Results 111 to 120 of about 39,772 (244)

Regulation of macrophage receptor-bound plasmin by autoproteolysis

, 1994
The activation of plasminogen by macrophage is regulated by their expression of receptors for urokinase and plasmin(ogen). In these studies we have examined plasmin(ogen) binding to adherent human THP-1 macrophage.
Mathew, J., Falcone, D. J., McAdam, K., Borth, W., McCaffrey, T. A.   +4 more
core  

Plasmin activity assay based on luciferase activity

, 2012
Pilot experiment with the Plasmin-Glo ...
Per Svenningsen (99861)
core   +1 more source

Efficacy and safety of argatroban combined with plasmin in the treatment of acute cerebral infarction

Zhongguo linchuang yanjiu
Objective To observe the effects of combined application of argatroban and plasmin on the degree of neurological function deficit and neutrophil (NEUT) count in patients with acute cerebral infarction (ACI) and their safety.
HU Tao*, CAO Hong
doaj   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, Volume 183, Issue 22, Page 6607-6626, November 2026.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Plasminogen and plasmin in Alzheimer's disease

, 2010
In Alzheimer's disease, abnormal accumulation of Aβ leads to neuronal death and impaired Aβ degradation may play an important role in this accumulation. Plasmin is the key active protease in the plasminogen system and is capable of cleaving Aβ.
Barker, Rachel, Seth Love, Love, Seth, Patrick G. Kehoe, Rachel Barker, Kehoe, Patrick G   +5 more
core   +1 more source

Urinary plasmin activates collecting duct ENaC current in preeclampsia

, 2012
In nephrotic syndrome, plasminogen is aberrantly filtered from plasma to the urinary space and activated along the tubular system. In vitro, plasmin increases ENaC current by proteolytic cleavage of the γ-subunit. It was hypothesized that preeclampsia is
Ovesen, Per Glud, Jensen, Boye L, Svenningsen, Per; id_orcid, Frederiksen-Møller, Britta, Jespersen, Bente, Friis, Ulla G, Gulaveerasingam, Ambika, Bistrup, Claus; id_orcid, Buhl, Kristian B   +8 more
core   +1 more source

Tranexamic acid impairs plasmin generation on human mesenchymal stem cells and derived membrane microvesicles, halting pericellular proteolysis

Frontiers in Medicine
IntroductionMesenchymal stem cells (MSCs) participate in the dynamic remodeling of the extracellular matrix during wound healing, natural bleeding processes or cancer progression.
Ramy Abou Rjeily, Christina Mrad, Fatiha Z. El-Ghazouani, Florence Toti, Audrey Cras, Audrey Cras, Eduardo Angles-Cano   +6 more
doaj   +1 more source

Intravitreal autologous plasmin as a therapeutic modality for diffuse diabetic macular edema

, 2012
Moataz F ElsawyOphthalmology Department, Faculty of Medicine, Menofia University, Menofia, EgyptObjectives: To evaluate the outcome of vitreolysis using intravitreal autologous plasmin (IAP) injection as a sole therapeutic modality for patients with ...
Elsawy MF
core  

Mhp182 (P102) binds fibronectin and contributes to the recruitment of plasmin(ogen) to the Mycoplasma hyopneumoniae cell surface

, 2011
Mycoplasma hyopneumoniae is a major, economically damaging respiratory pathogen. Although M. hyopneumoniae cells bind plasminogen, the identification of plasminogen-binding surface proteins and the biological ramifications of acquiring plasminogen ...
Dixon, Nicholas E, Woolley, Lauren K., Raymond, Benjamin B. A., Tacchi, Jessica L, Graeme J. Eamens, Jenkins, Cheryl, Seymour, Lisa M, Daniel R. Bogema, Benjamin B. A. Raymond, Padula, Matthew P., Walker, Mark J, Deutscher, Ania T, Djordjevic, SP, Deutscher, AT, Bogema, DR, Deutscher, Ania T., Djordjevic, Steven P., Seymour, LM, Djordjevic, Steven P, Bogema, Daniel R, Walker, Mark J., Tacchi, JL, Jenkins, C, Matthew P. Padula, Mark J. Walker, Ania T. Deutscher, Steven P. Djordjevic, Eamens, Graeme J., Woolley, Lauren K, Padula, MP, Bogema, Daniel R., Dixon, Nicholas E., Eamens, Graeme J, Woolley, LK, Cheryl Jenkins, Jessica L. Tacchi, Raymond, BBA, Lauren K. Woolley, Walker , Mark J., Nicholas E. Dixon, Seymour, Lisa M., Walker, MJ, Tacchi, Jessica L., Raymond, Benjamin B. A, Dixon, NE, Lisa M. Seymour, Eamens, GJ, Padula, Matthew P   +47 more
core   +1 more source

Recombinant chymase inhibits fibrinolysis induced by endogenous plasmin in clotted human blood

Frontiers in Immunology
BackgroundOur group recently reported that chymase, a serine protease synthetized and released by mast cells, plays a pivotal role in thrombi stabilization in murine deep vein thrombosis (DVT) models, by interfering with the fibrinolytic properties of ...
Laurence Vincent, Catherine Lapointe, Patrick P. McDonald, Christos Rammos, Tienush Rassaf, Maria Köllnberger, Hanna Tinel, Stefan Heitmeier, Pedro D’Orléans-Juste   +8 more
doaj   +1 more source