Results 101 to 110 of about 28,420 (218)

In Vitro and In Vivo Antimalarial Activity of LZ1, a Peptide Derived from Snake Cathelicidin

Toxins, 2019
Antimalarial drug resistance is an enormous global threat. Recently, antimicrobial peptides (AMPs) are emerging as a new source of antimalarials. In this study, an AMP LZ1 derived from snake cathelicidin was identified with antimalarial activity.
Yaqun Fang, Xiaoqin He, Pengcheng Zhang, Chuanbin Shen, James Mwangi, Cheng Xu, Guoxiang Mo, Ren Lai, Zhiye Zhang   +8 more
doaj   +1 more source

Maternally supplied S-acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite. [PDF]

, 2016
Transmission of the malaria parasite from the mammalian host to the mosquito vector requires the formation of adequately adapted parasite forms and stage-specific organelles.
Avramut, M Cristina, Chevalley-Maurel, Séverine, Dessens, Johannes T, Duarte, Neuza, Franke-Fayard, Blandine, Frischknecht, Friedrich, Janse, Chris J, Kehrer, Jessica, Koster, Abraham J, Mair, Gunnar R, Ramesar, Jai, Santos, Jorge M   +11 more
core   +2 more sources

IL35 modulation altered survival, cytokine environment and histopathological consequences during malaria infection in mice

Malaria Journal, 2019
Background The immune modulating potential of IL-35 in multiple human disorders has been reported. Consequent upon the recognition of inflammatory cytokine activation and its preponderance for mediating pathology during malaria infection, the study aimed
Ramatu Omenesa Bello, Maizaton Atmadini Abdullah, Roslaini Abd Majid, Voon Kin Chin, Mohammed Faruq Abd Rachman Isnadi, Zaid Osama Ibraheem, Mohd Khairi Hussain, Mohammed Garba Magaji, Rusliza Basir   +8 more
doaj   +1 more source

In vitro activity and in vivo efficacy of omadacycline against Plasmodium species

Malaria Journal
Background Doxycycline is currently the only tetracycline-class antibiotic recommended for malaria prophylaxis. Omadacycline, a semisynthetic aminomethylcycline approved for treatment of adults with community-acquired bacterial pneumonia and acute ...
Michael S. Madejczyk, Susan E. Leed, Karl Kudyba, Alison Roth, Monica L. Martin, Patricia Lee, Diane Anastasiou, Jessica V. Pierce, Alisa W. Serio, Diana Caridha   +9 more
doaj   +1 more source

Activation of human NK cells by Plasmodium-infected red blood cells.

, 2012
This chapter describes a protocol to assess activation of human NK cells following in vitro stimulation with malaria-infected red blood cells. Activation is assessed by flow cytometry, staining for cell surface expression of CD69 and accumulation of ...
Horowitz, Amir, Riley, Eleanor M
core   +1 more source

Cell biology and immunology of malaria.

, 2011
Malaria is a vector-borne infectious disease caused by unicellular parasites of the genus Plasmodium. These obligate intracellular parasites have the unique capacity to infect and replicate within erythrocytes, which are terminally differentiated host ...
Hafalla, Julius Clemence, Matuschewski, Kai, Silvie, Olivier   +2 more
core   +1 more source

Neuroprotective and antimalarial effects of Juglans regia leaf extracts in a murine model of cerebral malaria

Frontiers in Veterinary Science
BackgroundMalaria is a major public health problem caused by the apicomplexan Plasmodium parasite. Cerebral malaria (CM) is the most critical outcome of Plasmodium infection.
Afra Alharbi, Shurug Albasyouni, Esam Al-Shaebi, Saleh Al Quraishy, Rewaida Abdel-Gaber   +4 more
doaj   +1 more source

Multi-system dysregulation in placental malaria contributes to adverse perinatal outcomes in mice

Infection and Immunity
Sequestration of Plasmodium parasites in the placental vasculature contributes to increased morbidity and mortality in pregnant compared to non-pregnant patients in malaria-endemic regions.
Phebe Ekregbesi, Brittany Seibert, Maclaine A. Parish, Yevel Flores-Garcia, Patrick S. Creisher, Joseph P. Hoffmann, Jennifer A. Liu, Cory Brayton, Fidel Zavala, Sabra L. Klein   +9 more
doaj   +1 more source

Plasmodium berghei High-Throughput (PbHiT): a CRISPR-Cas9 System to Study Genes at Scale. [PDF]

Bio Protoc
Jonsdottir TK, Paoletta MS, Henriksson J, Bushell ESC.   +3 more
europepmc   +1 more source

Identification of serine/arginine-rich splicing factor 1-interacting proteins in Plasmodium berghei. [PDF]

Malar J
Niikura M, Koyama Y, Fukuda Y, Kato K, Fukutomi T.   +4 more
europepmc   +1 more source