Results 251 to 260 of about 136,149 (288)
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Plasminogen activator and cancer
European Journal of Cancer and Clinical Oncology, 1984Plasminogen activator is a protease which catalyses the conversion of the inactive plasminogen to the active plasmin. Most transformed cell lines and solid tumors produce elevated levels of plasminogen activator compared with nontransformed counterparts. This increased synthesis of plasminogen activator may play a role in tumorigenesis, cancer invasion
M J, Duffy, P, O'Grady
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Plasminogen polymorphism in swine
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19891. Plasminogen polymorphism in swine (Sus scrofa) plasma was demonstrated by immunoblotting. 2. Eleven plasminogen phenotypic patterns, including a null pattern, were detected. 3. The null pattern was associated with extremely low plasma triglyceride and increased unesterified cholesterol levels. 4.
J, Rapacz +5 more
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Mechanisms of plasminogen activation
Journal of Internal Medicine, 1994The fibrinolytic system consists of an inactive proenzyme, plasminogen, that is converted by plasminogen activators to the active enzyme, plasmin, that degrades fibrin. Two immunologically distinct plasminogen activators have been identified: tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA).
H R, Lijnen +6 more
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Plasminogen activator / plasminogen activator inhibitors in ovarian physiology
Frontiers in Bioscience, 2004The target extracellular matrix (ECM) degradation generated by plasminogen activator (PA) and regulated by plasminogen activator inhibitor (PAI) is an event that affects a wide variety of physiological and pathological processes in the ovary. Studies carried out over the past 25 years in a number of laboratories have elucidated some of the biochemical ...
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Plasminogen and Tissue Plasminogen Activator Interact with Antithrombin III
Thrombosis Research, 2000Human antithrombin III was demonstrated to bind plasminogen specifically in a time and concentration-dependent manner. The above binding was also confirmed using ligand western blot assays. The interaction of plasminogen was significantly (>90%) inhibited by lysine, indicating the involvement of kringles in binding antithrombin III.
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Brain research. Gene expression patterns, 2007
Plasminogen activator inhibitor-2 (PAI-2) specifically inhibits plasminogen activators, extracellular fibrinolytic serine proteases that are also implicated in brain plasticity and toxicity. Primarily localized intracellularly, PAI-2 is thought to also counteract apoptosis mediated by a currently undefined intracellular protease.
R, Sharon, R, Abramovitz, R, Miskin
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Plasminogen activator inhibitor-2 (PAI-2) specifically inhibits plasminogen activators, extracellular fibrinolytic serine proteases that are also implicated in brain plasticity and toxicity. Primarily localized intracellularly, PAI-2 is thought to also counteract apoptosis mediated by a currently undefined intracellular protease.
R, Sharon, R, Abramovitz, R, Miskin
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Genetic Polymorphism of Plasminogen
Haemostasis, 1988By isoelectric focusing in a pH range of pH 3.5 – 9.5 or of pH 5–8, and by using a functional or an immunological detection, a genetic polymorphism of plasminogen can be demonstrated. In Caucasoids, 2 common alleles – PLG*A (frequency 0.67) and PLG*B (frequency 0.30) – as well as several rare variants (sum of their frequencies 0.03) exist.
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Zymographic Evaluation of Plasminogen Activators and Plasminogen Activator Inhibitors
2004Publisher Summary The plasminogen activator/plasminogen activator inhibitor (PA/PAI) system is of considerable fundamental importance in elucidating the biochemical mechanisms of many physiological and patho-physiological processes. Although many techniques are available to assess the PA/PAI system, including ELISA and molecular assays, fibrin ...
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Thrombotic Manifestations in Plasminogen Deficiency and in Plasminogen Abnormalities
Thrombosis and Haemostasis, 1988GIROLAMI, ANTONIO +2 more
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Interaction of Plasminogen Activators and Inhibitors with Plasminogen and Fibrin
Seminars in Thrombosis and Hemostasis, 1982H R, Lijnen, D, Collen
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