Results 231 to 240 of about 101,655 (293)

The Role of CAF‐derived Vitronectin in Promoting Colorectal Cancer Progression and Immunosuppression

Advanced Science, Volume 12, Issue 33, September 4, 2025.
Cancer‐associated fibroblast (CAF)‐derived VTN upregulates SLC6A8 expression in colorectal cancer (CRC) cells and macrophages through enhanced FAK phosphorylation. This modulation significantly increases the cellular uptake of creatine and ATP, promoting cancer progression and macrophage polarization.
Jiahua Yu, Mengxi Xiu, Shijun Yu, Zhiqin Chen, Yandong Li, Yong Gao   +5 more
wiley   +1 more source

Application of the Mass Spectrometry–High‐Throughput Technique Over the Immunohistochemical Analysis for Human Brain Tumor Diagnosis and Prognosis: Insights Into Biomarkers' Identification for the Case Study of Grade IV Astrocytomas and Meningiomas

Biomedical Chromatography, Volume 39, Issue 9, September 2025.
ABSTRACT Human brain tumors were commonly monitored in hospital/clinical laboratories by immunohistochemistry (IHC) technique, which provides major insights into their classification. However, this technique remains laborious and still shows pitfalls. Therefore, the current study was endeavored to reveal the assets of the application of high‐throughput
Kaouthar Louati, Fatma Kolsi, Manel Mellouli, Hanen Louati, Rim Kallel, Rania Zribi, Mahdi Borni, Leila Sellami Hakim, Amina Maalej, Sirine Choura, Mohamed Chamkha, Sami Sayadi, Zouheir Khemakhem, Tahya Sellami Boudawara, Mohamed Zaher Boudawara, Kaouthar Zribi, Fathi Safta   +16 more
wiley   +1 more source

Efficacy and Safety of Tenecteplase in Acute Ischemic Stroke: A Meta‐Analysis of Randomized Controlled Trials

Brain and Behavior, Volume 15, Issue 9, September 2025.
This meta‐analysis of randomized controlled trials evaluated tenecteplase versus standard treatment in acute ischemic stroke. Tenecteplase enhanced recanalization and NIHSS scores but showed higher early symptomatic intracranial hemorrhage. No notable differences were seen in mortality or functional independence, supporting cautious use in selected ...
Zaryab Bacha, Javeria Javed, Maheen Sheraz, Muhammad Abdullah Ali, M. Ehtisham Wali Khan, Sufyan Shahid, Asad Iqbal, Mahnoor Qasim, Abdullah Afridi, Fazia Khattak, Fathimathul Henna, Mazhar Ali Shah, Raheel Ahmed   +12 more
wiley   +1 more source

Cerebral Venous Thrombosis:Current Status and Challenges

Brain and Behavior, Volume 15, Issue 9, September 2025.
Our review introduces treatment strategies for short‐term, long‐term, and permanent CVT risk factors, focusing on anticoagulant selection and treatment duration. We also discuss the current status of endovascular therapy for CVT, noting that it remains a challenge due to limited evidence, and more research is needed to optimize this approach.
Wenbo Zuo, Shengcai Chen, Jiashuo Lin, Yan Wan, Fei Cao, Bo Hu   +5 more
wiley   +1 more source

Systematic Exploration of Potential Druggable Genes for Ischemic Stroke Employing Genome‐Wide Mendelian Randomization Analysis

Brain and Behavior, Volume 15, Issue 9, September 2025.
This study identified six potential druggable genes (CALCRL, KCNJ11, NEK3, THSD1, MMP12, and HSD17B12) associated with ischemic stroke risk using a systematic druggable genome‐wide Mendelian randomization analysis. ABSTRACT Background Ischemic stroke (IS) treatment remains a significant challenge.
Peng Zhang, Yulu He, Qing Zhen, Yan Zhang   +3 more
wiley   +1 more source

Cellular Senescence and Immunosenescence in Melanoma: Insights From the Tumor Microenvironment

Cancer Medicine, Volume 14, Issue 17, September 2025.
ABSTRACT Background Melanoma is one of the most immunogenic malignancies, yet resistance to immune checkpoint inhibitors (ICIs) remains a major obstacle to durable therapeutic success. Emerging evidence indicates that aging‐related processes, including cellular senescence and immunosenescence, can reshape the tumor microenvironment (TME) to favor ...
Lihua Xiong, Jian Cheng
wiley   +1 more source

A Review on Biomarker‐Enhanced Machine Learning for Early Diagnosis and Outcome Prediction in Ovarian Cancer Management

Cancer Medicine, Volume 14, Issue 17, September 2025.
ABSTRACT Background Ovarian cancer (OC) remains the most lethal gynecological malignancy, largely due to its late‐stage diagnosis and nonspecific early symptoms. Advances in biomarker identification and machine learning offer promising avenues for improving early detection and prognosis.
Somayyeh Hormaty, Anwar Nather Seiwan, Bushra H. Rasheed, Hanieh Parvaz, Ali Gharahzadeh, Hamid Ghaznavi   +5 more
wiley   +1 more source

Navigating the Uncertainties of Antithrombotic Therapy After Transcatheter Patent Foramen Ovale Closure: A Comprehensive Review

Catheterization and Cardiovascular Interventions, Volume 106, Issue 3, Page 2037-2047, September 1, 2025.
ABSTRACT The patent foramen ovale (PFO), present in 25% of the population, can cause paradoxical embolism and stroke. Transcatheter PFO closure is the gold standard for recurrent embolism with significant inter‐atrial shunting, with recent trials confirming its superiority in reducing ischemic stroke recurrence over medical therapy.
Eirini Beneki, Kyriakos Dimitriadis, Nikolaos Pyrpyris, Georgios Tzimas, Ioannis Skalidis, David Meier, Panagiotis Antiochos, Panagiotis Kostakis, Efthymia Pavlou, Francesco Perone, Georgios Tsivgoulis, Constantina Aggeli, Ole de Backer, Konstantinos Tsioufis   +13 more
wiley   +1 more source

Curcumin and Resveratrol as Dual Modulators of the STAT3 Pathway in Lung Cancer: A Comprehensive Review

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
The STAT3 pathway plays a crucial role in lung cancer by regulating cell proliferation, survival, angiogenesis, invasion, and metastasis. CUR and RES have emerged as potential therapeutic agents due to their ability to inhibit the STAT3 pathway, reducing tumor growth, angiogenesis, migration, and invasion.
Mohammad Yasin Zamanian, Klavdiya A. Turkadze, Mehraveh Sadeghi Ivraghi, Maryam Golmohammadi, Maryam Sharifi, Zahra Keshtpour Amlashi   +5 more
wiley   +1 more source

Neurobiological Synergy of Plant and Animal Sources of Omega‐3 and Exercise in Aging: Implications for Molecular Signaling, Memory, Spatial Learning, and Brain Function

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
Omega‐3 fatty acids from animal sources, combined with exercise, modulate key molecular pathways to enhance neurogenesis, synaptic plasticity, and antioxidant defenses. These interventions also increase tissue plasminogen activator activity, promoting both amyloid‐β degradation and proBDNF cleavage into BDNF, thereby reducing neurodegeneration and ...
Yikuang Hao, Sima‐sadat Sabihi
wiley   +1 more source