Results 151 to 160 of about 59,929 (255)

Hepatocyte growth factor/c‐Met signaling axis in human diseases: Mechanistic insights and therapeutic potential

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun, Hao Shu, Qian Zhang, Jishan Zheng, Yunyan Ma, Dengwang Chen, Jidong Zhang, Tao Song   +7 more
wiley   +1 more source

Plasminogen activator Inhibitor-1 in systemic sclerosis: A nexus of fibrosis, vasculopathy, and senescence. [PDF]

Biomed J
Takahashi T, Takahashi T, Asano Y.
europepmc   +1 more source

A working model for CCN3 C‐terminal domain‐mediated transcriptional modulation of the plasminogen activation system

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Plasminogen is a circulating zymogen that is converted into active plasmin by plasminogen activators such as tissue plasminogen activator (tPA) and urokinase‐type PA (uPA). This conversion is regulated by plasminogen activator inhibitors (PAI‐1, PAI‐2) and by inhibitors of plasmin itself, maintaining a fine balance between activation and inhibition of ...
Bernard Perbal
wiley   +1 more source

Roles of plasminogen activator inhibitor-1 in aging-related muscle and bone loss in mice. [PDF]

Aging (Albany NY)
Ohira T, Kawao N, Mizukami Y, Okada K, Nishikawa A, Yamao H, Yamada A, Kaji H.   +7 more
europepmc   +1 more source

Programmed Cell Death in Chronic Rhinosinusitis

Clinical and Translational Allergy, Volume 16, Issue 6, June 2026.
ABSTRACT Chronic rhinosinusitis (CRS) is a prevalent upper respiratory condition characterized by a multifaceted etiology involving various cellular and molecular processes. In recent years, researchers have increasingly recognized the significance of different forms of programmed cell death (PCD), such as apoptosis and pyroptosis, in the pathological ...
Xingchen Liu, Junying Hu, Weigang Gan, Qi Wu, Bing Zhong, Feng Liu   +5 more
wiley   +1 more source

Acute portal vein thrombosis in an elderly man with homozygous mutations of plasminogen activator inhibitor-1 and methylenetetrahydrofolate reductase genes. [PDF]

Arch Med Sci
Chen J, Zhao H, Yang S, Lu H, Qi X.
europepmc   +1 more source

Toosendanin Alleviates Cerebral Ischemia/Reperfusion Injury via Inhibiting Neural Ferroptosis Through Lipid Metabolic Reprogramming in MCAO Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Post‐stroke administration of TSN significantly reduced infarct volume, neuroinflammation, and improved functional recovery of MCAO mice. TSN alleviated neural oxidative stress, lipid peroxidation, and ferroptosis in MCAO mice. TSN modulated the infiltration of immune cells in MCAO mice in vivo and T cell differentiation in vitro.
Xinyun Li, Zhiyong Zhao, Jingting Zhao, Xiangming Ye, Zhenfei Xiong, Jiejin Zhao   +5 more
wiley   +1 more source

Myocardial Infarction in a Patient With Homozygous Plasminogen Activator Inhibitor-1 (PAI-1) 4G/4G Mutation: A Case Report. [PDF]

Cureus
Manasrah A, Khan F, Yarkoni A, Kashou H, Rehman A.   +4 more
europepmc   +1 more source

Neuroprotective Effects of Phenothiazines on Acute Ischemic Stroke

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
For acute ischemic stroke due to large vessel occlusion, adjunctive neuroprotective therapy with mechanical thrombectomy is important; however, current treatment options are relatively limited. Phenothiazines such as chlorpromazine and promethazine (C + P) have shown potential neuroprotective effects in preclinical studies.
Qi Wang, Weili Li, Di Wu, Shuaili Xu, Xunming Ji   +4 more
wiley   +1 more source

Comparison of Prosigna® Assay and Urokinase Plasminogen Activator/Plasminogen Activator Inhibitor-1 Results in Early-Stage Breast Cancer Patients. [PDF]

Breast Care (Basel)
Rickerl L, Bartsch H, Harbeck N, Hofmann DM, Kolben T, Degenhardt T, Sotlar K, Wuerstlein R.   +7 more
europepmc   +1 more source