Plasminogen activator inhibitor-1

Results 231 to 240 of about 180,408 (257)

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2021–2022

Mass Spectrometry Reviews, Volume 44, Issue 3, Page 213-453, May/June 2025.
Abstract The use of matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this review is the 12th update of the original article published in 1999 and brings coverage of the literature to the end of 2022.
David J. Harvey
wiley +1 more source

Natural products targeting tumour angiogenesis

British Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.
Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu +2 more
wiley +1 more source

Quantitative proteomics identifies plasma protein alterations that associate with metabolic and thrombotic profile changes after bariatric surgery

Diabetes, Obesity and Metabolism, Volume 27, Issue 5, Page 2647-2657, May 2025.
Abstract Objective Roux‐en‐Y gastric bypass (RYGB) surgery has been shown to lead to favourable health outcomes in obese patients. However, the molecular changes that occur and how they relate to clinical measures are poorly understood. Here, we characterise the proteomic alterations that occur in plasma of RYGB patients before and 9 months after ...
Hasnain Ahmed +6 more
wiley +1 more source

A Novel Mechanism of the p53 Isoform Δ40p53α in Regulating Collagen III Expression in TGFβ1‐Induced LX‐2 Human Hepatic Stellate Cells

The FASEB Journal, Volume 39, Issue 8, 30 April 2025.
Δ40p53α, an N‐terminal truncated isoform of p53, regulates extracellular matrix gene expression in TGFβ1‐activated LX‐2 hepatic stellate cells. Upon liver injury, TGFβ1 signaling induces Δ40p53α, promoting its complex formation with full‐length p53 (FLp53). This complex associates with phosphorylated Smad3 in the nucleus, enhancing COL3A1 transcription
Sun‐Young Lee +3 more
wiley +1 more source

Increased levels of cathepsin B and L, urokinase-type plasminogen activator and its inhibitor type-1 as an early event in gastric carcinogenesis