Results 1 to 10 of about 120,310 (212)

Plasmodium berghei K13 Mutations Mediate In Vivo Artemisinin Resistance That Is Reversed by Proteasome Inhibition

mBio, 2020
The recent emergence of Plasmodium falciparum parasite resistance to the first line antimalarial drug artemisinin is of particular concern. Artemisinin resistance is primarily driven by mutations in the P.
Nelson V. Simwela, Barbara H. Stokes, Dana Aghabi, Matt Bogyo, David A. Fidock, Andrew P. Waters   +5 more
doaj   +2 more sources

Transcriptome analysis reveals a de novo DNA element that may interact with chromatin-associated proteins in Plasmodium berghei during erythrocytic development [PDF]

Scientific Reports
The life cycle of Plasmodium parasites involves intricate, multistage processes that are tightly regulated by stage-specific transcription factors. These factors bind to regulatory regions within gene promoters, enabling the precise expression of genes ...
Adaobi Okafor, Yagoub Adam, Benedikt Brors, Ezekiel Adebiyi   +3 more
doaj   +2 more sources

CSP ubiquitylation favours Plasmodium berghei survival during early liver stage infection [PDF]

Scientific Reports
The circumsporozoite protein (CSP), an essential protein that covers the surface of the Plasmodium sporozoite, is a key player in multiple stages of the parasite development within the mosquito and during interactions between sporozoites and mammalian ...
Sara J. S. Baptista, Aparajita Lahree, Sofia Marques, Inês Bento, João Mello-Vieira, António M. Mendes, Vanessa Zuzarte-Luís, Maria M. Mota   +7 more
doaj   +2 more sources

Plasmodium berghei calcium dependent protein kinase 1 is not required for host cell invasion. [PDF]

PLoS ONE, 2013
Plasmodium Calcium Dependent Protein Kinase (CDPK1) is required for the development of sexual stages in the mosquito. In addition, it is proposed to play an essential role in the parasite's invasive stages possibly through the regulation of the ...
Sylvia Jebiwott, Kavitha Govindaswamy, Amos Mbugua, Purnima Bhanot   +3 more
doaj   +2 more sources

Antiplasmodial Effect of Anthocleista vogelii on Albino Mice Experimentally Infected with Plasmodium berghei berghei (NK 65)

Journal of Parasitology Research, 2014
The objective of the present study was to investigate the antiplasmodial effect of the ethanolic stem bark extract of Anthocleista vogelii at different doses in albino mice infected with Plasmodium berghei berghei (NK 65).
Lebari Barine Gboeloh, Okpok Eta Okon, Samuel Effiong Udoh   +2 more
doaj   +2 more sources

Constitutive expression of Cas9 and rapamycin-inducible Cre recombinase facilitates conditional genome editing in Plasmodium berghei [PDF]

Scientific Reports
Malaria is caused by protozoan parasites of the genus Plasmodium and remains a global health concern. The parasite has a highly adaptable life cycle comprising successive rounds of asexual replication in a vertebrate host and sexual maturation in the ...
Samhita Das, Tanaya Unhale, Carine Marinach, Belsy del Carmen Valeriano Alegria, Camille Roux, Hélène Madry, Badreddine Mohand Oumoussa, Rogerio Amino, Shiroh Iwanaga, Sylvie Briquet, Olivier Silvie   +10 more
doaj   +2 more sources

Taurine potentiates artemisinin efficacy against malaria by modulating the immune response in Plasmodium berghei-infected mice [PDF]

Parasites & Vectors
Background Artemisinin (ART) is a frontline drug for the treatment of malaria; however, the emergence of ART-resistant Plasmodium strains necessitates increasing ART sensitivity.
Xin Li, Ning Jiang, Qilong Li, Kexin Zheng, Yiwei Zhang, Xiaoyu Sang, Ying Feng, Ran Chen, Qijun Chen   +8 more
doaj   +2 more sources

Transcriptional heterogeneity and tightly regulated changes in gene expression during Plasmodium berghei sporozoite development

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance A better understanding of the molecular mechanisms underlying the development of Plasmodium parasites in Anopheles mosquitoes would facilitate the development of malaria vaccines and of novel strategies to interrupt disease transmission.
Haikel N. Bogale, T. Pascini, Sachie Kanatani, Juliana M. Sá, T. Wellems, P. Sinnis, J. Vega-Rodríguez, D. Serre   +7 more
semanticscholar   +1 more source

Evaluation of Antimalarial Potential of Extracts from Alstonia boonei and Carica papaya in Plasmodium berghei-Infected Mice

Evidence-Based Complementary and Alternative Medicine, 2021
Extracts of Alstonia boonei and Carica papaya are used in herbal medicine for the treatment of malaria. This work investigated the phytochemical, antioxidant, and antimalarial effects of hydromethanolic extracts of Alstonia boonei and Carica papaya.
F. O. Atanu, F. Idih, C. Nwonuma, H. Hetta, Salman F. Alamery, Gaber El-Saber Batiha   +5 more
semanticscholar   +1 more source

The Effect of Azadirachta indica leaves extract on Transforming Growth Factor-β and Tumor Necrosis Factor-α in a Plasmodium berghei infected Mice model

Journal of Agromedicine and Medical Sciences (AMS), 2021
Malaria is a health problem for the world's population and is predominantly located in tropical and subtropical areas. The three countries with the most malaria cases are India (58%), followed by Indonesia (20%), then Myanmar (16%).
Zainabur Rahmah
doaj   +1 more source