Results 211 to 220 of about 101,655 (293)

Characterization of Muscle Tissue Cell Diversity and Clinical Implications in Idiopathic Inflammatory Myopathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background Idiopathic inflammatory myopathies (IIMs) exhibit diverse cellular microenvironments in muscle tissues, yet the full spectrum of cell populations and changes remains unclear. This study aimed to characterize cellular heterogeneity, explore cell–cell interactions and assess the prognostic value of cell subtype abundances across IIM ...
Honglin Zhu, Yizhi Xiao, Shasha Xie, Qiming Meng, Ting Ding, Ting Huang, Di Liu, Sijia Liu, Xiaoli Zhang, Huali Zhang, Hui Luo   +10 more
wiley   +1 more source

Hydrophobic residues in the D‐domain of a plasminogen‐binding M‐protein modulate α‐helicity, oligomerization, and surface anchoring in Streptococcus pyogenes

Protein Science, Volume 34, Issue 10, October 2025.
Abstract Human plasminogen (hPg) binding M‐protein (PAM) is a major virulence determinant of Group A Streptococcus (GAS). PAM contains irregularly spaced heptad repeats, particularly within its C‐ and D‐domains. Our recent cryo‐EM structure of PAM from GAS strain AP53 (PAMAP53) revealed that these repeats do not favor coiled‐coil formation, but instead
Olawole Ayinuola, Yetunde A. Ayinuola, Zhong Liang, Francis J. Castellino   +3 more
wiley   +1 more source

Micro‐Embolic Events and Their Clearing in the Brain. A Narrative Review

Acta Physiologica, Volume 241, Issue 10, October 2025.
ABSTRACT Background The cerebral circulation is continuously challenged by intravascular micrometer‐sized particles that become trapped microvascular‐emboli. These particles may include micro‐thrombi, stiffened erythrocytes, and leukocytes, while also fat particles, air, and microplastics may cause microvascular embolism. Review Scope In this narrative
Kevin Mol, Inge A. Mulder, Ed van Bavel
wiley   +1 more source

Plasminogen receptors and their role in the pathogenesis of inflammatory, autoimmune and malignant disease

Journal of Thrombosis and Haemostasis, 2013
A. Godier, B. Hunt, B. Hunt
semanticscholar   +1 more source

Decreases in circulating ANGPTL3/8 concentrations following retatrutide treatment parallel reductions in serum lipids

Diabetes, Obesity and Metabolism, Volume 27, Issue 10, Page 5985-5995, October 2025.
Abstract Aims The aim of this study was to determine if retatrutide, a triple agonist of glucose‐dependent insulinotropic polypeptide (GIP) receptor, glucagon‐like peptide 1 (GLP‐1) receptor and glucagon (GCG) receptor, may lower serum triglyceride (TG) and low‐density lipoprotein cholesterol (LDL‐C) levels in part by decreasing circulating ...
Yi Wen, Deven Lemen, Yanzhu Lin, Yan Q. Chen, Ajit Regmi, William C. Roell, Melissa K. Thomas, Mark L. Hartman, Tamer Coskun, Zvonko Milicevic, Axel Haupt, Giacomo Ruotolo, Robert J. Konrad   +12 more
wiley   +1 more source

The mechanism of activation of rabbit plasminogen by urokinase.

, 1975
JM Sodetz, FJ Castellino
openalex   +1 more source

Plasminogen Receptors: The First Quarter Century

Seminars in Thrombosis and Hemostasis, 2013
L. Miles, R. Parmer
semanticscholar   +1 more source

Contraception in Myeloproliferative Neoplasms: A Pharmacological Review

European Journal of Haematology, Volume 115, Issue 4, Page 344-348, October 2025.
ABSTRACT Myeloproliferative neoplasms (MPNs) are chronic hematologic disorders characterized by clonal proliferation of myeloid lineage cells, commonly driven by JAK2 mutations, and associated with significant thrombotic and hemorrhagic complications.
Awni Alshurafa, Maria Benkhadra, Anas M. Babiker, Wafa M. Mohammed, Mohamed A. Yassin   +4 more
wiley   +1 more source

The Primary Structure of Human Plasminogen

, 1972
Kenneth C. Robbins, Priscilla Bernabe, Leonida Arzadon, Louis Summaria   +3 more
openalex   +1 more source

Development and Validation of a Liquid Chromatography High‐Resolution Mass Spectrometry Method for Blood Desmopressin Quantification and Its Application in Hemophilia A Patients

Rapid Communications in Mass Spectrometry, Volume 39, Issue 18, 30 September 2025.
ABSTRACT Desmopressin (DDAVP), which indirectly increases Coagulation Factor VIII concentrations in the blood, is a common treatment for bleeding disorders such as von Willebrand disease or hemophilia A. However, DDAVP exhibits significant variability in response due to interindividual differences in pharmacokinetics.
Sophie Hodin, Jean Escal, Catherine Feliu, Adeline Pontis, Laurie Josset, Adrian Serban, Benoît Guillet, Xavier Delavenne   +7 more
wiley   +1 more source