Results 71 to 80 of about 36,053 (249)

A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants [PDF]

, 2018
In experimental assays of angiogenesis in three-dimensional fibrin matrices, a temporary scaffold formed during wound healing, the type and composition of fibrin impacts the level of sprouting. More sprouts form on high molecular weight (HMW) than on low
Koolwijk, P. (Pieter), Merks, R.M.H., M. H. Merks, Roeland, Sonja E M Boas, Goumans, M.-J. (Marie-José), Carvalho, João, Weijers, E.M., Roeland M. H. Merks (53978), Carvalho, J., Boas, S.E.M. (Sonja), Merks, Roeland M. H., Goumans, Marie-José, Marie-José Goumans (516094), Boas, S.E.M., Merks, Roeland M H, Merks, Roeland, Broek, M. van den, Ester M Weijers, Merks, R.M.H. (Roeland), Weijers, E.M. (Ester), Goumans, M.J., Joao Carvalho (5487974), Boas, Sonja, Weijers, Ester, Carvalhol, J., Sonja E. M. Boas (5487977), Carvalho, J. (Joao), M. Weijers, Ester, Marie-José Goumans, Roeland M H Merks, Koolwijk, P., Pieter Koolwijk (284312), Boas, Sonja E. M., Pieter Koolwijk, van den Broek, Marloes, Ester M. Weijers (755095), Goumans, M.-J., Marloes van den Broek (5487980), Marloes van den Broek, van den Broek, M. (Marloes), Joao Carvalho, Koolwijk, Pieter, Weijers, Ester M, E. M. Boas, Sonja, Boas, Sonja E M, Weijers, Ester M.   +45 more
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Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

British Journal of Pharmacology, EarlyView.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers   +3 more
wiley   +1 more source

Using antifibrinolytics to tackle neuroinflammation

Neural Regeneration Research, 2020
Plasmin is generally known as a promotor of inflammation. Recent advancement suggests that it has a complex role as immunity modulator. Pharmacological inhibition of plasmin production and activity has been proven to improve neurological outcomes in ...
Stanimir Atsev, Nikola Tomov
doaj   +1 more source

Interaction between pregnancy zone protein and plasmin

, 1988
Pregnancy zone protein (PZP, α2-PAG, SP3) was found to bind to plasmin in crossed affino-immunoelectrophoresis using sodium caseinate in the first dimension gel.
Poulsen, O. M., Hau, J.
core   +1 more source

Garadacimab for the long‐term prophylaxis of hereditary angioedema

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Emel Aygören‐Pürsün, Regina Treudler, Petra Staubach, Inmaculada Martinez Saguer, Thomas Linhoff, Markus Magerl   +5 more
wiley   +1 more source

Structural and Functional Studies of Plasmin Inhibitors

, 2019
Human plasmin is a plasma serine protease that plays key roles in fibrinolysis, wound healing and cell migration. Accordingly, anti-fibrinolytics targeting plasmin have been widely used for treating life-threatening bleeding during surgeries or in trauma.
GUOJIE WU (6209324)
core   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Plasminogen and plasmin in Alzheimer's disease

, 2010
In Alzheimer's disease, abnormal accumulation of Aβ leads to neuronal death and impaired Aβ degradation may play an important role in this accumulation. Plasmin is the key active protease in the plasminogen system and is capable of cleaving Aβ.
Barker, Rachel, Seth Love, Love, Seth, Patrick G. Kehoe, Rachel Barker, Kehoe, Patrick G   +5 more
core   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Thrombosis and Thrombolysis: Emphasis on Hemophilia and Effect of Clot Dissolution with Plasmin

, 2006
The purpose of this research was to understand the mechanisms in which blood clots form and are degraded. The research studies examined the role of an endogenous protease, plasmin, which is found in all vertebrates, and the optimal doses of plasmin ...
Landskroner, Kyle Alan
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