Results 11 to 20 of about 315,782 (393)

A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?

open access: yesInternational Journal of Molecular Sciences, 2021
Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of plasminogen activators (PAs) and is therefore an important inhibitor of the plasminogen/plasmin system.
M. Sillen, P. Declerck
semanticscholar   +1 more source

Histone 2B Facilitates Plasminogen-Enhanced Endothelial Migration through Protease-Activated Receptor 1 (PAR1) and Protease-Activated Receptor 2 (PAR2)

open access: yesBiomolecules, 2022
Plasminogen and its multiple receptors have been implicated in the responses of many different cell types. Among these receptors, histone 2B (H2B) has been shown to play a prominent role in macrophage responses.
Mitali Das   +2 more
doaj   +1 more source

Plasminogen: an enigmatic zymogen.

open access: yesBlood, 2021
Plasminogen is an abundant plasma protein that exists in various zymogenic forms. Plasmin, the proteolytically active form of plasminogen, is known for its essential role in fibrinolysis.
Charithani B. Keragala   +1 more
semanticscholar   +1 more source

DnaK Functions as a Moonlighting Protein on the Surface of Mycoplasma hyorhinis Cells

open access: yesFrontiers in Microbiology, 2022
Mycoplasma hyorhinis is a common pathogen of swine and is also associated with various human tumors. It causes systemic inflammation, typically polyserositis and polyarthritis, in some infected pigs. However, the pathogenic mechanism of M.
Yao Li   +25 more
doaj   +1 more source

Heat-Treatments Affect Protease Activities and Peptide Profiles of Ruminants' Milk

open access: yesFrontiers in Nutrition, 2021
Proteases present in milk are heat-sensitive, and their activities increase or decrease depending on the intensity of the thermal treatment applied. The thermal effects on the protease activity are well-known for bovine milk but poorly understood for ...
Juliana A. S. Leite   +14 more
doaj   +1 more source

The Plasminogen–Activator Plasmin System in Physiological and Pathophysiological Angiogenesis

open access: yesInternational Journal of Molecular Sciences, 2021
Angiogenesis is a process associated with the migration and proliferation of endothelial cells (EC) to form new blood vessels. It is involved in various physiological and pathophysiological conditions and is controlled by a wide range of proangiogenic ...
A. Ismail, B. Shaker, K. Bajou
semanticscholar   +1 more source

Plasminogen deficiency [PDF]

open access: yesHaemophilia, 2008
Summary.  Plasminogen deficiency has emerged as a well‐recognized disorder in which reduced levels of plasminogen lead to the development of pseudo membranes on mucosal surfaces, with subsequent end‐organ damage of the affected tissue. Ligneous conjunctivitis is the most recognizable, well‐documented, and common presentation of the clinical syndromes ...
R, Mehta, A D, Shapiro
openaire   +2 more sources

Plasmin and Plasminogen System in the Tumor Microenvironment: Implications for Cancer Diagnosis, Prognosis, and Therapy

open access: yesCancers, 2021
Simple Summary In this review, we present a detailed discussion of how the plasminogen-activation system is utilized by tumor cells in their unrelenting attack on the tissues surrounding them.
Alamelu G. Bharadwaj   +3 more
semanticscholar   +1 more source

Plasminogen-Loaded Fibrin Scaffold as Drug Delivery System for Wound Healing Applications

open access: yesPharmaceutics, 2022
Plasminogen is a protein involved in intravascular and extravascular fibrinolysis, as well as in wound healing, cell migration, tissue formation and angiogenesis.
Tamer Al Kayal   +5 more
doaj   +1 more source

Biopharmaceutical Assessment of Mesh Aerosolised Plasminogen, a Step towards ARDS Treatment

open access: yesPharmaceutics, 2023
Acute respiratory distress syndrome (ARDS) is a severe complication of lung injuries, commonly associated with bacterial, fungal and viral infections, including SARS-CoV-2 viral infections.
Lucia Vizzoni   +12 more
doaj   +1 more source

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