Results 121 to 130 of about 36,053 (249)

Truncation of ADAMTS13 by Plasmin Enhances Its Activity in Plasma

, 2018
ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) cleaves von Willebrand Factor (VWF) multimers to control their thrombogenicity. The fibrinolytic enzyme plasmin can cleave VWF in a similar manner.
Tielens, Aloysius G M, Afd Chemical Biology and Drug Discovery, Hazenberg, Bouke P.C., de Maat, Steven, Hazenberg, Bouke P C; id_orcid, Clark, Chantal C, Dep Biochemie en Celbiologie, Clark, Chantal C., Van Hellemond, Jaap J., LS Veterinaire biochemie, Fijnheer, Rob, van Hellemond, Jaap J, Urbanus, Rolf T, Hazenberg, Bouke P C, de Groot, Philip G, Maas, Coen, Mebius, Mirjam M., Tielens, Aloysius G.M., Mebius, Mirjam M   +18 more
core   +1 more source

Recombinant chymase inhibits fibrinolysis induced by endogenous plasmin in clotted human blood

Frontiers in Immunology
BackgroundOur group recently reported that chymase, a serine protease synthetized and released by mast cells, plays a pivotal role in thrombi stabilization in murine deep vein thrombosis (DVT) models, by interfering with the fibrinolytic properties of ...
Laurence Vincent, Catherine Lapointe, Patrick P. McDonald, Christos Rammos, Tienush Rassaf, Maria Köllnberger, Hanna Tinel, Stefan Heitmeier, Pedro D’Orléans-Juste   +8 more
doaj   +1 more source

Hyperaldosteronism in Mice Lacking the Distal Polybasic Tract of the γ‐Subunit of the Epithelial Sodium Channel During Sodium Restriction

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aims The epithelial sodium channel ENaC consists of the subunits α, β, and γ and is activated at an individual channel level by proteolytic processing. Murine γENaC contains a distal polybasic tract 186RKRK mediating proteolytic ENaC activation by serine proteases in vitro.
Daniel Essigke, M. Zaher Kalo, Matthias Wörn, Xia‐Qing Li, Bernhard N. Bohnert, Anja Schork, Andreas L. Birkenfeld, Thomas Ott, Ferruh Artunc   +8 more
wiley   +1 more source

Skin Boosters: 2026 Updated

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Skin boosters are increasingly used to improve dermal quality through injectable and device‐assisted approaches; however, definitions and clinical evidence remain heterogeneous. Aims To provide an updated overview and propose a practical classification of skin boosters, including mechanisms, delivery methods, clinical outcomes, and limitations.
Kyu‐ho Yi, Hyunggyu Kang, Jong Keun Song, Olena Sydorchuk, Jeremy B. Green, Hugues Cartier, Roya Zarmehr Zamin, Benjamin Ascher   +7 more
wiley   +1 more source

Comparison of the Efficacy of Kligman's Formula Combined With 30% Topical Metformin Versus Kligman's Formula Alone in the Treatment of Melasma

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Melasma is a common hyperpigmentation disorder primarily affecting women, influenced by ultraviolet exposure, hormones, and genetics. Kligman's formula is a first‐line therapy, but emerging evidence suggests that topical metformin, an antidiabetic with antimelanogenic effects, may enhance treatment outcomes.
Fariba Iraji, Fatemeh Mokhtari, Zeinab Kassab, Sarah Seyedyousefi, Jaleh Varshosaz   +4 more
wiley   +1 more source

Coamatic® plasmin inhibitor: a new specific method for determination of plasmin inhibitor activity in plasma

, 1996
It has recently been described that many commercial methods for the determination of plasmin inhibitor (PI) activity are not specific at low plasmin inhibitor concentrations (1, 2).
Ersdal, E., Kluft, C., Clason, S.B., Meijef, P.   +3 more
core  

Limited proteolysis of tumor cells increases their plasmin-binding ability

, 1989
Mild proteolytic treatment of SW 1116 tumor cells with trypsin or plasmin increases their plasmin-binding ability considerably by increasing the number of binding sites without altering their affinity.
Mercedes Camacho, Fondaneche, Marie-Claude, Marie-Claude Fondaneche, Camacho, Mercedes, Pierre Burtin, Burtin, Pierre   +5 more
core   +1 more source

Mechanistic Review of Topical Therapies Targeting Dermal Fibroblasts in Skin Aging and Rejuvenation

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Skin aging appears in multiple forms, including wrinkles, sagging, scarring, atrophy, and photoaging. Although each phenotype has distinct biological features, all are rooted in dermal fibroblast dysfunction. This review examines the molecular pathways underlying these conditions and evaluates topical interventions designed to ...
Seyedeh Melika Akaberi, Mohammad Esfandiyari, Hamid Reza Ahmadi Ashtiani   +2 more
wiley   +1 more source

Analysis of the interaction between α2-antiplasmin and plasmin(ogen)

, 2017
Plasminogen is a multi-domain molecule which consists of a pan-apple domain, five kringles and a serine protease domain. Activation of plasminogen to plasmin converts the zymogen to a potent enzyme which dissolves blood clots.
Lu, Bernadine Gueh Cheng (3798910)
core   +1 more source

Acute obstetric coagulopathy is associated with excess plasmin generation and proteolysis of fibrinogen and factor V

Blood Advances
: Hemostatic impairment may exacerbate postpartum hemorrhage (PPH). Previously, we described a distinct coagulopathy, associated with multiple causes of PPH including placental abruption and amniotic fluid embolus, termed acute obstetric coagulopathy ...
Peter W. Collins, Claire S. Whyte, Lucy de Lloyd, Anuj Narwal, Sarah F. Bell, Nicholas Gill, Rachel E. Collis, Peter V. Jenkins, Nicola J. Mutch   +8 more
doaj   +1 more source