Results 151 to 160 of about 151,729 (305)

Brain plasminogen system

, 2010
Endothelial cells, glial and neuronal cells, representing the principal sources of plasminogen activator (tPA and uPA), are in close interaction in the neurovascular unit. Formation of plasmin at the surface of endothelial cells and neurons has important
Mezzapesa A, Mata S, Pepe G, Doeuvre L, Orset C, Chimienti G, Angles-Cano E.   +6 more
core  

Streptolysin O accelerates the conversion of plasminogen to plasmin

Group A Streptococcus (GAS) is a human-specific bacterial pathogen that can exploit the plasminogen-plasmin fibrinolysis system to dismantle blood clots and facilitate its spread and survival within the human host.
Ekström, Simon, Hjortswang, Elisabeth, Khakzad, Hamed, Malmström, Lars, Tang, Di, Happonen, Lotta, Malmström, Johan, Malmström, Lars,, Hjortswang, Elisabeth,, Happonen, Lotta,, Malmström, Johan,, Khakzad, Hamed,, Ekström, Simon,, Lund University., Tang, Di,   +14 more
core   +1 more source

Complement–Eosinophil Crosstalk Links Complement Activation to Fibrin Deposition in Eosinophilic Chronic Rhinosinusitis

Allergy, EarlyView.
Ryo Hasegawa, Shigeharu Ueki, Misaki Arima, Shohei Nishiyama, Keinosuke Hizuka, Kohei Tatsumi, Ayako Sawai, Anna Shimizu, Yuki Sonoda, Eiichi Kato, Masanori Kidoguchi, Masafumi Sakashita, Yohei Sato, Atsushi Kato, Bruce K. Tan, Robert C. Kern, Robert P. Schleimer, Shigeharu Fujieda, Yoshimasa Imoto   +18 more
wiley   +1 more source

Population Pharmacokinetics of Plasma‑Derived Factor X Using Clotting and Chromogenic Assays: A WAPPS‑Hemo Model

Haemophilia, EarlyView.
ABSTRACT Background Hereditary factor X (FX) deficiency is a rare autosomal recessive bleeding disorder for which individualized pharmacokinetic (PK) assessment can support optimized prophylactic management. The WAPPS‐Hemo platform enables population pharmacokinetic (PopPK) individualized PK predictions based on sparse sampling.
Dagmar M. Hajducek, Pierre Chelle, Manuela Scarpellini, Andrea Edginton, Alfonso Iorio   +4 more
wiley   +1 more source

Venous thromboembolism is not associated with plasmin(ogen): reevaluating plasmin and mechanisms that degrade fibrin. [PDF]

Blood Adv
Sang Y, Shapiro AD, Wolberg AS.
europepmc   +1 more source

Activation of the Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor System in Periodontitis: A Case–Control Study

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Introduction The plasminogen activating (PA) system has a multitude of functions such as wound healing, proteolytic activity, collagen degradation and cell growth, and the role of the urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR) system has been studied in many disease states.
Ahmed Khudhur, Christopher Dowson, Susan M. Bissett, Rachel van de Merwe, John J. Taylor, Philip M. Preshaw, Katrin M. Jaedicke   +6 more
wiley   +1 more source

Acute Ischaemic Stroke: Therapeutic Targets and Key Modulators of the Fibrinolytic System and Clot Formation. [PDF]

Transl Stroke Res
Swarup O, Balabanski AH, Cloud GC, Medcalf RL.   +3 more
europepmc   +1 more source

The Biological Basis of the Merlin CP‐GEP Assay: Integrin Signaling and Early Metastatic Competence in Cutaneous Melanoma

International Journal of Dermatology, EarlyView.
Merlin CP‐GEP integrates mechanistic insights into a clinically actionable assay to predict SLN metastasis risk and inform personalized management of cutaneous melanoma. ABSTRACT The recent inclusion of the Merlin clinicopathologic–gene expression profile (CP‐GEP) assay in the National Comprehensive Cancer Network (NCCN) Melanoma Guidelines represents ...
Frank Z. Jing, Alexander Meves
wiley   +1 more source

A rapid and simple method for the separation of four molecular forms of human plasminogen

, 1989
At least four molecular forms of plasminogen are known. Two of those forms have glutamic acid at their amino-terminal end, and are designated as glu-plasminogen.
Nieuwenhuizen, W., Traas, D.W.
core  

How I Investigate Bleeding Disorders of Unknown Cause: Current Diagnostic Pathways and Gaps in Laboratory Investigation

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Bleeding disorder of unknown cause (BDUC) constitutes the largest group of patients presenting with a mild‐to‐moderate bleeding tendency in tertiary care settings. Their clinical bleeding phenotype is characterized by mucocutaneous bleeding, as well as bleeding following surgical challenges or childbirth, and is associated with impaired health‐
Dino Mehic, Faris Karaselimovic, Tim Dreier, Johanna Gebhart   +3 more
wiley   +1 more source