Results 81 to 90 of about 18,594 (231)

Antiplasmodial Activity and Pharmacokinetic Profiling of Cryptolepine and 2,7‐Dibromocryptolepine With a View to Informing the Design of Novel Antimalarial Cryptolepine Analogues

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT The roots of the climbing shrub Cryptolepis sanguinolenta are traditionally used in West Africa for the treatment of malaria. The principal constituent, cryptolepine (1), has been shown to have antimalarial activity but there are concerns regarding its toxicity on account of its DNA‐intercalating property.
Elodie Chenu, James Duffy, Arnold Donkor Forkuo, Stephen Y. Gbedema, Seham Abdelall, Muhammad Wahajuddin, Huw S. Jones, Colin W. Wright   +7 more
wiley   +1 more source

Prospective identification of malaria parasite genes under balancing selection. [PDF]

, 2009
BACKGROUND: Endemic human pathogens are subject to strong immune selection, and interrogation of pathogen genome variation for signatures of balancing selection can identify important target antigens.
Conway, David J, Lynette Isabella Ochola, Amambua-Ngwa, A, Ochola, LI, Tetteh, Kevin KA, Stewart Lindsay B., Kevin Marsh, Thomas Alan W., Lindsay B Stewart, Alfred Amambua-Ngwa, David J Conway, Gareth D Weedall, Tetteh, KK, Kevin K A Tetteh, Weedall, Gareth D, Conway David J., Marsh Kevin, Weedall Gareth D., Marsh, K, Conway, DJ, Ochola Lynette Isabella, Tetteh Kevin K. A., Stewart, LB, Amambua-Ngwa, Alfred, Weedall, GD, Thomas, AW, Ochola, Lynette Isabella, Stewart, Lindsay B, Thomas, Alan W, Alan W Thomas, Amambua-Ngwa Alfred, Marsh, Kevin   +31 more
core   +1 more source

A Narrative Review of Antioxidant, Anti‐Inflammatory, Anti‐Apoptotic, Immunomodulatory, and Anticancer Properties of Rosa damascena Mill.

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Rosa damascena Mill. exhibits a broad spectrum of pharmacological activities mediated by its rich phytochemical profile. The plant enhances antioxidant defenses by increasing endogenous enzymes (CAT, SOD, GSH, GST, GPx, FRAP) and reducing oxidative stress markers (MDA, MPO).
Mahboobeh Ghasemzadeh Rahbardar, Nikta Soltani, Mohammad Hossein Boskabady   +2 more
wiley   +1 more source

Helminths as architects of trained tolerance: implications for human health

Clinical &Translational Immunology, Volume 15, Issue 3, 2026.
Abstract Helminths infect nearly 2 billion people worldwide and are a major cause of chronic morbidity in low‐resource regions. Unlike bacterial and viral pathogens that elicit protective memory, helminths actively remodel host immunity to enable their years‐long persistence and reinfection.
Quinn Moroz, Jorge Lucas Nascimento Souza, Neima Briggs   +2 more
wiley   +1 more source

Treadted Plasmodium berghei infected pregnant mice by – Andrographis paniculata tablet (AS201 – 01) decreasing the TLR -4 expression and apoptosis index of placental tissue [PDF]

Objective: This study aimed to evaluate the effect of Andrographis paniculata tablet (AS201-01) in decreasing expression of Toll-Like Receptor-4 (TLR-4) and apoptosis index of placental tissue of Plasmodium berghei infected pregnant mice.
Budi Prasetyo, Budi, Hilkatul Ilmi, -, Diantri Nari Ratih, -, Lidya Tumewu, -, Yustinasari, -, Aty Widyawaruyanti, -   +5 more
core   +1 more source

New synchronization method for Plasmodium falciparum [PDF]

, 2010
<b>Background</b>: Plasmodium falciparum is usually asynchronous during in vitro culture. Although various synchronization methods are available, they are not able to narrow the range of ages of parasites.
Lisa C Ranford-Cartwright, Mwangi Jonathan M, Sinha Abhinav, Ranford-Cartwright Lisa C, Humphreys Georgina S, Georgina S Humphreys, Abhinav Sinha, Mwangi, J.M., Jonathan M Mwangi, Ranford-Cartwright, L.C., Sinha, A., Humphreys, G.S.   +11 more
core   +1 more source

Cyclical Transmission of Plasmodium berghei in the Laboratory [PDF]

Nature, 1952
CYCLICAL transmission of P. berghei has been successfully carried out under experimental conditions. A batch of laboratory-bred A. quadrimaculatus and A. stephensi fed on February 15 on a hamster infected eight days previously with the Kasapa strain of P. berghei.
M, YOELL, W J, WALL
openaire   +2 more sources

Protists show high resilience and thrive under multiple chemical stressors

mLife, EarlyView.
Jijuan Ding, Fei Liu, Yuanchen Zhao, Zhili He, Yijing Shi, Longfei Shu   +5 more
wiley   +1 more source

Genetic recombination in Plasmodium berghei

Parasitology, 1973
Crosses have been made between two lines of Plasmodium berghei yoelii differing in drug-sensitivity and enzyme-type. The two lines used were line A, which is pyrimethamine-resistant and contains an electrophoretic form of glucose phosphate isomerase termed GPI-1, and line C, which is pyrimethamine-sensitive and contains enzyme-form GPI-2. Equal numbers
D, Walliker, R, Carter, S, Morgan
openaire   +2 more sources

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, Volume 36, Issue 11, 5 February 2026.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source