Transcriptome analysis reveals a de novo DNA element that may interact with chromatin-associated proteins in Plasmodium berghei during erythrocytic development [PDF]
Scientific ReportsThe life cycle of Plasmodium parasites involves intricate, multistage processes that are tightly regulated by stage-specific transcription factors. These factors bind to regulatory regions within gene promoters, enabling the precise expression of genes ...
Adaobi Okafor +3 more
doaj +2 more sources
Expression profiling of Plasmodium berghei HSP70 genes for generation of bright red fluorescent parasites. [PDF]
PLoS ONE, 2013 Live cell imaging of recombinant malarial parasites encoding fluorescent probes provides critical insights into parasite-host interactions and life cycle progression.
Marion Hliscs +3 more
doaj +2 more sources
CSP ubiquitylation favours Plasmodium berghei survival during early liver stage infection [PDF]
Scientific ReportsThe circumsporozoite protein (CSP), an essential protein that covers the surface of the Plasmodium sporozoite, is a key player in multiple stages of the parasite development within the mosquito and during interactions between sporozoites and mammalian ...
Sara J. S. Baptista +7 more
doaj +2 more sources
Plasmodium berghei calcium dependent protein kinase 1 is not required for host cell invasion. [PDF]
PLoS ONE, 2013 Plasmodium Calcium Dependent Protein Kinase (CDPK1) is required for the development of sexual stages in the mosquito. In addition, it is proposed to play an essential role in the parasite's invasive stages possibly through the regulation of the ...
Sylvia Jebiwott +3 more
doaj +2 more sources
Journal of Parasitology Research, 2014 The objective of the present study was to investigate the antiplasmodial effect of the ethanolic stem bark extract of Anthocleista vogelii at different doses in albino mice infected with Plasmodium berghei berghei (NK 65).
Lebari Barine Gboeloh +2 more
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Constitutive expression of Cas9 and rapamycin-inducible Cre recombinase facilitates conditional genome editing in Plasmodium berghei [PDF]
Scientific ReportsMalaria is caused by protozoan parasites of the genus Plasmodium and remains a global health concern. The parasite has a highly adaptable life cycle comprising successive rounds of asexual replication in a vertebrate host and sexual maturation in the ...
Samhita Das +10 more
doaj +2 more sources
Taurine potentiates artemisinin efficacy against malaria by modulating the immune response in Plasmodium berghei-infected mice [PDF]
Parasites & VectorsBackground Artemisinin (ART) is a frontline drug for the treatment of malaria; however, the emergence of ART-resistant Plasmodium strains necessitates increasing ART sensitivity.
Xin Li +8 more
doaj +2 more sources
Evidence-Based Complementary and Alternative Medicine, 2021 Extracts of Alstonia boonei and Carica papaya are used in herbal medicine for the treatment of malaria. This work investigated the phytochemical, antioxidant, and antimalarial effects of hydromethanolic extracts of Alstonia boonei and Carica papaya.
F. O. Atanu +5 more
semanticscholar +1 more source
Journal of Agromedicine and Medical Sciences (AMS), 2021 Malaria is a health problem for the world's population and is predominantly located in tropical and subtropical areas. The three countries with the most malaria cases are India (58%), followed by Indonesia (20%), then Myanmar (16%).
Zainabur Rahmah
doaj +1 more source
Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection. [PDF]
PLoS Pathogens, 2018 Within the liver a single Plasmodium parasite transforms into thousands of blood-infective forms to cause malaria. Here, we use RNA-sequencing to identify host genes that are upregulated upon Plasmodium berghei infection of hepatocytes with the ...
Dora Posfai +9 more
doaj +1 more source