Results 341 to 350 of about 3,326,153 (390)

Increased Bone Formation in Mice Lacking Plasminogen Activators

Journal of Bone and Mineral Research, 2003
E. Daci, V. Everts, S. Torrekens, E. Herckvan, W. Tigchelaar-Gutter, R. Bouillon, G. Carmeliet   +6 more
exaly   +2 more sources

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Inhibitory effect of angiostatins on activity of the plasminogen/plasminogen activator system

Biochemistry (Moscow), 2009
Angiostatins, kringle-containing fragments of plasminogen, are potent inhibitors of angiogenesis. Effects of three angiostatin forms, K1-3, K1-4, and K1-4.5 (0-2 microM), on the rate of native Glu-plasminogen activation by its physiological activators in the absence or presence of soluble fibrin were investigated in vitro.
N. V. Prisyazhnaya, M.Y. Levashov, L.I. Mukhametova, D. A. Gulin, S.D. Varfolomeyev, K.B. Gershkovich, R.B. Aisina   +6 more
openaire   +3 more sources

The potentiating effect of platelet on plasminogen activation by tissue plasminogen activator

Thrombosis Research, 1985
A new role for platelets in fibrinolysis is proposed. Platelets (euglobulin from platelet rich plasma and from human platelet extract) may potentiate plasminogen activation by tissue plasminogen activator (tPA). The potentiating activity was detected by both chromogenic substrate and fibrin plate analysis. The fibrinolysis-potentiating substance in the
F. W. Dunn, Claudine Soria, Katsumi Deguchi, Jeannette Soria, Gérard Tobelem, Seikou Murashima, Shigeru Shirakawa   +6 more
openaire   +3 more sources

Differences in the activation rates of plasminogen by tissue plasminogen activator and urokinase

Thrombosis Research, 1987
The activation of a native form of plasminogen (Glu-plg) by tissue plasminogen activator(t-PA) was enhanced when the plasma was clotted by the addition of thrombin or thrombin plus Ca++. Cross-linking of fibrin in the clotted plasma did not inhibit the fibrin-associated enhancement of the activation of plasminogen by t-PA.
Masaru Cho, Kengo Shizume, Akikazu Takada, Yumiko Takada   +3 more
openaire   +3 more sources

Importance of the interaction between plasminogen and fibrin for plasminogen activation by tissue-type plasminogen activator

Thrombosis Research, 1984
The potentiating effect of fibrin monomer on plasminogen activation by tissue-type plasminogen activator is much more important with lys-plasminogen than with mini-plasminogen (which lacks the high affinity lysine-binding site important for binding to fibrin).
Claudine Soria, F. W. Dunn, Jeannette Soria, K. Deguchi, J.P. Caen, H.R. Lijnen, Gérard Tobelem   +6 more
openaire   +3 more sources

Lipoprotein(a) inhibition of plasminogen activation by tissue-type plasminogen activator

Thrombosis Research, 1990
Here experimental evidence is presented demonstrating that Lp(a) inhibits the activation of Pg by the physiologic activator tissue-type plasminogen activator (t-PA) bound to fibrinogen fragments. The competitive inhibition constant, Kie, of the Lp(a) inhibition is 22 nM, or 8.6 mg/dL which corresponds to normal plasma ...
Jay M. Edelberg, Mario Gonzalez-Gronow, Salvatore V. Pizzo   +2 more
openaire   +3 more sources

Kinetic studies of plasminogen activation by epithelial tissue plasminogen activator

Blood Coagulation & Fibrinolysis, 1990
Initial-rate kinetic studies of the activation of plasminogen by epithelial activator were performed in the absence and in the presence of fibrinogen and CNBr-digested fibrinogen, under assay conditions similar to those described by Hoylaerts et al. (J Biol Chem, 257, 2912, 1982).
A Electricwala, R J Ling, Atkinson T
openaire   +3 more sources

Activating effect of the plasminogen activators on plasminogens of different mammalia species

Thrombosis Research, 1995
Abstract Plasmin (E.C. 3.4.21.7.) is a major serine proteolytic enzyme responsible for fibrinolytic function in mammalia blood plasma. It is formed by activation of proenzyme plasminogen with the known activators such as urokinase (UK, E.C. 3.4.21.31.), tissue-type plasminogen activator (t-PA, E.C. 3.4.21.67.) or streptokinase (SK) (1, 2).
Michail V. Rublenko, Sergey A. Yakovlev, Vitaliy I. Izdepsky, Eugeni M. Makogonenko   +3 more
openaire   +3 more sources

A comparison of the plasminogen activator activity units of urinary-type plasminogen activator (u-PA) and tissuetype plasminogen activator (t-PA)

Blood Coagulation & Fibrinolysis, 1992
The earliest tissue plasminogen activator (t-PA) preparations prepared from melanoma cells were expressed in urinary-type plasminogen activator (u-PA) units of activity using the u-PA International Standard (66/46). This report describes a comparison between u-PA and t-PA units by various types of fibrin plate procedure using both human and bovine ...
P. J. Gaffney, L. J. Creighton-Kempsford, J. B. Pring   +2 more
openaire   +3 more sources

Plasminogen activators, tissue degradation, and cancer.

Advances in Cancer Research, 1985
K. Danø, P. Andreasen, J. Grøndahl-Hansen, Peter Marcus Kristensen, L. Nielsen, L. Skriver   +5 more
semanticscholar   +1 more source