Results 71 to 80 of about 38,888 (195)

Thrombosis and Thrombolysis: Emphasis on Hemophilia and Effect of Clot Dissolution with Plasmin

, 2006
The purpose of this research was to understand the mechanisms in which blood clots form and are degraded. The research studies examined the role of an endogenous protease, plasmin, which is found in all vertebrates, and the optimal doses of plasmin ...
Landskroner, Kyle Alan
core  

Different Assessment of Plasmin with Different Substrates

, 2018
SummaryThe alteration of human and porcine plasmin and the influence of EACA and AMCHA on their activity were investigated. Solutions of both plasmins undergo storage induced alteration, which is best recorded by Chromozym PL, whereas the other ...
Bondeli, Ch, Lämmle, B, Duckert, F, Hänni, L   +3 more
core   +1 more source

A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants [PDF]

, 2018
In experimental assays of angiogenesis in three-dimensional fibrin matrices, a temporary scaffold formed during wound healing, the type and composition of fibrin impacts the level of sprouting. More sprouts form on high molecular weight (HMW) than on low
Koolwijk, P. (Pieter), Merks, R.M.H., M. H. Merks, Roeland, Sonja E M Boas, Goumans, M.-J. (Marie-José), Carvalho, João, Weijers, E.M., Roeland M. H. Merks (53978), Carvalho, J., Boas, S.E.M. (Sonja), Merks, Roeland M. H., Goumans, Marie-José, Marie-José Goumans (516094), Boas, S.E.M., Merks, Roeland M H, Merks, Roeland, Broek, M. van den, Ester M Weijers, Merks, R.M.H. (Roeland), Weijers, E.M. (Ester), Goumans, M.J., Joao Carvalho (5487974), Boas, Sonja, Weijers, Ester, Carvalhol, J., Sonja E. M. Boas (5487977), Carvalho, J. (Joao), M. Weijers, Ester, Marie-José Goumans, Roeland M H Merks, Koolwijk, P., Pieter Koolwijk (284312), Boas, Sonja E. M., Pieter Koolwijk, van den Broek, Marloes, Ester M. Weijers (755095), Goumans, M.-J., Marloes van den Broek (5487980), Marloes van den Broek, van den Broek, M. (Marloes), Joao Carvalho, Koolwijk, Pieter, Weijers, Ester M, E. M. Boas, Sonja, Boas, Sonja E M, Weijers, Ester M.   +45 more
core   +1 more source

Urinary pro-thrombotic, anti-thrombotic, and fibrinolytic molecules as biomarkers of lupus nephritis

Arthritis Research & Therapy, 2019
Objective This study evaluates the utility of urinary pro-thrombotic molecules such as tissue factor (TF), anti-thrombotic molecules such as tissue factor pathway inhibitor (TFPI), and fibrinolytic molecules such as plasmin and d-dimer as biomarkers of ...
Ling Qin, Samantha Stanley, Huihua Ding, Ting Zhang, Van Thi Thanh Truong, Teja Celhar, Anna-Marie Fairhurst, Claudia Pedroza, Michelle Petri, Ramesh Saxena, Chandra Mohan   +10 more
doaj   +1 more source

Thrombotic Microangiopathy‐Like Phenotype in Patients With Infection‐Associated Disseminated Intravascular Coagulation Treated With Thrombomodulin Alfa

European Journal of Haematology, EarlyView.
ABSTRACT Despite disseminated intravascular coagulation (DIC) and thrombotic microangiopathy (TMA) sharing features of thrombocytopenia, organ dysfunction, and bleeding, the relationship between these two conditions remains unclear. We therefore conducted a post hoc analysis of post‐marketing surveillance data from Japan to evaluate the clinical ...
Naoki Takezako, Fumiyo Komatsu, Goichi Honda, Noriaki Kawano, Toshimasa Uchiyama, Kazuo Kawasugi, Seiji Madoiwa, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Kohji Okamoto, Hideo Wada   +11 more
wiley   +1 more source

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, EarlyView.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Structural and Functional Studies of Plasmin Inhibitors

, 2019
Human plasmin is a plasma serine protease that plays key roles in fibrinolysis, wound healing and cell migration. Accordingly, anti-fibrinolytics targeting plasmin have been widely used for treating life-threatening bleeding during surgeries or in trauma.
GUOJIE WU (6209324)
core   +1 more source

Rare Bleeding Disorders and Bleeding Disorder of Unknown Cause: Current Understanding and Recent Developments

Haemophilia, EarlyView.
ABSTRACT Rare bleeding disorders (RBDs) represent a diverse group of inherited conditions involving coagulation factors or platelets. These conditions, such as Glanzmann thrombasthenia (GT) or severe coagulation factor deficiencies, are uncommon. In contrast, bleeding disorder of unknown cause (BDUC) is a diagnosis of exclusion without an identifiable ...
Alessandro Casini, Robert Klamroth, Bauke Haisma, Dino Mehic, Saskia E. M. Schols   +4 more
wiley   +1 more source

Activation of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System in Periodontitis: A Case–Control Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Introduction The plasminogen activating (PA) system has a multitude of functions such as wound healing, proteolytic activity, collagen degradation and cell growth, and the role of the urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR) system has been studied in many disease states.
Ahmed Khudhur, Christopher Dowson, Susan M. Bissett, Rachel van de Merwe, John J. Taylor, Philip M. Preshaw, Katrin M. Jaedicke   +6 more
wiley   +1 more source

Ciliary process disruption after plasmin treatment.

, 2014
Ciliary process disruption after intravitreal injections of plasmin. Viewed from the back of the eye, partial ciliary body disruption was noted in the eyes treated with plasmin and SF6 (plasmin+SF6 group) or plasmin alone (plasmin group) (black arrows ...
Chi-Chun Lai (287544), Kwan-Jen Chen (661065), Tun-Lu Chen (661066), Lien-Min Li (661068), Chi-Hsien Liu (661064), Nan-Kai Wang (287541), Wei-Chi Wu (287560), Pei-Ju Liao (661067), Yih-Shiou Hwang (428940)   +8 more
core   +1 more source