Results 261 to 270 of about 136,538 (301)

Plasminogen activation by tissue plasminogen activator in the presence of platelets

Thrombosis Research, 1988
Platelets were found to provide a surface for activation of plasminogen by the tissue-type plasminogen activator (t-PA) at an optimum concentration and to potentiate the generation of plasmin by the amidolytic method, fibrin lysis time and fibrin plate method.
K, Deguchi, S, Shirakawa
openaire   +2 more sources

Studies on plasminogen. VII. Mechanism of activation of bovine plasminogen

Canadian Journal of Biochemistry, 1969
Native bovine plasminogen is converted to an altered plasminogen and then to plasmin I by either urokinase, plasmin I, or plasmin II. Plasmin I is converted by self-catalysis to plasmin II. Plasmin II degrades itself to the inactive fragment peptide A.
L M, Hoepfinger, E T, Mertz
openaire   +2 more sources

Plasminogen and plasminogen proactivator in liver diseases.

Medecine interne, 1989
The behaviour of plasminogen (PLg) and plasminogen proactivator (PPLg) and some currently employed enzyme parameters were prospectively studied in 1047 subjects, of whom: 748 patients with liver diseases and jaundice; 52 tumor patients and 247 healthy persons.
H P, Boyadjian, R N, Bakalova
openaire   +1 more source

Plasminogen activator and cancer

European Journal of Cancer and Clinical Oncology, 1984
Plasminogen activator is a protease which catalyses the conversion of the inactive plasminogen to the active plasmin. Most transformed cell lines and solid tumors produce elevated levels of plasminogen activator compared with nontransformed counterparts. This increased synthesis of plasminogen activator may play a role in tumorigenesis, cancer invasion
M J, Duffy, P, O'Grady
openaire   +2 more sources

Plasminogen polymorphism in swine

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1989
1. Plasminogen polymorphism in swine (Sus scrofa) plasma was demonstrated by immunoblotting. 2. Eleven plasminogen phenotypic patterns, including a null pattern, were detected. 3. The null pattern was associated with extremely low plasma triglyceride and increased unesterified cholesterol levels. 4.
J, Rapacz, Z, Reiner, S Q, Ye, J, Hasler-Rapacz, J, Rapacz, W J, McConathy   +5 more
openaire   +2 more sources

Mechanisms of plasminogen activation

Journal of Internal Medicine, 1994
The fibrinolytic system consists of an inactive proenzyme, plasminogen, that is converted by plasminogen activators to the active enzyme, plasmin, that degrades fibrin. Two immunologically distinct plasminogen activators have been identified: tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA).
H R, Lijnen, F, Bachmann, D, Collen, V, Ellis, H, Pannekoek, D C, Rijken, S, Thorsen   +6 more
openaire   +2 more sources

Plasminogen.

Brain research. Gene expression patterns, 2007
Plasminogen activator inhibitor-2 (PAI-2) specifically inhibits plasminogen activators, extracellular fibrinolytic serine proteases that are also implicated in brain plasticity and toxicity. Primarily localized intracellularly, PAI-2 is thought to also counteract apoptosis mediated by a currently undefined intracellular protease.
R, Sharon, R, Abramovitz, R, Miskin
openaire   +1 more source

Plasminogen activator / plasminogen activator inhibitors in ovarian physiology

Frontiers in Bioscience, 2004
The target extracellular matrix (ECM) degradation generated by plasminogen activator (PA) and regulated by plasminogen activator inhibitor (PAI) is an event that affects a wide variety of physiological and pathological processes in the ovary. Studies carried out over the past 25 years in a number of laboratories have elucidated some of the biochemical ...
openaire   +2 more sources

Plasminogen and Tissue Plasminogen Activator Interact with Antithrombin III

Thrombosis Research, 2000
Human antithrombin III was demonstrated to bind plasminogen specifically in a time and concentration-dependent manner. The above binding was also confirmed using ligand western blot assays. The interaction of plasminogen was significantly (>90%) inhibited by lysine, indicating the involvement of kringles in binding antithrombin III.
openaire   +2 more sources

Genetic Polymorphism of Plasminogen

Haemostasis, 1988
By isoelectric focusing in a pH range of pH 3.5 – 9.5 or of pH 5–8, and by using a functional or an immunological detection, a genetic polymorphism of plasminogen can be demonstrated. In Caucasoids, 2 common alleles – PLG*A (frequency 0.67) and PLG*B (frequency 0.30) – as well as several rare variants (sum of their frequencies 0.03) exist.
openaire   +2 more sources