Results 261 to 270 of about 151,729 (305)

Plasminogen/plasminogen activator and growth factor activation.

Ciba Foundation symposium, 1997
The plasminogen/plasminogen activator system is widely used in extracellular proteolysis. In this review the involvement of this system in tumour invasion, cell migration, growth factor presentation and inhibition of angiogenesis are discussed.
Rifkin, DB, Gleizes, PE, Harpel, J, Nunes, I, Munger, J, Mazzieri, R, Noguera, I   +6 more
openaire   +4 more sources

Fluorescence polarization assay of plasmin, plasminogen, and plasminogen activator

Analytical Biochemistry, 1980
Abstract We describe two assay methods for plasminogen activator (urokinase) employing the fluorescence polarization technique. One method utilizes fluoroscein isothiocyanate-labeled plasminogen as the substrate for urokinase (direct method), and the other utilizes the new plasmin generated from plasminogen by urokinase, for which fluoroscein ...
K, Kinoshita, H, Maeda, Y, Hinuma
openaire   +2 more sources

STUDIES ON PLASMINOGEN: I. FURTHER PURIFICATION OF BOVINE PLASMINOGEN

Canadian Journal of Biochemistry and Physiology, 1961
Crude bovine plasminogen, prepared from bovine serum by 30% saturation with ammonium sulphate, was partially purified by isoelectric precipitation at pH 5.3, then purified by chromatography on columns of diethylaminoethyl-cellulose. Additional purification of the column product was obtained by precipitation of plasminogen from solution with potassium ...
E R, COLE, E T, MERTZ
openaire   +2 more sources

Plasminogen activation by tissue plasminogen activator in the presence of platelets

Thrombosis Research, 1988
Platelets were found to provide a surface for activation of plasminogen by the tissue-type plasminogen activator (t-PA) at an optimum concentration and to potentiate the generation of plasmin by the amidolytic method, fibrin lysis time and fibrin plate method.
K, Deguchi, S, Shirakawa
openaire   +2 more sources

Annexin II: a plasminogen-plasminogen activator co-receptor

Frontiers in Bioscience, 2002
Fibrinolysis is a precisely orchestrated process in which fibrin-containing thrombi are solubilized. Several receptors regulate this process by localizing proteolytic activity to the cell surface. One such receptor is annexin II, a calcium and phospholipid-binding protein.
Jiyun, Kim, Katherine A, Hajjar
openaire   +2 more sources

Studies on plasminogen. VII. Mechanism of activation of bovine plasminogen

Canadian Journal of Biochemistry, 1969
Native bovine plasminogen is converted to an altered plasminogen and then to plasmin I by either urokinase, plasmin I, or plasmin II. Plasmin I is converted by self-catalysis to plasmin II. Plasmin II degrades itself to the inactive fragment peptide A.
L M, Hoepfinger, E T, Mertz
openaire   +2 more sources

Plasminogen and plasminogen proactivator in liver diseases.

Medecine interne, 1989
The behaviour of plasminogen (PLg) and plasminogen proactivator (PPLg) and some currently employed enzyme parameters were prospectively studied in 1047 subjects, of whom: 748 patients with liver diseases and jaundice; 52 tumor patients and 247 healthy persons.
H P, Boyadjian, R N, Bakalova
openaire   +1 more source

Plasminogen activator / plasminogen activator inhibitors in ovarian physiology

Frontiers in Bioscience, 2004
The target extracellular matrix (ECM) degradation generated by plasminogen activator (PA) and regulated by plasminogen activator inhibitor (PAI) is an event that affects a wide variety of physiological and pathological processes in the ovary. Studies carried out over the past 25 years in a number of laboratories have elucidated some of the biochemical ...
openaire   +2 more sources

Plasminogen.

Brain research. Gene expression patterns, 2007
Plasminogen activator inhibitor-2 (PAI-2) specifically inhibits plasminogen activators, extracellular fibrinolytic serine proteases that are also implicated in brain plasticity and toxicity. Primarily localized intracellularly, PAI-2 is thought to also counteract apoptosis mediated by a currently undefined intracellular protease.
R, Sharon, R, Abramovitz, R, Miskin
openaire   +1 more source

Plasminogen and Tissue Plasminogen Activator Interact with Antithrombin III

Thrombosis Research, 2000
Human antithrombin III was demonstrated to bind plasminogen specifically in a time and concentration-dependent manner. The above binding was also confirmed using ligand western blot assays. The interaction of plasminogen was significantly (>90%) inhibited by lysine, indicating the involvement of kringles in binding antithrombin III.
openaire   +2 more sources