Results 141 to 150 of about 241,553 (351)

Long‐term remission in gout: Challenges and future opportunities

Rheumatology &Autoimmunity, EarlyView.
Prolonged hyperuricemia is a major risk factor for gout, which is now regarded as a curable disease. Awareness of the various factors that can trigger gout flares is essential for their prevention. An important determinant of treatment decisions and long‐term follow‐up is the quality of the clinician–patient relationship. The “treat‐to‐target” approach
Patapong Towiwat, Zhanguo Li
wiley   +1 more source

The Activation of Human Plasminogen

, 1958
Norma Alkjærsig, Anthony P. Fletcher, Sol Sherry   +2 more
openalex   +1 more source

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

Chinese Guidelines for Diagnosis and Treatment of Chronic Rhinosinusitis (2024)

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Chronic rhinosinusitis (CRS), a complex inflammatory disease with heterogeneous pathogenesis, demands evolving evidence‐based strategies. Since the 2018 Chinese guidelines and EPOS2020, international advances in CRS immunopathology and biologics have revolutionized therapeutic approaches, particularly through phenotype–endotype classification ...
Subspecialty Group of Rhinology, Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery, Subspecialty Group of Rhinology, Society of Otorhinolaryngology Head and Neck Surgery, Chinese Medical Association   +4 more
wiley   +1 more source

Epigenetic Clock Analysis of Sex Chromosome Aneuploidies

Aging Cell, EarlyView.
Next‐generation epigenetic clocks indicate lower age acceleration and slower pace of aging in 47,XXY than 46,XX, 46,XY, and 47,XYY. A first‐generation clock (Skin & Blood) indicates higher age acceleration in 47,XXY and 47,XYY than 46,XY, while higher naïve CD8+ T in 47,XXY than both 46,XY and 46,XX suggests reduced immunosenescence.
Joshua Zhang, Jordan Teoli, Benjamin Rey, Cristina Vieira, Jean‐François Lemaitre, Ingrid Plotton, Gabriel A. B. Marais, Steve Horvath   +7 more
wiley   +1 more source

Plasminogen deficiency reduces disease severity and immune responses in enterovirus A71-infected mice

Microbiology Spectrum
Enterovirus A71 (EV-A71) is a causative agent of hand, foot, and mouth diseases. EV-A71 infections may result in severe neurological complications in children. Although several receptors or attachment molecules for EV-A71 have been identified, EV-A71 can
Zheng-Xun Li, Ya-Fang Wang, Li-Ting Chiang, Li-Jin Hsu, Shih-Min Wang, Jen-Ren Wang, Hua-Lin Wu, Shun-Hua Chen, Chuan-Fa Chang   +8 more
doaj   +1 more source

Studies on Plasminogen Activators. II. A Method for the Separation of Purified Urokinase from Small Samples of Urine. [PDF]

, 1966
Ulla Hamberg, Maija-Liisa Savolainen, Lars Pilström, Egil Vestersjø, Oddvar Stokke, E. Bunnenberg, Carl Djerassi, Ruth Records   +7 more
openalex   +1 more source

Baricitinib Augments Lonafarnib Therapy to Preserve Colonic Homeostasis and Microbial Balance in a Mouse Model of Progeria

Aging Cell, EarlyView.
Combined baricitinib and lonafarnib treatment improved colonic pathology in LmnaG609G/G609G progeria mice by reducing progerin, maintaining epithelial regeneration, mitigating inflammation and senescence, and preserving microbiome composition. ABSTRACT Hutchinson‐Gilford Progeria Syndrome (HGPS) is a fatal genetic disorder caused by progerin, a mutant ...
Moritz Schroll, Yacine Amar, Peter Krüger, Klaus Neuhaus, Karima Djabali   +4 more
wiley   +1 more source

Molecular Weight Studies on Human Plasminogen and Plasmin at the Microgram Level

, 1969
Grant H. Barlow, Louis Summaria, Kenneth C. Robbins   +2 more
openalex   +1 more source

Abnormal Plasminogen-Plasmin System Activity (Fibrinolysis) in Patients with Hepatic Cirrhosis: Its Cause and Consequences* [PDF]

, 1964
Anthony P. Fletcher, Oliver Biederman, Don Moore, Norma Alkjærsig, Sol Sherry   +4 more
openalex   +1 more source