Results 221 to 230 of about 101,655 (293)

Diabetes is associated with posttranslational modifications in plasminogen resulting in reduced plasmin generation and enzyme-specific activity.

Blood, 2013
R. Ajjan, T. Gamlen, K. Standeven, Salihah Mughal, K. Hess, Kerrie A. Smith, E. J. Dunn, M. M. Anwar, N. Rabbani, Paul J Thornalley, H. Philippou, P. Grant   +11 more
semanticscholar   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, Volume 19, Issue 9, Page 2537-2556, September 2025.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, Volume 19, Issue 9, Page 2491-2514, September 2025.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Lack of correlation between tumorigenicity and level of plasminogen activator in fibroblasts transformed by Rous sarcoma virus

, 1978
B. Wolf, Allan R. Goldberg
openalex   +1 more source

Clinical utility of consecutive volume scanning dual‐energy CT in differentiating hemorrhage from contrast staining in ischemic stroke patients

Journal of Applied Clinical Medical Physics, Volume 26, Issue 9, September 2025.
Abstract Background and Purpose Accurate differentiation between hemorrhage and iodinated contrast staining is critical for managing ischemic stroke patients following revascularization. While dual‐energy CT (DECT) has shown promise in this context, studies have predominantly focused on dual‐source or fast‐kV switching systems. This study evaluates the
Aroon Pressram, Reordan DeJesus, Tara Massini, Anna Y. Khanna, Manuel Arreola, Izabella L. Barreto   +5 more
wiley   +1 more source

Mechanism of Activation of Human Plasminogen by Streptokinase

, 1972
K.Nagendra Nath Reddy, Gabor Markus
openalex   +1 more source

Data‐Driven Cluster Analysis of Cerebrospinal Fluid Proteome and Associations with Clinical Phenotypes in Systemic Lupus Erythematosus

ACR Open Rheumatology, Volume 7, Issue 9, September 2025.
Objective To explore the cerebrospinal fluid (CSF) proteome in systemic lupus erythematosus (SLE) and the associations between the CSF proteomic patterns and clinical manifestations. Methods CSF samples from 29 female outpatients with SLE were analyzed with label‐free liquid chromatography tandem mass spectrometry.
Elsa Grenmyr, Kristoffer Zervides, Seyed Morteza Najibi, Birgitta Gullstrand, Charlotte Welinder, Jessika Nystedt, Petra C. Nilsson, Pia C. Sundgren, Robin Kahn, Andreas Jönsen, Anders A. Bengtsson   +10 more
wiley   +1 more source

Mechanism of the urokinase-catalyzed activation of human plasminogen.

, 1976
Bernard N. Violand, Francis Castellino
openalex   +1 more source

Clinical Features, Molecular Biology, and the Metastatic Microenvironment in Lung Cancer Brain Metastases: Implications for Treatment Decisions

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Brain metastases (BM) from lung cancer are aggressive with poor prognosis. This review covers clinical features, diagnosis, early metastasis, and multi‐omics‐elucidated mechanisms, especially the tumor microenvironment of lung cancer with BM. It also discusses preclinical models, signaling pathways, and emerging therapies.
Yixiang Zhu, Danming He, Zan Hou, Mei Lan, Ye Zhang, Qifeng Wang   +5 more
wiley   +1 more source

DNase I‐Mediated Chemotactic Nanoparticles for NETs Targeting and Microenvironment Remodeling Treatment of Acute Ischemic Stroke

Advanced Science, Volume 12, Issue 34, September 11, 2025.
The neutrophil extracellular traps (NETs) play an important role in reperfusion injury in ischemic stroke. Here, considering the unique vascular localization of NETs, a DNase I‐mediated NETs‐targeting nanoparticle is developed to integrate the catalytic and chemotactic functions of DNase I and achieve the synergistic regulation of the internal and ...
Tongyu Zhang, Peixin Liu, Wenru Shen, Chao Li, Zhenhao Zhao, Yuxing Wu, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source