Annals of Neurology, Volume 97, Issue 6, Page 1205-1214, June 2025.Objectives Intravenous thrombolysis (IVT) is contraindicated for acute ischemic stroke (AIS) patients taking direct oral anticoagulants (DOACs) within 48 hours before index stroke. Limited data exist on off‐label use of IVT for these patients. We compared the safety and outcomes of IVT in AIS patients with DOAC treatment and patients with no OAC before
Marius Matusevicius +11 more
wiley +1 more source
Cerebrospinal fluid plasminogen activator inhibitor-1 in patients with neurological disease. [PDF]
, 1997 F O Akenami +3 more
openalex +1 more source
Tirofiban Combination Therapy for Acute Ischemic Stroke: A Systematic Review and Meta‐Analysis
Brain and Behavior, Volume 15, Issue 6, June 2025.ABSTRACT Introduction Acute ischemic stroke (AIS) is a leading cause of morbidity and mortality globally. Standard antiplatelet therapies, while partially effective, do not fully inhibit all pathways of platelet aggregation, leaving patients at risk of recurrent thrombotic events. Tirofiban, a glycoprotein IIb/IIIa receptor inhibitor, has shown promise
Abdullah Bin Kamran +9 more
wiley +1 more source
Identification of a cis-Acting Sequence in the Human Plasminogen Activator Inhibitor Type-1 Gene That Mediates Transforming Growth Factor-β1 Responsiveness in Endothelium in Vivo [PDF]
, 1996 Gang Dong +3 more
openalex +1 more source
Brain and Behavior, Volume 15, Issue 6, June 2025.The obesity paradox can be extended to stroke recurrence. A 2% reduction in recurrence risk of stroke per 1‐unit increase in BMI. ABSTRACT Objective To explore the relationship between body mass index (BMI) and the recurrence risk of stroke. Methods We searched databases, including the Web of Science, Cochrane Library, Embase, PubMed, Chinese ...
Qiuxia Qian +10 more
wiley +1 more source
Conformational Changes of the Reactive‐Centre Loop and β‐Strand 5A Accompany Temperature‐Dependent Inhibitor‐Substrate Transition of Plasminogen‐Activator Inhibitor 1 [PDF]
, 1996 Lars Kjøller +5 more
openalex +1 more source
Contemporary Perspectives on Chronic Renal Disorders
Chronic Diseases and Translational Medicine, Volume 11, Issue 2, Page 89-104, June 2025.ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok +5 more
wiley +1 more source
Neutrophil extracellular traps in cancer: From mechanisms to treatments
Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.Neutrophil extracellular traps are intricately linked to the tumor microenvironment and play a crucial role in tumorigenesis, metastasis, and related complications. Consequently, NETs‐based tumor biomarkers and therapeutic strategies warrant significant attention.
Yifan Wang +5 more
wiley +1 more source
New horizons in the pharmacological management of venous thromboembolism
HemaSphere, Volume 9, Issue 6, June 2025.Abstract Many patients suffer from venous thromboembolism (VTE) and its consequences. Despite substantial advancements with the introduction of direct oral anticoagulants (DOACs), patients and clinicians still encounter challenges in the acute and long‐term management of VTE, such as recurrent events, anticoagulant‐related bleeding complications, and ...
Andreas Verstraete +3 more
wiley +1 more source