Results 91 to 100 of about 36,053 (249)

Plasminogen activation in the musculoskeletal acute phase response: Injury, repair, and disease

Research and Practice in Thrombosis and Haemostasis, 2020
The musculoskeletal system is critical for movement and the protection of organs. In addition to abrupt injuries, daily physical demands inflict minor injuries, necessitating a coordinated process of repair referred to as the acute‐phase response (APR ...
Breanne H.Y. Gibson, Matthew T. Duvernay, Stephanie N. Moore‐Lotridge, Matthew J. Flick, Jonathan G. Schoenecker   +4 more
doaj   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, EarlyView.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Fibrinogenolytic and fibrinolytic activity of cell-associated plasmin.

, 1993
Binding of plasmin(ogen) to rat C6 glioma cells is saturable and kringle-domain dependent. This interaction was studied as a model of plasmin(ogen) receptor interactions in nucleated mammalian cells.
S L Gonias, J Vasudevan, J E Humphries
core   +1 more source

When proteases reshape barriers: Basement membrane remodelling in development, wound healing and tumour progression

The FEBS Journal, EarlyView.
Basement membrane (BM) homeostasis relies on a balance between integrity, controlled remodelling and pathological degradation. Increased protease expression beneath the BM, along with reduced levels of endogenous protease inhibitors, drives the transition from a continuous, protective barrier to a discontinuous interface.
Clara Legendre, Guila Dayan, Patricia Rousselle   +2 more
wiley   +1 more source

Mhp182 (P102) binds fibronectin and contributes to the recruitment of plasmin(ogen) to the Mycoplasma hyopneumoniae cell surface

, 2011
Mycoplasma hyopneumoniae is a major, economically damaging respiratory pathogen. Although M. hyopneumoniae cells bind plasminogen, the identification of plasminogen-binding surface proteins and the biological ramifications of acquiring plasminogen ...
Dixon, Nicholas E, Woolley, Lauren K., Raymond, Benjamin B. A., Tacchi, Jessica L, Graeme J. Eamens, Jenkins, Cheryl, Seymour, Lisa M, Daniel R. Bogema, Benjamin B. A. Raymond, Padula, Matthew P., Walker, Mark J, Deutscher, Ania T, Djordjevic, SP, Deutscher, AT, Bogema, DR, Deutscher, Ania T., Djordjevic, Steven P., Seymour, LM, Djordjevic, Steven P, Bogema, Daniel R, Walker, Mark J., Tacchi, JL, Jenkins, C, Matthew P. Padula, Mark J. Walker, Ania T. Deutscher, Steven P. Djordjevic, Eamens, Graeme J., Woolley, Lauren K, Padula, MP, Bogema, Daniel R., Dixon, Nicholas E., Eamens, Graeme J, Woolley, LK, Cheryl Jenkins, Jessica L. Tacchi, Raymond, BBA, Lauren K. Woolley, Walker , Mark J., Nicholas E. Dixon, Seymour, Lisa M., Walker, MJ, Tacchi, Jessica L., Raymond, Benjamin B. A, Dixon, NE, Lisa M. Seymour, Eamens, GJ, Padula, Matthew P   +47 more
core   +1 more source

Plasmin reduces fibronectin deposition by mesangial cells in a protease-activated receptor-1 independent manner

Biochemistry and Biophysics Reports, 2017
Background: Protease-activated receptor-1 (PAR-1) potentiates diabetic nephropathy (DN) as evident from reduced kidney injury in diabetic PAR-1 deficient mice. Although thrombin is the prototypical PAR-1 agonist, anticoagulant treatment does not limit DN
Maaike Waasdorp, JanWillem Duitman, C. Arnold Spek   +2 more
doaj   +1 more source

Increase in the Resistance of Plasmin to the Inactivation by α2-Plasmin Inhibitor on Incubation

Analytical Sciences, 1994
Plasmin was found to acquire resistance to the inhibition by α2-plasmin inhibitor (α2PI) on incubation at 37°C in 50% glycerin whereas its amidase activity was preserved. This resistance is ascribable to the reduction of the affinity of plasmin to α2PI, since the ability of plasmin to form the complex with α2PI was proved to decrease on incubation. The
SHIMOKAWA, Mari, KINOSHITA, Toshio
openaire   +2 more sources

Rare Bleeding Disorders and Bleeding Disorder of Unknown Cause: Current Understanding and Recent Developments

Haemophilia, EarlyView.
ABSTRACT Rare bleeding disorders (RBDs) represent a diverse group of inherited conditions involving coagulation factors or platelets. These conditions, such as Glanzmann thrombasthenia (GT) or severe coagulation factor deficiencies, are uncommon. In contrast, bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion without an identifiable ...
Alessandro Casini, Robert Klamroth, Bauke Haisma, Dino Mehic, Saskia E. M. Schols   +4 more
wiley   +1 more source

Tranexamic Acid Improves Memory and Learning Abilities in Aging Mice

Journal of Experimental Pharmacology, 2020
Keiichi Hiramoto,1 Yurika Yamate,1 Kazunari Matsuda,2 Daijiro Sugiyama,2 Yasutaka Iizuka2 1Department of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie 513-8670, Japan; 2R&D Department, Daiichi Sankyo Healthcare Co., LTD ...
Hiramoto K, Yamate Y, Matsuda K, Sugiyama D, Iizuka Y   +4 more
doaj  

Activation of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System in Periodontitis: A Case–Control Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Introduction The plasminogen activating (PA) system has a multitude of functions such as wound healing, proteolytic activity, collagen degradation and cell growth, and the role of the urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR) system has been studied in many disease states.
Ahmed Khudhur, Christopher Dowson, Susan M. Bissett, Rachel van de Merwe, John J. Taylor, Philip M. Preshaw, Katrin M. Jaedicke   +6 more
wiley   +1 more source