Results 161 to 170 of about 108,172,160 (276)

Coagulation and Fibrinolysis in Normal Pregnancy and Complicated Pregnancy

International Journal of Laboratory Hematology, Volume 48, Issue 6, Page 1455-1463, December 2026.
ABSTRACT Introduction Pregnancy induces significant physiological changes in the hemostatic system, leading to a hypercoagulable state to prevent postpartum hemorrhage. These adaptations involve alterations in coagulation and fibrinolysis, which can be further modified in complicated pregnancies such as gestational diabetes mellitus (GDM) and ...
Yang Su, Yao Wei, Cheng Liu, Yafei Gao, Xiaolong Ma, Yongxin Li, Rui Qiao   +6 more
wiley   +1 more source

Plasminogen Activator Inhibitor-1 is Internalized by Endothelial Cells via A Pinocytosis-Like Mechanism and Evades Degradation. [PDF]

FASEB J
McAdow M, Ahmetaj G, Hauschel R, Eichmann A, Sessa W.   +4 more
europepmc   +1 more source

Integration of Chemical Probes and Degradomics Reveals That Cathepsin B Functions Primarily as a Dipeptidyl Carboxypeptidase in Macrophages

ChemMedChem, Volume 21, Issue 21, 12 November 2026.
An integrated chemical biology and degradomics approach reveals the proteolytic landscape of cathepsin B in mouse macrophages. Z‐RK‐AOMK perturbs the cysteine cathepsin network and reveals that cathepsin B predominantly exhibits dipeptidyl carboxypeptidase activity in cells.
Kai‐Qi Yek, Francesca L. Apolloni, Bangyan Xu, Nghi H. Nguyen, Alexander R. Ziegler, Nichollas E. Scott, Brad E. Sleebs, Laura E. Edgington‐Mitchell   +7 more
wiley   +1 more source

Thermodynamics and selection of the plasminogen activator inhibitor-1 latency transition. [PDF]

J Biol Chem
Haynes LM, Holding ML, Woodard J, Siemieniak D, Ginsburg D.   +4 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, Volume 20, Issue 11, Page 2955-2973, November 2026.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A contemporary review of plasminogen activator inhibitor 1 in cardiovascular disease and broader disease state implications. [PDF]

Blood Vessel Thromb Hemost
Becerra M, Soogoor N, Vu J, Wortley J, Sathyamoorthy M.   +4 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, Volume 20, Issue 11, Page 2569-2583, November 2026.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Inhibition of Plasminogen Activator Inhibitor-1 (PAI-1) by Tiplaxtinin Attenuates the Aggressive Phenotype of Vulvar Squamous Cell Carcinoma Cells <i>In Vitro</i>. [PDF]

In Vivo
Warmbold J, Gallwas J, Gründker C.
europepmc   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, Volume 13, Issue 61, 3 November 2026.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Inflammatory macrophage-derived plasminogen activator inhibitor-1 exacerbates inflammation through efferocytosis inhibition. [PDF]

Cell Death Discov
Ibrahim AA, Miura H, Terada T, Kawarada M, Watanabe N, Hosokawa H, Ohtsuka M, Miyata T, Yahata T.   +8 more
europepmc   +1 more source