Results 161 to 170 of about 112,049 (293)

Tranexamic acid dosing in pediatric trauma: Dose simulation based on population pharmacokinetic modeling in adult trauma patients

Transfusion, EarlyView.
Abstract Background Trauma is the most common cause of death in children >1 year of age, with hemorrhage being the most common preventable cause of death after injury. Antifibrinolytics like tranexamic acid (TXA) are a key aspect of trauma management in children, but optimal dosing remains unknown.
Gideon Stitt, Kevin Downes, Athena Zuppa, Christine Leeper, Kevin Watt, Philip Spinella   +5 more
wiley   +1 more source

A contemporary review of plasminogen activator inhibitor 1 in cardiovascular disease and broader disease state implications. [PDF]

Blood Vessel Thromb Hemost
Becerra M, Soogoor N, Vu J, Wortley J, Sathyamoorthy M.   +4 more
europepmc   +1 more source

Endothelial thrombomodulin—Its role in trauma‐induced coagulopathy

Transfusion, EarlyView.
Abstract Background Trauma‐induced coagulopathy (TIC) describes a complex set of coagulation changes affecting severely injured patients. The thrombomodulin‐protein C axis is central to the evolution of TIC. Soluble thrombomodulin (sTM) levels are elevated after injury and predict poor clinical outcomes.
Jeries Abu‐Hanna, Gael B. Morrow, Gang Xu, Lewis Timms, Naveed Akbar, Michael Laffan, Robin P. Choudhury, Nicola Curry   +7 more
wiley   +1 more source

Advances in the Research of Hypoxia-Inducible Factor-1Alpha and Plasminogen Activator Inhibitor-1 in Vascular-Related Diseases. [PDF]

J Clin Med Res
Xu X, Ge XH.
europepmc   +1 more source

Role of leukocytes in hemostasis during orthotopic liver transplantation [PDF]

, 1993
Bechstein, W. O., Himmelreich, G., Huhn, D., Jochum, Marianne, Machleidt, W., Muser, M., Neuhaus, P., Riess, H., Roissaint, R.   +8 more
core   +1 more source

Estrogen as a therapeutic agent: Targeting endotheliopathy and coagulopathy in trauma

Transfusion, EarlyView.
Abstract Background Traumatic injury remains a leading cause of death, often due to uncontrolled hemorrhage and trauma‐induced coagulopathy (TIC). TIC is critically triggered by the endotheliopathy of trauma, involving endothelial cell injury and glycocalyx degradation. Despite conventional advances, the stable casualty rate underscores the urgent need
Niruktha Raghavan, Mira Patel, Bryan A. Cotton, Julia Coleman, Donald Jenkins   +4 more
wiley   +1 more source

Plasminogen Activator Inhibitor-1 Mediates Tolerance to Anti-PD-1 Immunotherapy in Non-Small Cell Lung Cancer. [PDF]

Mol Cancer Ther
Sumii M, Masuda T, Shimoji K, Yamaguchi K, Sakamoto S, Horimasu Y, Mimae T, Nakashima T, Iwamoto H, Miyata Y, Hamada H, Okada M, Miyata T, Hattori N.   +13 more
europepmc   +1 more source

An assessment of green plasma: The in vitro hemostatic superiority of a currently discarded blood product

Transfusion, EarlyView.
Abstract Introduction Recent studies have linked trauma patient outcomes to the plasma donor's sex, with premenopausal females associated with improved survival and lower organ failure. Currently, green‐colored plasma (due to oral contraceptive use) is removed from the donor pool. We set out to evaluate the hemostatic potential of green plasma.
Samantha C. Redden, David J. Sun, Yao‐Wei W. Wang, Elizabeth Hartwell, Jessica C. Cardenas, Scott D. Olson, Bryan A. Cotton   +6 more
wiley   +1 more source

Fibroblast circSamd4 promotes cardiac fibrosis via activating plasminogen activator inhibitor-1. [PDF]

Redox Biol
Chen Y, Zhang Z, Cheng Y, Chen X, Zhou J, Wei Z, Yao H, Zhang S, Kong Q, Tang H, Wu W, Zhou Z, Tang X, Liu X.   +13 more
europepmc   +1 more source

The impact of rapid infusers on the hemostatic potential of cryoprecipitate products

Transfusion, EarlyView.
Abstract Background In cases of massive transfusion, intravenous access can be limited. Additionally, delivering different products through separate lines and infusion methods adds unnecessary steps. RBC, plasma, and whole blood (WB) are delivered via rapid infusers; cryoprecipitate (CRYO) is infused through separate access and is not approved with ...
Connor D. Purvis, Samantha Redden, Andrew Jacobson, Yao‐Wei Wang, Julie Campbell, Jessica Cardenas, Jan‐Michael Van Gent, Bryan A. Cotton   +7 more
wiley   +1 more source