Results 241 to 250 of about 136,149 (288)

Importance of the interaction between plasminogen and fibrin for plasminogen activation by tissue-type plasminogen activator

Thrombosis Research, 1984
The potentiating effect of fibrin monomer on plasminogen activation by tissue-type plasminogen activator is much more important with lys-plasminogen than with mini-plasminogen (which lacks the high affinity lysine-binding site important for binding to fibrin).
F W, Dunn, K, Deguchi, J, Soria, C, Soria, H R, Lijnen, G, Tobelem, J, Caen   +6 more
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Conformational Studies of Human Plasminogen and Plasminogen Fragments: Evidence for a Novel Third Conformation of Plasminogen

Biochemistry, 1994
The conformations of Glu-plasminogen and defined proteolytic fragments, in the presence and absence of 6-aminohexanoic acid (6-AHA), trans-4-(aminomethyl)cyclohexanecarboxylic acid (t-AMCHA), and benzamidine, were studied using three methods: size-exclusion high-performance liquid chromatography (SE-HPLC), small-angle X-ray scattering (SAXS), and ...
J M, Marshall, A J, Brown, C P, Ponting
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Annexin II: a plasminogen-plasminogen activator co-receptor

Frontiers in Bioscience, 2002
Fibrinolysis is a precisely orchestrated process in which fibrin-containing thrombi are solubilized. Several receptors regulate this process by localizing proteolytic activity to the cell surface. One such receptor is annexin II, a calcium and phospholipid-binding protein.
Jiyun, Kim, Katherine A, Hajjar
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Activation of Bovine Plasminogen by the Plasminogen Activator in Animal Tissue

Thrombosis and Haemostasis, 1960
Summary1. The activation of bovine plasminogen by means of the plasminogen activator from pig heart tissue has been studied on heated fibrin and on casein.2. Small, but varying, amounts of activator can be extracted from crude activator powder during the experiment and interfere therefore with estimations on normal, plasminogen containing fibrin.3. The
T, ABE, T, ASTRUP
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Fluorescence polarization assay of plasmin, plasminogen, and plasminogen activator

Analytical Biochemistry, 1980
Abstract We describe two assay methods for plasminogen activator (urokinase) employing the fluorescence polarization technique. One method utilizes fluoroscein isothiocyanate-labeled plasminogen as the substrate for urokinase (direct method), and the other utilizes the new plasmin generated from plasminogen by urokinase, for which fluoroscein ...
K, Kinoshita, H, Maeda, Y, Hinuma
openaire   +2 more sources

Plasminogen/plasminogen activator and growth factor activation.

Ciba Foundation symposium, 1997
The plasminogen/plasminogen activator system is widely used in extracellular proteolysis. In this review the involvement of this system in tumour invasion, cell migration, growth factor presentation and inhibition of angiogenesis are discussed.
Rifkin, DB, Gleizes, PE, Harpel, J, Nunes, I, Munger, J, Mazzieri, R, Noguera, I   +6 more
openaire   +4 more sources

STUDIES ON PLASMINOGEN: I. FURTHER PURIFICATION OF BOVINE PLASMINOGEN

Canadian Journal of Biochemistry and Physiology, 1961
Crude bovine plasminogen, prepared from bovine serum by 30% saturation with ammonium sulphate, was partially purified by isoelectric precipitation at pH 5.3, then purified by chromatography on columns of diethylaminoethyl-cellulose. Additional purification of the column product was obtained by precipitation of plasminogen from solution with potassium ...
E R, COLE, E T, MERTZ
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Plasminogen activation by tissue plasminogen activator in the presence of platelets

Thrombosis Research, 1988
Platelets were found to provide a surface for activation of plasminogen by the tissue-type plasminogen activator (t-PA) at an optimum concentration and to potentiate the generation of plasmin by the amidolytic method, fibrin lysis time and fibrin plate method.
K, Deguchi, S, Shirakawa
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Studies on plasminogen. VII. Mechanism of activation of bovine plasminogen

Canadian Journal of Biochemistry, 1969
Native bovine plasminogen is converted to an altered plasminogen and then to plasmin I by either urokinase, plasmin I, or plasmin II. Plasmin I is converted by self-catalysis to plasmin II. Plasmin II degrades itself to the inactive fragment peptide A.
L M, Hoepfinger, E T, Mertz
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Plasminogen and plasminogen proactivator in liver diseases.

Medecine interne, 1989
The behaviour of plasminogen (PLg) and plasminogen proactivator (PPLg) and some currently employed enzyme parameters were prospectively studied in 1047 subjects, of whom: 748 patients with liver diseases and jaundice; 52 tumor patients and 247 healthy persons.
H P, Boyadjian, R N, Bakalova
openaire   +1 more source