Results 111 to 120 of about 180,408 (257)

Deferasirox derivatives as inhibitors of Kallikrein‐related peptidases associated to neurodegenerative diseases

ChemMedChem, Accepted Article.
Kallikrein‐related peptidases are a family of serine proteases which loss of activity regulation has been particularly linked to neurodegenerative diseases. Moreover, iron overload is also a key process in some of these leading pathological conditions, particularly Alzheimer’s disease.
Rilès Boumali, Elodie David, Nancy Chaaya, Morane Lucas, Sabrina AÏT AMIRI, Valérie Lefort, Anthony Nina Diogo, Michèle Salmain, Isabelle Petropoulos, Vincent Corcé, Chahrazade El Amri, Candice Botuha   +11 more
wiley   +1 more source

Plasminogen activator inhibitor-1, free fatty acids, and insulin resistance in patients with myocardial infarction

Diabetes, Metabolic Syndrome and Obesity, 2013
Olga Gruzdeva, Evgenya Uchasova, Yulia Dyleva, Ekaterina Belik, Ekaterina Shurygina, Olga Barbarash Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences, Kemerovo, Russian ...
Gruzdeva O, Uchasova E, Dyleva Y, Belik E, Shurygina E, Barbarash O   +5 more
doaj  

Design, synthesis and evaluation of small molecules as inhibitors of plasminogen activator inhibitor-1 [PDF]

, 2014
Plasminogen activator inhibitor type-1 (PAI-1) is a member of the serine protease inhibitor (serpin) superfamily. Excessive levels of PAI-1 inhibit urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA), which regulates ...
Weerakoon, Darshani Avanthi
core   +1 more source

Inorganic Nanoparticles in Reproduction Biology: Opportunities and Challenges

ChemPlusChem, Accepted Article.
The development of inorganic metal and metal oxide nanoparticles (MNPs) has attracted significant attention in biomedical and biotechnological fields. An emerging field in this context is the use of MNPs in reproduction biology. Here, we review the development of MNPs in the field of reproduction by focusing on their interactions with highly delicate ...
Stephan Barcikowski, Sangita Kundu, Christoph Rehbock, Wilfried A. Kues   +3 more
wiley   +1 more source

Impact of PAI-1 4G/5G and C > G polymorphisms in acute ST elevation myocardial infarction and stable angina patients: A single center Egyptian study

Egyptian Journal of Medical Human Genetics, 2018
Background: Many genetic factors, including polymorphisms in the genes regulating blood coagulation and fibrinolysis have been proposed as risk factors for coronary artery disease (CAD).
Hanan Al-Wakeel, Nadia Sewelam, Mohamed Khaled, Akram Abdelbary   +3 more
doaj  

Progress toward a structure-function relationship for novel, small-molecule inhibitors of plasminogen activator inhibitor-1 [PDF]

, 2015
Plasminogen activator inhibitor-1 (PAI-1) is a serpin protein whose function is to inhibit tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), and hence, fibrinolysis.
Burke, Sarah
core   +1 more source

Current and novel biomarkers in cardiogenic shock

European Journal of Heart Failure, EarlyView.
A summary of current and novel biomarkers and their potential stages of release in cardiogenic shock. The diagram illustrates the proposed release of the biomarkers during the different stages of cardiogenic shock: progression from cardiac dysfunction/stress, through to inflammation and end‐organ dysfunction.
Victor Galusko, Florian A. Wenzl, Christophe Vandenbriele, Vasileios Panoulas, Thomas F. Lüscher, Diana A. Gorog   +5 more
wiley   +1 more source

Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA [PDF]

, 2009
HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity.
Andrew M. Schumacher, Birchmeier, Bugge, Chirgadze, Collen, Deyi Qiu, Ellis, Ellis, Gherardi, Harris, Herter, Høyer-Hansen, Itoh, Jennifer L. Harris, Juliano Alves, Jun Li, Kate A. Owen, Ke, Kemp, Kilpatrick, Kirchhofer, Kirchhofer, Lamszus, Lee, Lynette M. Kilpatrick, Mangel, Marcotte, Mars, Mars, Matsuoka, Miyazawa, Mizuno, Mohammed, Naldini, Naldini, Qiu, Rahman, Riddick, Schmidt, Shanmukhappa, Shimizu, Shimomura, Steinmetzer, Stephens, Takeuchi, Uehara, Vincent Ellis, You   +47 more
core   +3 more sources

Clinical and plasma proteomic characterization of heart failure with supranormal left ventricular ejection fraction: An emerging entity of heart failure

European Journal of Heart Failure, EarlyView.
Heart failure (HF) with supranormal ejection fraction (HFsnEF) is an unnoticed but emerging entity in HF. This study showed that HFsnEF carries a similarly increased cardiovascular risk as HF with reduced ejection fraction (HFrEF) and distinct structural and proteomic characteristics from HFrEF, warranting a further comprehensive understanding and ...
Yasuhiko Sakata, Kotaro Nochioka, Satoshi Yasuda, Koichi Ishida, Takashi Shiroto, Jun Takahashi, Shintaro Kasahara, Ruri Abe, Shinsuke Yamanaka, Takahide Fujihashi, Hideka Hayashi, Shintaro Kato, Katsunori Horii, Kanako Teramoto, Tsutomu Tomita, Satoshi Miyata, Koichiro Sugimura, Iwao Waga, Masao Nagasaki, Hiroaki Shimokawa   +19 more
wiley   +1 more source

Association between Plasma Levels of Plasminogen Activator Inhibitor-1 and Colorectal Neoplasms

Gut and Liver, 2013
Background/AimsPlasminogen activator inhibitor-1 (PAI-1) is important for tumor growth, Invasion, and metastasis. In this study, we investigated the relationship between plasma levels of PAI-1 and colorectal adenomas.Methods : We reviewed the medical ...
doaj   +1 more source