Results 231 to 240 of about 241,553 (351)

Iron enhances reactive oxygen species generation and initiates neutrophil extracellular traps formation on the endothelium to exacerbate stroke

Journal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
Under hypoxic conditions, iron from red blood cells and injured tissues is taken up by endothelial cells. During reoxygenation, this iron is exported via Fpn1, promoting NETs formation by enhancing ROS production through the Fenton reaction, ultimately exacerbating cerebral injury.
Weijian Fan, Zebin Fang, Yuxiang Weng, Tianxiang Zhan, Kaiyuan Huang, Jianwei Pan, Renya Zhan   +6 more
wiley   +1 more source

Disrupting BMP/TGF‐β Signaling: Modulation of AQP1 and TGFB1 in Human Pulmonary Microvascular Endothelial Cells

Comprehensive Physiology, Volume 15, Issue 6, December 2025.
Evaluation of targeted gene silencing and exogenous BMP9 administration in HPMECs. AQP1 silencing decreased TGFB1, TGFBR1, and BMPR2 expression, while BMP9 administration returned TGFB1 to basal levels. TGFB1 silencing upregulated BMP9, while downregulating BMP10 and BMPR2 expression. BMP9 administration downregulated AQP1 expression.
Chrysi Keskinidou, Nikolaos S. Lotsios, Kostas A. Papavassiliou, Athanasios G. Papavassiliou, Ioanna Dimopoulou, Anastasia Kotanidou, David Langleben, Stylianos E. Orfanos, Alice G. Vassiliou   +8 more
wiley   +1 more source

uPAR and cFn as candidate protein biomarkers for identifying low response to rtPA in acute ischemic stroke. [PDF]

Eur J Med Res
Wang Y, Huang Y, Li F, Han Z, Yang Z, Zhong L, Li L, Zhao H, Fan J, Zheng Y, Borlongan C, Luo Y.   +11 more
europepmc   +1 more source

Multiple gene duplication in the evolution of plasminogen. Five regions of sequence homology with the two internally homologous structures in prothrombin

, 1976
H. Claeys, Lars Sottrup‐Jensen, Maria E. Blair Zajdel, Torben E. Petersen, Staffan Magnusson   +4 more
openalex   +1 more source

Orosomucoid 1 Participates in Alveolar Hypercoagulation and Fibrinolytic Inhibition Involving NF‐κB Signaling Pathway in LPS‐Induced ARDS

The FASEB Journal, Volume 39, Issue 21, 15 November 2025.
ORM1 promotes LPS‐induced ARDS by activating NF‐κB in alveolar epithelial II cells, upregulating TF/PAI‐1 to cause hypercoagulation and fibrinolysis inhibition, leading to lung injury. ORM1 knockdown reverses these effects, indicating therapeutic potential.
Xianjun Chen, Ying Liu, Song Mu, Tingting Chen, Jia Yuan, Chuan Xiao, Qi Dong, Qing Li, Ying Wang, Qimin Chen, Shuwen Li, Wei Li, Feng Shen   +12 more
wiley   +1 more source

Mesomycoplasma hyopneumoniae lipoprotein Mhp390 serves as a plasminogen receptor mediating extracellular matrix degradation and respiratory epithelial cells injury. [PDF]

Vet Res
Liu W, Ye L, Yang K, Yan X, Gao T, Yuan F, Guo R, Liu Z, Li C, Wu Q, Zhu J, Tian Y, Tang B, Song Q, Zhou D.   +14 more
europepmc   +1 more source

Activin A–Activated ALK4 Induces Pathogenic Th17‐Involved Endothelial–Mesenchymal Transition in Systemic Lupus Erythematosus–Associated Pulmonary Arterial Hypertension

Arthritis &Rheumatology, Volume 77, Issue 11, Page 1533-1547, November 2025.
Objective Autoimmune diseases, such as systemic lupus erythematosus (SLE), are associated with pulmonary arterial hypertension (PAH), a condition that can lead to heart failure. However, whether T cells also contribute to the occurrence of PAH in SLE has not been clarified.
Shuliang Jing, Junyan Qian, Hongjie Ying, Pei Mao, Mingxin Yao, Zhihong Wu, Harm J. Bogaard, Lie Wang, Mengtao Li, Jun Yang   +9 more
wiley   +1 more source

Identifying the role of aging-related genes in intracranial aneurysms through bioinformatics analysis. [PDF]

Chin Neurosurg J
Kang J, Tian S, Xu X, Yang G.
europepmc   +1 more source

Enhancing patient stratification methods for medication review during acute admissions

British Journal of Clinical Pharmacology, Volume 91, Issue 11, Page 3279-3287, November 2025.
Medication review in the hospital is an effective tool for identifying inappropriate prescribing, but not every patient can receive one due to resource constraints. Thus, it is important to identify patients who stand to benefit most from medication review.
Louise Westberg Strejby Christensen, Helle Gybel Juul‐Larsen, Line Jee Hartmann Rasmussen, Esben Iversen, Kim Peder Dalhoff, Ove Andersen, Morten Baltzer Houlind   +6 more
wiley   +1 more source

Clinical Outcomes of Intravenous Thrombolysis in Acute Ischemic Stroke: A Prospective Observational Study From Mumbai. [PDF]

Cureus
Solapure V, Gore S, Shah K, Shah P.
europepmc   +1 more source