Results 91 to 100 of about 59,929 (255)

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

British Journal of Pharmacology, EarlyView.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers   +3 more
wiley   +1 more source

Garadacimab for the long‐term prophylaxis of hereditary angioedema

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Hereditary angioedema (HAE), a rare and debilitating disease characterized by recurrent and spontaneous attacks of tissue swelling, has a high unmet therapeutic need, with many patients experiencing insufficient disease control with current prophylactic treatments.
Emel Aygören‐Pürsün, Regina Treudler, Petra Staubach, Inmaculada Martinez Saguer, Thomas Linhoff, Markus Magerl   +5 more
wiley   +1 more source

Metabolic syndrome, plasminogen activator inhibitor (pai-1) and atherosclerosis

Zdravniški Vestnik, 2005
Background: Metabolic syndrome is associated with high cardiovascular morbidity and mortality and its increasing prevalence is becoming one of the major health problems.
Alenka Mavri
doaj  

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

Effect of Plasma Soluble Urokinase-Type Plasminogen Activator Receptor and Plasminogen Activator Inhibitor-1 Levels in the Plasma of Babylon Women with Breast Cancer

Medical Journal of Babylon
Background: Worldwide, the occurrence of breast cancer is elevated as well as the number of mortality in women cancers. The movement of cancer cells from the first stage and invasion of the surrounding tissue are called cancer metastasis.
Sheerin H. Abbas, Zinah Abbass Ali, Alaa Sadiq Alaawad   +2 more
doaj   +1 more source

Urokinase-type plasminogen activator and plasminogen activator inhibitor-1 complex as a serum biomarker for COVID-19

Frontiers in Immunology
Patients with coronavirus disease-2019 (COVID-19) have an increased risk of thrombosis and acute respiratory distress syndrome (ARDS). Thrombosis is often attributed to increases in plasminogen activator inhibitor-1 (PAI-1) and a shut-down of ...
Tetiana Yatsenko, Tetiana Yatsenko, Ricardo Rios, Tatiane Nogueira, Yousef Salama, Satoshi Takahashi, Yoko Tabe, Toshio Naito, Kazuhisa Takahashi, Kazuhisa Takahashi, Koichi Hattori, Koichi Hattori, Beate Heissig   +12 more
doaj   +1 more source

Algorithms in Allergy: Hereditary Angioedema

Allergy, EarlyView.
Konrad Bork, Markus Magerl, Emel Aygören‐Pürsün, Henriette Farkas   +3 more
wiley   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

ANGIOTENSIN CONVERTING ENZYME GEN POLIMORPHISM AND ITS RELATION WITH PLASMINOGEN ACTIVATOR INHIBITOR-1 IN CHRONIC DIALYSIS PATIENTS

Turkish Journal of Nephrology, 2019
It is well known that coronary events and changes in the fibrinolytic system are common complications seen in end stage renal disease (ESRD) patients. Previous studies have shown that the activities of the enzymes of fibrinolytic pathway differ between ...
İ. Çetin ÖZENER, Emel KARIŞIK, Azra BİHORAC, Mehmet KOÇ, Turgay İSPİR, Emel AKOĞLU   +5 more
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