biochemical studies on extracellular, pericellular, and intracellular events in matrix proteolysis by macrophages in culture. [PDF]

, 1980
We have shown that macrophages in culture degrade the glycoproteins and amorphous elastin of insoluble extracellular matrices. Ultrastructural observation of the macrophage-matrix interaction revealed that connective tissue macromolecules were ...
Bainton, DF, Jones, PA, Werb, Z
core  

Microfluidic Platform for Multiparametric Profiling of Fibrin Permeability, Fibrinolysis, and Cell Invasion

Advanced Functional Materials, Volume 36, Issue 37, 7 May 2026.
This paper introduces a single‐channel H‐junction microfluidic assay that profiles fibrin's evolving function in repair and thrombosis by measuring, in one ∼3 µL gel, permeability, fibrinolysis kinetics, fibroblast invasion, and clot extension in real time.
Halston Deal, Elizabeth M. Byrnes, Sanika Pandit, Halle J. Cantor, Muskan Aslam, Stacy Ban, Megan Palmisano, Rosemary Bayless, Ashley C. Brown, Michael Daniele   +9 more
wiley   +1 more source