Results 11 to 20 of about 190,587 (365)
Cancers, 2021 Simple Summary In this review, we present a detailed discussion of how the plasminogen-activation system is utilized by tumor cells in their unrelenting attack on the tissues surrounding them.
Alamelu G. Bharadwaj +3 more
semanticscholar +1 more source
MHJ_0125 is an M42 glutamyl aminopeptidase that moonlights as a multifunctional adhesin on the surface of Mycoplasma hyopneumoniae [PDF]
Open Biology, 2013 Bacterial aminopeptidases play important roles in pathogenesis by providing a source of amino acids from exogenous proteins, destroying host immunological effector peptides and executing posttranslational modification of bacterial and host proteins.
Mark W. Robinson +12 more
doaj +1 more source
Disease Models & Mechanisms, 2021 Susceptibility to doxorubicin-induced nephropathy (DIN), a toxic model for the induction of proteinuria in mice, is related to the single-nucleotide polymorphism (SNP) C6418T of the Prkdc gene encoding for the DNA-repair enzyme DNA-PKcs.
Bernhard N. Bohnert +17 more
doaj +1 more source
The Plasminogen–Activator Plasmin System in Physiological and Pathophysiological Angiogenesis
International Journal of Molecular Sciences, 2021 Angiogenesis is a process associated with the migration and proliferation of endothelial cells (EC) to form new blood vessels. It is involved in various physiological and pathophysiological conditions and is controlled by a wide range of proangiogenic ...
A. Ismail, B. Shaker, K. Bajou
semanticscholar +1 more source
Tissue plasminogen activator for acute ischemic stroke.
New England Journal of Medicine, 1996 BACKGROUND Thrombolytic therapy for acute ischemic stroke has been approached cautiously because there were high rates of intracerebral hemorrhage in early clinical trials.
Koroshetz Wj
semanticscholar +2 more sources
All tangled up: interactions of the fibrinolytic and innate immune systems
Frontiers in Medicine, 2023 The hemostatic and innate immune system are intertwined processes. Inflammation within the vasculature promotes thrombus development, whilst fibrin forms part of the innate immune response to trap invading pathogens.
Claire S. Whyte
doaj +1 more source
Interaction of plasminogen and fibrin in plasminogen activation. [PDF]
Journal of Biological Chemistry, 1990 Glu1-, Lys77-, miniplasminogens, kringle 1-3, kringle 1-5A, and kringle 1-5R were able to bind with fibrin, while microplasminogen and kringle 4 did not bind significantly. Kringle 1-5A, but not kringle 1-3, effectively inhibited the binding of Glu1-, Lys77-, and miniplasminogens with fibrin.
Bi-Ing Chang +6 more
openaire +2 more sources
Plasminogen Receptors and Fibrinolysis [PDF]
International Journal of Molecular Sciences, 2021 The ability of cells to promote plasminogen activation on their surfaces is now well recognized, and several distinct cell surface proteins have been demonstrated to function as plasminogen receptors. Here, we review studies demonstrating that plasminogen bound to cells, in addition to plasminogen directly bound to fibrin, plays a major role in ...
Lindsey A. Miles +5 more
openaire +4 more sources
Biomedical Papers, 2020 Aim: We assessed various ways of tranexamic acid (TXA) administration on the fibrinolytic system. Blood loss, transfusions, drainage and haematoma were secondary outcomes.
Jiri Lostak +4 more
doaj +1 more source
Microorganisms, 2023 The main causative agent of pneumonia, Streptococcus pneumoniae, is also responsible for invasive diseases. S. pneumoniae recruits human plasminogen for the invasion and colonization of host tissues. We previously discovered that S.
Satoru Hirayama +4 more
doaj +1 more source