Results 251 to 260 of about 91,776 (288)

Zymographic Evaluation of Plasminogen Activators and Plasminogen Activator Inhibitors

2004
Publisher Summary The plasminogen activator/plasminogen activator inhibitor (PA/PAI) system is of considerable fundamental importance in elucidating the biochemical mechanisms of many physiological and patho-physiological processes. Although many techniques are available to assess the PA/PAI system, including ELISA and molecular assays, fibrin ...
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The potentiating effect of platelet on plasminogen activation by tissue plasminogen activator

Thrombosis Research, 1985
A new role for platelets in fibrinolysis is proposed. Platelets (euglobulin from platelet rich plasma and from human platelet extract) may potentiate plasminogen activation by tissue plasminogen activator (tPA). The potentiating activity was detected by both chromogenic substrate and fibrin plate analysis. The fibrinolysis-potentiating substance in the
K, Deguchi, S, Murashima, S, Shirakawa, C, Soria, J, Soria, F, Dunn, G, Tobelem   +6 more
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Differences in the activation rates of plasminogen by tissue plasminogen activator and urokinase

Thrombosis Research, 1987
The activation of a native form of plasminogen (Glu-plg) by tissue plasminogen activator(t-PA) was enhanced when the plasma was clotted by the addition of thrombin or thrombin plus Ca++. Cross-linking of fibrin in the clotted plasma did not inhibit the fibrin-associated enhancement of the activation of plasminogen by t-PA.
A, Takada, K, Shizume, M, Cho, Y, Takada
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Lipoprotein(a) inhibition of plasminogen activation by tissue-type plasminogen activator

Thrombosis Research, 1990
Here experimental evidence is presented demonstrating that Lp(a) inhibits the activation of Pg by the physiologic activator tissue-type plasminogen activator (t-PA) bound to fibrinogen fragments. The competitive inhibition constant, Kie, of the Lp(a) inhibition is 22 nM, or 8.6 mg/dL which corresponds to normal plasma ...
J M, Edelberg, M, Gonzalez-Gronow, S V, Pizzo   +2 more
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Activating effect of the plasminogen activators on plasminogens of different mammalia species

Thrombosis Research, 1995
Abstract Plasmin (E.C. 3.4.21.7.) is a major serine proteolytic enzyme responsible for fibrinolytic function in mammalia blood plasma. It is formed by activation of proenzyme plasminogen with the known activators such as urokinase (UK, E.C. 3.4.21.31.), tissue-type plasminogen activator (t-PA, E.C. 3.4.21.67.) or streptokinase (SK) (1, 2).
S A, Yakovlev, M V, Rublenko, V I, Izdepsky, E M, Makogonenko   +3 more
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Importance of the interaction between plasminogen and fibrin for plasminogen activation by tissue-type plasminogen activator

Thrombosis Research, 1984
The potentiating effect of fibrin monomer on plasminogen activation by tissue-type plasminogen activator is much more important with lys-plasminogen than with mini-plasminogen (which lacks the high affinity lysine-binding site important for binding to fibrin).
F W, Dunn, K, Deguchi, J, Soria, C, Soria, H R, Lijnen, G, Tobelem, J, Caen   +6 more
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Kinetic studies of plasminogen activation by epithelial tissue plasminogen activator

Blood Coagulation & Fibrinolysis, 1990
Initial-rate kinetic studies of the activation of plasminogen by epithelial activator were performed in the absence and in the presence of fibrinogen and CNBr-digested fibrinogen, under assay conditions similar to those described by Hoylaerts et al. (J Biol Chem, 257, 2912, 1982).
A, Electricwala, R J, Ling, T, Atkinson
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Plasminogen Activators and Plasminogen Activator Inhibitors in Neural Developmenta

Annals of the New York Academy of Sciences, 1992
N W, Seeds, S, Verrall, G, Friedman, S, Hayden, D, Gadotti, S, Haffke, K, Christensen, B, Gardner, P, McGuire, A, Krystosek   +9 more
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PLASMJN AND PLASMINOGEN ACTIVATORS: KINETICS, AND KINETICS OF PLASMINOGEN ACTIVATION

Annals of the New York Academy of Sciences, 1981
K C, Robbins, R C, Wohl, L, Summaria
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ACTIVATION OF PLASMINOGEN

Annals of the New York Academy of Sciences, 1957
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