Results 201 to 210 of about 213,256 (305)

Systemic Drivers and Molecular Mechanisms of Sarcopenia in Aetiology‐Specific End‐Stage Liver Disease

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Patients with end‐stage liver disease (ESLD) often present with sarcopenia, defined as loss of skeletal muscle mass and quality, which is associated with reduced quality of life and increased mortality. However, the molecular mechanisms driving sarcopenia in ESLD are not fully understood and there are currently no therapeutic ...
Thomas Nicholson, Sophie L. Allen, Jonathan I. Quinlan, Amritpal Dhaliwal, Michael Macleod, Joshua Price, Jon Hazeldine, Michael S. Sagmeister, Caitlin Ditchfield, Kirsty C. McGee, Felicity R. Williams, Ahmed M. Elsharkawy, Matthew J. Armstrong, Carolyn A. Greig, Janet M. Lord, Leigh Breen, Simon W. Jones   +16 more
wiley   +1 more source

Tissue-Based Multiomic Exploratory Analysis of the Urokinase Plasminogen Activator/uPAR System and Matrix Metalloproteinases in Stroma AReactive Invasion Front Areas-Positive Gastrointestinal Cancers.

Pathobiology
Reitsam NG, Grosser B, Dintner S, Grozdanov V, Sommer F, Heyer C, Schlesner M, Hardt J, Franz S, Schenkirsch G, Probst A, Löhr P, Waidhauser J, Märkl B.   +13 more
europepmc   +1 more source

Sturge-Weber Syndrome With Leptomeningeal Angiomatosis and Middle Cerebral Artery Narrowing Treated With Intravenous Tissue Plasminogen Activator (IV tPA): A Case Report. [PDF]

Cureus
Kaur G, Sardana S, Mateti NR, Debiec J, Saim M, Abdullah H, Singh R, Wright D, Cerejo R.   +8 more
europepmc   +1 more source

Deletion of a Pax1 Sex‐Associated Genomic Region Associated With Adolescent Idiopathic Scoliosis Leads to Disc Degeneration, Instability, and Vertebral Rotation in Mice

JOR SPINE, Volume 9, Issue 2, June 2026.
Overview of the effects of Pax1‐SAR deletion on gene expression, IVD degeneration, and resultant scoliotic‐like curvature between sexes. Proposed mechanism of sex‐dependent changes in gene expression in females (right) and males (left), resulting in sex‐dependent disc degeneration and scoliotic phenotypes.
Edward C. Moody, Emma M. Wade, Shuji Mizumoto, Jeremy McCallum‐Loudeac, Megan J. Wilson   +4 more
wiley   +1 more source

Inhibition of PLA2G15 Alleviates Palmitic Acid‐Induced Lysosomal Membrane Permeabilization in Human Nucleus Pulposus Cells During Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 2, June 2026.
LMP is responsible for lysosomal dysfunction in IDD. The lipid composition changes in the lysosomal membrane, mediated by PLA2G15, are the cause of LMP. The C/EBPα significantly promotes PLA2G15 expression under PA overload stress. Inhibition of PLA2G15 alleviates PA‐induced LMP by inhibiting the hydrolysis of lysosomal membrane phospholipids. ABSTRACT
Liqun Duan, Jiang Jiang, Shuangshuang Tu, Chuanfu Li, Yijun Dong, Yongjin Li, Wenzhi Zhang, Xi Chen   +7 more
wiley   +1 more source

Abnormalities of liver sinusoidal endothelial cells in primary biliary cholangitis. [PDF]

World J Exp Med
Thalassinos E, Notas G, Xidakis C, Drygiannakis I, Sfakianaki O, Tsomidis I, Kouroumalis E.   +6 more
europepmc   +1 more source

Management of neonatal massive hemorrhage: A narrative review

Transfusion, EarlyView.
Cheryl S. L. Chooi, Mary Claire Simmonds, Laura Fisher, Tara Crawford, Michael J. Stark, Scott Morris, Marcus Brecht, Fiona Taverner   +7 more
wiley   +1 more source

Effect of Anthocyanin‐Rich New Zealand Blackcurrant on Tumour Necrosis Factor‐α–Induced Plasminogen Activator Inhibitor‐1 Release in Airway Epithelial Cells: A Preliminary Study

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
Pretreatment with New Zealand blackcurrant anthocyanins nonsignificantly reduced TNF‐α–induced PAI‐1 release in bronchial epithelial cells. The small sample size may have influenced the lack of statistical significance. This study provides preliminary evidence of possible effects of NZBC anthocyanins on PAI‐1 secretion but warrants further extensive ...
Madiha Ajaz, Ayesha Zahid, Rati Jani, Lada Vugic, Indu Singh, Natalie Shilton   +5 more
wiley   +1 more source

Plasma Plasminogen Activator Inhibitor-1 as a Biomarker for Disease Activity and Pharmaco-Response Prediction in Pediatric Epilepsy: A Prospective Cohort Study. [PDF]

Neuropsychiatr Dis Treat
Xiao X, Shi XY, Feng J, Zhou XY, Wang ML, Zhang BB, Xu C, Tang JH.   +7 more
europepmc   +1 more source

Transcriptomic analysis reveals the hepatic response mechanisms of the Chinese spiny frog (Quasipaa spinosa) to Citrobacter freundii infection

Journal of the World Aquaculture Society, Volume 57, Issue 3, June 2026.
Abstract To elucidate the pathogen and host response mechanisms underlying mass mortality in Quasipaa spinosa, dominant bacteria were isolated from diseased individuals and identified as Citrobacter freundii by morphological, physiological, and biochemical characterization, 16S rRNA sequencing, and phylogenetic analysis.
Yanhong Li, Baohong Zhou, Yiran Lu, Yi Zang, Minghao Hu, Qiaochen Jin, Wenbin Fang, Shanjian Zheng   +7 more
wiley   +1 more source