Research progress of neurovascular units involved in ischemic stroke
Ibrain, Volume 11, Issue 4, Page 492-503, Winter 2025.The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang +4 more
wiley +1 more source
Hormonal Regulation of Urokinase- and Tissue-Type Plasminogen Activator in Mouse Sertoli Cells. [PDF]
Mol Reprod DevCarosi S +6 more
europepmc +1 more source
The epidemiology and pathogenesis of uterine fibroids
International Journal of Gynecology &Obstetrics, Volume 171, Issue 3, Page 1029-1045, December 2025.Abstract Uterine fibroids, or leiomyomas, are the most common benign tumors of the female reproductive tract, ultimately affecting a majority of women worldwide, primarily during their reproductive years. While their origin appears genetic, manifesting in monoclonal tumors, diverse features and mechanisms contribute to their growth and further ...
Malcolm G. Munro +2 more
wiley +1 more source
The Value of Soluble Urokinase Plasminogen Activator Receptor (suPAR) as Predictive Tool in Hospitalised Patients With Community-Acquired Pneumonia (CAP). [PDF]
Clin Respir JHessels L +5 more
europepmc +1 more source
Extracellular Vesicles in Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic Opportunities
iNew Medicine, Volume 1, Issue 1, December 2025.The role of extracellular vesicles (EVs) in the progression of nonalcoholic fatty liver disease (NAFLD). Donor cells release EVs containing various molecules such as cholesterol, ceramide, sphingomyelin, miRNA, DNA, proteins, and lipids. These EVs are taken up by multiple recipient cells including Kupffer cells, adipocytes, β cells, adipose tissue ...
Yunsheng Dong +12 more
wiley +1 more source
The Antifibrotic Effects of Plasminogen Activator Inhibitor-1 Antagonists are Observed in Rats with Epidural Fibrosis. [PDF]
Sisli Etfal Hastan Tip BulBektasoglu PK +4 more
europepmc +1 more source
Risk Factors for Cardiovascular and Metabolic Disease: Integrating Traditional and Novel Paradigms
iNew Medicine, Volume 1, Issue 1, December 2025.ABSTRACT Cardiovascular and metabolic diseases (CVMD), encompassing atherosclerotic cardiovascular disease (ASCVD), heart failure, obesity, type 2 diabetes mellitus (T2DM), and metabolic dysfunction‐associated steatotic liver disease (MASLD), remain the leading global cause of morbidity and mortality.
Zhihua Wang +3 more
wiley +1 more source
A nomogram model for prognosis of acute ischemic stroke treated with recombinant tissue-type plasminogen activator. [PDF]
Front NeurolBai S, Liu Y, Zhang C, Ren Y.
europepmc +1 more source
The Journal of Clinical Pharmacology, Volume 65, Issue 12, Page 1844-1854, December 2025.Abstract Corticosteroids are effective anti‐cancer agents for treating hematologic malignancies in children. However, avascular necrosis (AVN) is a common and debilitating adverse effect, leading to bone death and impacting long‐term quality of life. This study aimed to uncover the genetic factors contributing to corticosteroid‐induced AVN in a well ...
Miguel Cordova‐Delgado +9 more
wiley +1 more source