Results 241 to 250 of about 112,049 (293)

Impact of Plasminogen Activator Inhibitor-1 Serum Levels and the -675 4G/5G Variant in the SERPINE1 Gene on Systemic Sclerosis in a Mexican Population. [PDF]

Life (Basel)
Lomelí-Nieto JA, Muñoz-Valle JF, Navarro-Zarza JE, Baños-Hernández CJ, Gutierrez-Brito JA, Renteria-Cabrera V, Horta-Chávez EA, Morales-Núñez JJ, García-Arellano S, Parra-Rojas I, Hernández-Bello J.   +10 more
europepmc   +1 more source

Increased plasminogen activator inhibitor-1 (PAI-1) and its associations with metabolic risk in healthy young adults with early life stress. [PDF]

Psychoneuroendocrinology
Kudinova AY, Kulak MJ, Daniels TE, Angeles WLL, de la Monte S, Mathis KJ, Beck QM, Laumann LE, Tyrka AR.   +8 more
europepmc   +1 more source

Plasminogen activator inhibitor-1 promotes immune evasion in tumors by facilitating the expression of programmed cell death-ligand 1. [PDF]

Front Immunol
Ibrahim AA, Fujimura T, Uno T, Terada T, Hirano KI, Hosokawa H, Ohta A, Miyata T, Ando K, Yahata T.   +9 more
europepmc   +1 more source

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Plasminogen Activator Inhibitor-1

Current Medicinal Chemistry, 2004
Plasminogen activator inhibitor-1 (PAI-1) is an important component of the plasminogen/plasmin system as it is the main inhibitor of tissue-type and urokinase-type plasminogen activator. Consequently, PAI-1 plays an important role in cardiovascular diseases (mainly through inhibition of t-PA) and in cell migration and tumor development (mainly through ...
Ann, Gils, Paul J, Declerck
openaire   +2 more sources

Plasminogen Activator Inhibitor-1 in Aging

Seminars in Thrombosis and Hemostasis, 2014
Plasminogen activator inhibitor-1 (PAI-1), a principal inhibitor of fibrinolysis, is induced in thrombotic, fibrotic, and cardiovascular diseases, which in turn primarily afflict the older population. This induction of PAI-1 may play an important role in the pathology of these diseases as PAI-1 can regulate the dissolution of fibrin and also inhibit ...
Koji, Yamamoto, Kyosuke, Takeshita, Hidehiko, Saito   +2 more
openaire   +2 more sources

Plasminogen Activator Inhibitor-1 and Restenosis

Current Drug Targets, 2007
Despite the introduction of drug-eluting stents restenosis remains an important clinical problem. In this review we examine the role of plasminogen activator inhibitor-1 (PAI-1) in controlling restenosis after balloon angioplasty and stent implantation.
Nadish, Garg, William P, Fay
openaire   +2 more sources

Reversible interactions between plasminogen activators and plasminogen activator inhibitor-1

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1992
We have shown that the urokinase (UK) kringle domain contains a high-affinity plasminogen activator inhibitor-1 (PAI-1) binding site, responsible for the 10-fold faster complex formation between UK and PAI-1 than between PAI-1 and low-molecular-weight urokinase (LMWUK).
J, Mimuro, M, Kaneko, T, Murakami, M, Matsuda, Y, Sakata   +4 more
openaire   +2 more sources