Results 11 to 20 of about 201,835 (360)
International Journal of Molecular Sciences, 2021 Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of plasminogen activators (PAs) and is therefore an important inhibitor of the plasminogen/plasmin system.
M. Sillen, P. Declerck
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Plasminogen: an enigmatic zymogen.
Blood, 2021 Plasminogen is an abundant plasma protein that exists in various zymogenic forms. Plasmin, the proteolytically active form of plasminogen, is known for its essential role in fibrinolysis.
Charithani B. Keragala +1 more
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The Plasminogen–Activator Plasmin System in Physiological and Pathophysiological Angiogenesis
International Journal of Molecular Sciences, 2021 Angiogenesis is a process associated with the migration and proliferation of endothelial cells (EC) to form new blood vessels. It is involved in various physiological and pathophysiological conditions and is controlled by a wide range of proangiogenic ...
A. Ismail, B. Shaker, K. Bajou
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Cancers, 2021 Simple Summary In this review, we present a detailed discussion of how the plasminogen-activation system is utilized by tumor cells in their unrelenting attack on the tissues surrounding them.
Alamelu G. Bharadwaj +3 more
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Haemophilia, 2008 Summary. Plasminogen deficiency has emerged as a well‐recognized disorder in which reduced levels of plasminogen lead to the development of pseudo membranes on mucosal surfaces, with subsequent end‐organ damage of the affected tissue. Ligneous conjunctivitis is the most recognizable, well‐documented, and common presentation of the clinical syndromes ...
R, Mehta, A D, Shapiro
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All tangled up: interactions of the fibrinolytic and innate immune systems
Frontiers in Medicine, 2023 The hemostatic and innate immune system are intertwined processes. Inflammation within the vasculature promotes thrombus development, whilst fibrin forms part of the innate immune response to trap invading pathogens.
Claire S. Whyte
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MHJ_0125 is an M42 glutamyl aminopeptidase that moonlights as a multifunctional adhesin on the surface of Mycoplasma hyopneumoniae [PDF]
Open Biology, 2013 Bacterial aminopeptidases play important roles in pathogenesis by providing a source of amino acids from exogenous proteins, destroying host immunological effector peptides and executing posttranslational modification of bacterial and host proteins.
Mark W. Robinson +12 more
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Frontiers in Microbiology, 2020 Dispersin is a 10.2 kDa-immunogenic protein secreted by enteroaggregative Escherichia coli (EAEC). In the prototypical EAEC strain 042, dispersin is non-covalently bound to the outer membrane, assisting dispersion across the intestinal mucosa by ...
Claudia T. P. Moraes +11 more
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Plasminogen–receptor KT: plasminogen activation and beyond [PDF]
Journal of Thrombosis and Haemostasis, 2017 The cell surface orchestrates plasminogen activation through the concomitant binding of plasminogen and plasminogen activators to specific receptors. In this issue, Miles and colleagues describe their detailed phenotypic characterization of mice deficient in Plg-RKT, a key plasminogen receptor expressed in numerous tissues, but highly expressed by ...
M J, Flick, T H, Bugge
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A critical role for plasminogen in inflammation
Journal of Experimental Medicine, 2020 Plasminogen, primarily a blood protein involved in fibrinolysis, also participates in inflammatory processes throughout the body. Baker and Strickland summarize the role of plasminogen and its activator system in regulating inflammation in health and ...
S. K. Baker, S. Strickland
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