Results 171 to 180 of about 151,729 (305)

Plasminogen-induced IL-1beta and TNF-alpha production in microglia is regulated by reactive oxygen species.

, 2003
Microglia, major immune effector cells in the central nervous system, become activated during brain injury. In this study we showed that the blood component plasminogen/plasmin activates microglia.
Joe, E, Min, KJ, Jou, I
core  

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Tenecteplase and other TNK formulations lose PAI-1 resistance in their 2-chain form: comparison with alteplase. [PDF]

Blood Adv
Liu Z, Tippett I, McCutcheon F, Keragala CB, McDonald A, Sharma G, Lin L, Xiong Y, Wang Y, Lam T, Cloud GC, Campbell BCV, Parsons MW, Medcalf RL.   +13 more
europepmc   +1 more source

Oral Soft Tissue Biopsy in Patients Receiving Direct Oral Anticoagulants: A Prospective Cohort Study on Bleeding Outcomes

Oral Diseases, EarlyView.
ABSTRACT Background Direct oral anticoagulants (DOACs) are the first‐line therapy for stroke prevention in non‐valvular atrial fibrillation and venous thromboembolism. While evidence supports their continuation during routine dental procedures such as tooth extractions, data on oral soft tissue biopsies remain limited.
Rossana Izzetti, Chiara Cinquini, Antonio Barone, Marco Nisi   +3 more
wiley   +1 more source

Plain language summary: How safe and effective is long-term treatment with intravenous plasminogen concentrate for people with type 1 plasminogen deficiency? [PDF]

Ther Adv Hematol
Shapiro AD, McDaniel H, Decker RW, Nakar C, Lorber J, Thukral N, Parker JM, Thibaudeau K.   +7 more
europepmc   +1 more source

Quantitative Proteomics of Plasma-Derived Extracellular Vesicles Reveals a Plasminogen-Centered Protein Network in Transthyretin Cardiac Amyloidosis. [PDF]

JACC Adv
Zaroui A, Habert D, Vallée B, Kharoubi M, Fellahi S, Vingert B, Seve M, Cascone I, Audard V, Itti E, Abroud H, Galat A, Damy T, Bourgoin-Voillard S, Molinier-Frenkel V.   +14 more
europepmc   +1 more source

Novel Roles of Urokinase- and Tissue-Type Plasminogen Activators in Substance Use Disorders: A Narrative Review of Molecular Mechanisms and Translational Perspectives. [PDF]

Int J Mol Sci
Bahi A, Steele S.
europepmc   +1 more source

Periodontitis and rheumatoid arthritis—Global efforts to untangle two complex diseases

Periodontology 2000, EarlyView.
Abstract Understanding the impact of oral health on rheumatoid arthritis (RA) will inform how best to manage patients with both periodontitis and RA. This review seeks to provide an update on interventional and mechanistic investigations, including a brief summary of European Research programs investigating the link between periodontitis and RA. Recent
Isabel Lopez‐Oliva, Jennifer Malcolm, Shauna Culshaw   +2 more
wiley   +1 more source

Etiology, pathogenesis and treatment of peri‐implantitis: A European perspective

Periodontology 2000, EarlyView.
Abstract Peri‐implantitis is a plaque‐associated pathological condition occurring in tissues around dental implants. It is characterized by inflammation in the peri‐implant mucosa and progressive loss of supporting bone. Over the last 30 years, peri‐implantitis has become a major disease burden in dentistry.
Tord Berglundh, Andrea Mombelli, Frank Schwarz, Jan Derks   +3 more
wiley   +1 more source

A grading system of dynamic fibrinolysis resistance in sepsis associates with ICU outcomes. [PDF]

Am J Respir Crit Care Med
Coupland LA, Frost SA, Lin J, Pham N, Self M, Crispin PJ, Rabbolini DJ, Keragala CB, Medcalf RL, Aneman A.   +9 more
europepmc   +1 more source